Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Pablo, Juan Lorenzo, Chaojian Wang, Matthew M. Presby, and Geoffrey S. Pitt. “Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action.” Proc Natl Acad Sci U S A 113, no. 19 (May 10, 2016): E2665–74. https://doi.org/10.1073/pnas.1521194113.

PMID
27044086
Full Text

Wang, Hong-Gang, Wandi Zhu, Ronald J. Kanter, Jonathan R. Silva, Christina Honeywell, Robert M. Gow, and Geoffrey S. Pitt. “A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.” J Mol Cell Cardiol 92 (March 2016): 52–62. https://doi.org/10.1016/j.yjmcc.2016.01.014.

PMID
26801742
Full Text

Pablo, Juan L., and Geoffrey S. Pitt. “Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease.” Neuroscientist 22, no. 1 (February 2016): 19–25. https://doi.org/10.1177/1073858414562217.

PMID
25492945
Full Text

Choi, Jong-Il, Chaojian Wang, Matthew J. Thomas, and Geoffrey S. Pitt. “α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current.” Plos One 11, no. 3 (2016): e0152355. https://doi.org/10.1371/journal.pone.0152355.

PMID
27028743
Full Text

Zhang, Hengtao, Albert Y. Sun, Jong J. Kim, Victoria Graham, Elizabeth A. Finch, Igor Nepliouev, Guiling Zhao, et al. “STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.” In Proc Natl Acad Sci U S A, 112:E5618–27, 2015. https://doi.org/10.1073/pnas.1503847112.

PMID
26424448
Full Text

Musa, Hassan, Crystal F. Kline, Amy C. Sturm, Nathaniel Murphy, Sara Adelman, Chaojian Wang, Haidun Yan, et al. “SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.” Proc Natl Acad Sci U S A 112, no. 40 (October 6, 2015): 12528–33. https://doi.org/10.1073/pnas.1516430112.

PMID
26392562
Full Text

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