Geoffrey Stuart Pitt, MD

Adjunct Professor in the Department of Medicine

Faculty Network Member of the Duke Institute for Brain Sciences

Campus mail 515 E. 79th Street, Pha, New York, NY 10075

Phone (919) 257-1589

Email address geoffrey.pitt@duke.edu

Our research focuses on how intracellular Ca2+, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca2+ influx through voltage-gated Ca2+ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca2+ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Education and Training

Fellow in Cardiovascular Medicine, Medicine, Stanford University, 1995 - 1999
Medical Resident, Medicine, Stanford University, 1993 - 1995
M.D., Johns Hopkins University, 1993

Grants

Identifying the mechanosensitive domains of the Piezo1 ion channel by application of localized force

Publications

Pitt, Geoffrey S. “Calmodulin and CaMKII as molecular switches for cardiac ion channels.” Cardiovasc Res 73, no. 4 (March 1, 2007): 641–47. https://doi.org/10.1016/j.cardiores.2006.10.019.

PMID

17137569

Full Text

Seu, Lillian, and Geoffrey S. Pitt. “Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.” J Gen Physiol 128, no. 5 (November 2006): 605–13. https://doi.org/10.1085/jgp.200609631.

PMID

17074979

Full Text

Pitt, Geoffrey S., Wen Dun, and Penelope A. Boyden. “Remodeled cardiac calcium channels.” J Mol Cell Cardiol 41, no. 3 (September 2006): 373–88. https://doi.org/10.1016/j.yjmcc.2006.06.071.

PMID

16901502

Full Text

Pitt, Geoffrey S., and Bertram Pitt. “Aldosterone, ion channels, and sudden death: another piece of the circle?” Am J Physiol Heart Circ Physiol 290, no. 6 (June 2006): H2176–77. https://doi.org/10.1152/ajpheart.00186.2006.

PMID

16517947

Full Text

George, Meena S., and Geoffrey S. Pitt. “The real estate of cardiac signaling: location, location, location.” Proc Natl Acad Sci U S A 103, no. 20 (May 16, 2006): 7535–36. https://doi.org/10.1073/pnas.0602389103.

PMID

16682624

Full Text

Ghosh, Smita, Deborah A. Nunziato, and Geoffrey S. Pitt. “KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin.” Circ Res 98, no. 8 (April 28, 2006): 1048–54. https://doi.org/10.1161/01.RES.0000218863.44140.f2.

PMID

16556866

Full Text

Hudmon, Andy, Howard Schulman, James Kim, Janet M. Maltez, Richard W. Tsien, and Geoffrey S. Pitt. “CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.” J Cell Biol 171, no. 3 (November 7, 2005): 537–47. https://doi.org/10.1083/jcb.200505155.

PMID

16275756

Full Text

Maltez, Janet M., Deborah A. Nunziato, James Kim, and Geoffrey S. Pitt. “Essential Ca(V)beta modulatory properties are AID-independent.” Nat Struct Mol Biol 12, no. 4 (April 2005): 372–77. https://doi.org/10.1038/nsmb909.

PMID

15750602

Full Text

Kim, James, Smita Ghosh, Huajun Liu, Michihiro Tateyama, Robert S. Kass, and Geoffrey S. Pitt. “Calmodulin mediates Ca2+ sensitivity of sodium channels.” J Biol Chem 279, no. 43 (October 22, 2004): 45004–12. https://doi.org/10.1074/jbc.M407286200.

PMID

15316014

Full Text

McGee, Aaron W., Deborah A. Nunziato, Janet M. Maltez, Kenneth E. Prehoda, Geoffrey S. Pitt, and David S. Bredt. “Calcium channel function regulated by the SH3-GK module in beta subunits.” Neuron 42, no. 1 (April 8, 2004): 89–99. https://doi.org/10.1016/s0896-6273(04)00149-7.

PMID

15066267

Full Text

Geoffrey Stuart Pitt, MD

Education and Training

Grants

Publications

Pages