Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow In Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Yang, L, Katchman, A, Weinberg, RL, Abrams, J, Samad, T, Wan, E, Pitt, GS, and Marx, SO. "The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart." The Journal of Biological Chemistry 290, no. 4 (January 2015): 2166-2174.

PMID
25505241
Full Text

Betzenhauser, MJ, Pitt, GS, and Antzelevitch, C. "Calcium Channel Mutations in Cardiac Arrhythmia Syndromes." Current molecular pharmacology 8, no. 2 (January 2015): 133-142. (Review)

PMID
25981977
Full Text

Yan, H, Pablo, JL, Wang, C, and Pitt, GS. "FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons." eLife 3 (September 30, 2014): e04193-.

PMID
25269146
Full Text

Wang, C, Chung, BC, Yan, H, Wang, H-G, Lee, S-Y, and Pitt, GS. "Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation." Nature communications 5 (September 18, 2014): 4896-.

PMID
25232683
Full Text

Abbott, GW, and Pitt, GS. "Ion channels under the sun." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, no. 5 (May 2014): 1957-1962.

PMID
24786286
Full Text

Hennessey, JA, Boczek, NJ, Jiang, Y-H, Miller, JD, Patrick, W, Pfeiffer, R, Sutphin, BS, Tester, DJ, Barajas-Martinez, H, Ackerman, MJ, Antzelevitch, C, Kanter, R, and Pitt, GS. "A CACNA1C variant associated with reduced voltage-dependent inactivation, increased CaV1.2 channel window current, and arrhythmogenesis." PloS one 9, no. 9 (January 2014): e106982-.

PMID
25184293
Full Text

Hennessey, JA, Marcou, CA, Wang, C, Wei, EQ, Wang, C, Tester, DJ, Torchio, M, Dagradi, F, Crotti, L, Schwartz, PJ, Ackerman, MJ, and Pitt, GS. "FGF12 is a candidate Brugada syndrome locus." Heart Rhythm 10, no. 12 (December 2013): 1886-1894.

PMID
24096171
Full Text

Hennessey, JA, Marcou, CA, Wang, C, Wei, EQ, Wang, C, Crotti, L, Schwartz, P, Ackerman, MJ, and Pitt, GS. "FGF12 is a Novel Brugada Syndrome Locus." November 26, 2013.

Scholars@Duke

Hennessey, JA, Jiang, Y, Miller, JD, Stadt, HA, Patrick, W, Pfeiffer, R, Antzelevitch, C, Kanter, R, and Pitt, GS. "A CACNA1C Mutation that Causes a Subset of Timothy Syndrome Phenotypes Correlates." Heart Rhythm 10, no. 11 (November 2013): 1745-.

PMID
24210388
Full Text

Hennessey, JA, Wei, EQ, and Pitt, GS. "Fibroblast growth factor homologous factors modulate cardiac calcium channels." Circ Res 113, no. 4 (August 2, 2013): 381-388.

PMID
23804213
Full Text

Pages