Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 515 E. 79th Street, Pha, New York, NY 10075
Phone (919) 257-1589
Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

  • Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
  • Medical Resident, Medicine, Stanford University, 1993 - 1995
  • M.D., Johns Hopkins University, 1993

Publications

Koontz, Jason I., Daniel Haithcock, Valerie Cumbea, Anthony Waldron, Kristie Stricker, Amy Hughes, Kent Nilsson, et al. “Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository.” Am Heart J 158, no. 5 (November 2009): 719–25. https://doi.org/10.1016/j.ahj.2009.08.011.

PMID
19853688
Full Text

Thomsen, Morten B., Chaojian Wang, Nazira Ozgen, Hong-Gang Wang, Michael R. Rosen, and Geoffrey S. Pitt. “Accessory subunit KChIP2 modulates the cardiac L-type calcium current.” Circ Res 104, no. 12 (June 19, 2009): 1382–89. https://doi.org/10.1161/CIRCRESAHA.109.196972.

PMID
19461043
Full Text

Miloushev, Vesselin Z., Joshua A. Levine, Mark A. Arbing, John F. Hunt, Geoffrey S. Pitt, and Arthur G. Palmer. “Solution structure of the NaV1.2 C-terminal EF-hand domain.” J Biol Chem 284, no. 10 (March 6, 2009): 6446–54. https://doi.org/10.1074/jbc.M807401200.

PMID
19129176
Full Text

Wang, Chaojian, Hong-Gang Wang, Hui Xie, and Geoffrey S. Pitt. “Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini.” J Neurosci 28, no. 8 (February 20, 2008): 1865–70. https://doi.org/10.1523/JNEUROSCI.5417-07.2008.

PMID
18287503
Full Text

Wang, Hong-Gang, Meena S. George, James Kim, Chaojian Wang, and Geoffrey S. Pitt. “Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons.” J Neurosci 27, no. 34 (August 22, 2007): 9086–93. https://doi.org/10.1523/JNEUROSCI.1720-07.2007.

PMID
17715345
Full Text

Pages