Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Hennessey, J. A., Y. Jiang, J. D. Miller, H. A. Stadt, W. Patrick, R. Pfeiffer, C. Antzelevitch, R. Kanter, and G. S. Pitt. “A CACNA1C Mutation that Causes a Subset of Timothy Syndrome Phenotypes Correlates.” Heart Rhythm 10, no. 11 (November 2013): 1745. https://doi.org/10.1016/j.hrthm.2013.09.026.

PMID
24210388
Full Text

Wang, Hong-Gang, Xiao Ping He, Qiang Li, Roger D. Madison, Scott D. Moore, James O. McNamara, and Geoffrey S. Pitt. “The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.” J Biol Chem 288, no. 19 (May 10, 2013): 13258–68. https://doi.org/10.1074/jbc.M112.434548.

PMID
23536187
Full Text

Ramachandran, Kapil V., Jessica A. Hennessey, Adam S. Barnett, Xinhe Yin, Harriett A. Stadt, Erika Foster, Raj A. Shah, et al. “Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.” J Clin Invest 123, no. 4 (April 2013): 1638–46. https://doi.org/10.1172/JCI66903.

PMID
23549079
Full Text

Chen, Benny J., Yiqun Jiao, Ping Zhang, Albert Y. Sun, Geoffrey S. Pitt, Divino Deoliveira, Nicholas Drago, Tong Ye, Chen Liu, and Nelson J. Chao. “Long-term in vivo imaging of multiple organs at the single cell level.” Plos One 8, no. 1 (2013): e52087. https://doi.org/10.1371/journal.pone.0052087.

PMID
23300962
Full Text

Daubert, James P., and Geoffrey S. Pitt. “Can polymorphisms predict response to antiarrhythmic drugs in atrial fibrillation?” J Am Coll Cardiol 60, no. 6 (August 7, 2012): 546–47. https://doi.org/10.1016/j.jacc.2012.02.060.

PMID
22726628
Full Text

Stephens, Samuel B., Jonathan C. Schisler, Hans E. Hohmeier, Jie An, Albert Y. Sun, Geoffrey S. Pitt, and Christopher B. Newgard. “A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.” Cell Metab 16, no. 1 (July 3, 2012): 33–43. https://doi.org/10.1016/j.cmet.2012.05.011.

PMID
22768837
Full Text

Wang, Chaojian, Ben C. Chung, Haidun Yan, Seok-Yong Lee, and Geoffrey S. Pitt. “Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin.” Structure 20, no. 7 (July 3, 2012): 1167–76. https://doi.org/10.1016/j.str.2012.05.001.

PMID
22705208
Full Text

Pages