Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Wang, C, Chung, BC, Yan, H, Lee, S-Y, and Pitt, GS. "Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin." Structure 20, no. 7 (July 3, 2012): 1167-1176.

PMID
22705208
Full Text

Amenta, J, and Pitt, GS. "Novel Roles of Fibroblast Growth Factor Homologous Factors in Heart." BIOPHYSICAL JOURNAL 102, no. 3 (January 31, 2012): 34A-34A.

Full Text

Zhong, L, Bellemer, A, Yan, H, Ken, H, Jessica, R, Hwang, RY, Pitt, GS, and Tracey, WD. "Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel." Cell Rep 1, no. 1 (January 26, 2012): 43-55.

PMID
22347718
Full Text

Lodder, EM, Scicluna, BP, Milano, A, Sun, AY, Tang, H, Remme, CA, Moerland, PD, Tanck, MWT, Pitt, GS, Marchuk, DA, and Bezzina, CR. "Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction." PLoS Genet 8, no. 12 (2012): e1003113-.

PMID
23236294
Full Text

Wei, EQ, Barnett, AS, Pitt, GS, and Hennessey, JA. "Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias." Trends Cardiovasc Med 21, no. 7 (October 2011): 199-203. (Review)

PMID
22867699
Full Text

Wang, C, Hennessey, JA, Kirkton, RD, Wang, C, Graham, V, Puranam, RS, Rosenberg, PB, Bursac, N, and Pitt, GS. "Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts." Circ Res 109, no. 7 (September 16, 2011): 775-782.

PMID
21817159
Full Text

Wang, C, Wang, C, Hoch, EG, and Pitt, GS. "Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels." J Biol Chem 286, no. 27 (July 8, 2011): 24253-24263.

PMID
21566136
Full Text

Sun, AY, Koontz, JI, Shah, SH, Piccini, JP, Nilsson, KR, Craig, D, Haynes, C, Gregory, SG, Hranitzky, PM, and Pitt, GS. "The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction." Circ Cardiovasc Genet 4, no. 2 (April 2011): 163-168.

PMID
21498565
Full Text

Sun, AY, and Pitt, GS. "Pinning down the CaMKII targets in the L-type Ca(2+) channel: an essential step in defining CaMKII regulation." Heart Rhythm 8, no. 4 (April 2011): 631-633.

PMID
20933100
Full Text

Wang, H-G, Wang, C, and Pitt, GS. "Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents." PLoS One 6, no. 9 (2011): e25741-.

PMID
21980534
Full Text

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