Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow In Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Pitt, GS. "Channeling a New Focus for Heart Failure: Insights Into Ion Channels." JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 54, no. 2 (August 2009): 95-97.

PMID
19597367
Scholars@Duke

Thomsen, MB, Wang, C, Ozgen, N, Wang, H-G, Rosen, MR, and Pitt, GS. "Accessory subunit KChIP2 modulates the cardiac L-type calcium current." Circ Res 104, no. 12 (June 19, 2009): 1382-1389.

PMID
19461043
Full Text

Shah, SH, and Pitt, GS. "Genetics of cardiac repolarization." Nat Genet 41, no. 4 (April 2009): 388-389.

PMID
19338079
Scholars@Duke

Miloushev, VZ, Levine, JA, Arbing, MA, Hunt, JF, Pitt, GS, and Palmer, AG. "Solution structure of the NaV1.2 C-terminal EF-hand domain." J Biol Chem 284, no. 10 (March 6, 2009): 6446-6454.

PMID
19129176
Full Text

Pitt, GS. "Editorial: Channeling a new focus for heart failure: Insights into ion channels." Journal of Cardiovascular Pharmacology 54, no. 2 (2009): 95-97.

Full Text

Pitt, GS. "Calcineurin finds a new partner in the L-type Ca2+ channel." Circulation Research 105, no. 1 (2009): 7-8.

PMID
19571266
Full Text

Wang, C, Wang, H-G, Xie, H, and Pitt, GS. "Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini." J Neurosci 28, no. 8 (February 20, 2008): 1865-1870.

PMID
18287503
Full Text

Wang, H-G, George, MS, Kim, J, Wang, C, and Pitt, GS. "Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons." J Neurosci 27, no. 34 (August 22, 2007): 9086-9093.

PMID
17715345
Full Text

Pitt, B, and Pitt, GS. "Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death." Circulation 115, no. 23 (June 12, 2007): 2976-2982. (Review)

PMID
17562968
Full Text

Pitt, GS. "Calmodulin and CaMKII as molecular switches for cardiac ion channels." Cardiovasc Res 73, no. 4 (March 1, 2007): 641-647. (Review)

PMID
17137569
Full Text

Pages