Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Arepally, G, Rebbeck, TR, Song, W, Gilliland, G, Maris, JM, and Poncz, M. "Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML)." Blood 92, no. 7 (October 1, 1998): 2600-2602. (Letter)

PMID
9746808
Scholars@Duke

Arepally, G, and Cines, DB. "Heparin-induced thrombocytopenia and thrombosis." Clin Rev Allergy Immunol 16, no. 3 (1998): 237-247. (Review)

PMID
9773251
Full Text

Blank, M, Cines, DB, Arepally, G, Eldor, A, Afek, A, and Shoenfeld, Y. "Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin." Clin Exp Immunol 108, no. 2 (May 1997): 333-339.

PMID
9158107
Scholars@Duke

Bauer, TL, Arepally, G, Konkle, BA, Mestichelli, B, Shapiro, SS, Cines, DB, Poncz, M, McNulty, S, Amiral, J, Hauck, WW, Edie, RN, and Mannion, JD. "Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery." Circulation 95, no. 5 (March 4, 1997): 1242-1246.

PMID
9054855
Scholars@Duke

Arepally, G, McKenzie, SE, Jiang, XM, Poncz, M, and Cines, DB. "Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis." Blood 89, no. 2 (January 15, 1997): 370-375.

PMID
9002937
Scholars@Duke

Arepally, G, McKenzie, SE, Jiang, X-M, Poncz, M, and Cines, DB. "FcγRIIA H/R131 polymorphism, subclass-specific IgG anti- heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis." Blood 89, no. 2 (1997): 370-375.

Scholars@Duke

Jiang, XM, Arepally, G, Poncz, M, and McKenzie, SE. "Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED)." J Immunol Methods 199, no. 1 (November 29, 1996): 55-59.

PMID
8960098
Scholars@Duke

Arepally, G, Kenyon, LC, and Lavi, E. "Late onset of isolated central nervous system metastasis of liposarcoma--a case report." Am J Clin Oncol 19, no. 4 (August 1996): 351-355.

PMID
8677903
Scholars@Duke

Arepally, G, Reynolds, C, Tomaski, A, Amiral, J, Jawad, A, Poncz, M, and Cines, DB. "Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia." Am J Clin Pathol 104, no. 6 (December 1995): 648-654.

PMID
8526207
Scholars@Duke

Oehler, RL, Sinnott, JT, Arepally, G, and Dunn, YP. "Kaposi's sarcoma mimicking cellulitis." Postgrad Med 94, no. 8 (December 1993): 139-149.

PMID
8247991
Scholars@Duke

Pages