Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Pitt, B, and Pitt, GS. "Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death." Circulation 115, no. 23 (June 12, 2007): 2976-2982. (Review)

PMID
17562968
Full Text

Pitt, GS. "Calmodulin and CaMKII as molecular switches for cardiac ion channels." Cardiovasc Res 73, no. 4 (March 1, 2007): 641-647. (Review)

PMID
17137569
Full Text

Pitt, B, and Pitt, GS. "Response to Kloner and Cannom." Circulation 115, no. 23 (2007): 2989--.

Full Text

Seu, L, and Pitt, GS. "Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases." J Gen Physiol 128, no. 5 (November 2006): 605-613.

PMID
17074979
Full Text

Pitt, GS, Dun, W, and Boyden, PA. "Remodeled cardiac calcium channels." J Mol Cell Cardiol 41, no. 3 (September 2006): 373-388. (Review)

PMID
16901502
Full Text

Pitt, GS, and Pitt, B. "Aldosterone, ion channels, and sudden death: another piece of the circle?." Am J Physiol Heart Circ Physiol 290, no. 6 (June 2006): H2176-H2177.

PMID
16517947
Full Text

George, MS, and Pitt, GS. "The real estate of cardiac signaling: location, location, location." Proc Natl Acad Sci U S A 103, no. 20 (May 16, 2006): 7535-7536.

PMID
16682624
Full Text

Ghosh, S, Nunziato, DA, and Pitt, GS. "KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin." Circ Res 98, no. 8 (April 28, 2006): 1048-1054.

PMID
16556866
Full Text

Hudmon, A, Schulman, H, Kim, J, Maltez, JM, Tsien, RW, and Pitt, GS. "CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation." J Cell Biol 171, no. 3 (November 7, 2005): 537-547.

PMID
16275756
Full Text

Maltez, JM, Nunziato, DA, Kim, J, and Pitt, GS. "Essential Ca(V)beta modulatory properties are AID-independent." Nat Struct Mol Biol 12, no. 4 (April 2005): 372-377.

PMID
15750602
Full Text

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