Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Reilly, MP, Taylor, SM, Hartman, NK, Arepally, GM, Cines, DB, Poncz, M, and McKenzie, SE. "Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model demonstrates the requirement for human platelet factor 4 and platelet activation through fcyriia." Blood 96, no. 11 PART I (2000): 221a-.

Scholars@Duke

Arepally, GM. "Characterization of a monoclonal antibody to PF4/heparin (KKO) with functional and serologic properties of hit antibodies." BLOOD 94, no. 10 (November 15, 1999): 21A-21A.

Scholars@Duke

Arepally, GM, Kamei, K, Kisiel, W, Cines, DB, and Poncz, M. "A murine monoclonal PF4/heparin-specific antibody that mimicks heparin-induced thrombocytopenia (HIT) antibodies." THROMBOSIS AND HAEMOSTASIS (August 1999): 530-530.

Scholars@Duke

Blank, M, Eldor, A, Tavor, S, Ziporen, L, Cines, DB, Arepally, G, Afek, A, and Shoenfeld, Y. "A mouse model for heparin-induced thrombocytopenia." Semin Hematol 36, no. 1 Suppl 1 (January 1999): 12-16.

PMID
9930558
Scholars@Duke

Blank, M, Eldor, A, Tavor, S, Ziporen, L, Cines, DB, Arepally, G, Afek, A, and Shoenfeld, Y. "A mouse model for heparin-induced thrombocytopenia." Seminars in Hematology 36, no. SUPPL. 1 (1999): 12-16.

Scholars@Duke

Ziporen, L, Li, ZQ, Park, KS, Sabnekar, P, Liu, WY, Arepally, G, Shoenfeld, Y, Kieber-Emmons, T, Cines, DB, and Poncz, M. "Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia." Blood 92, no. 9 (November 1, 1998): 3250-3259.

PMID
9787161
Scholars@Duke

Arepally, G, Rebbeck, TR, Song, W, Gilliland, G, Maris, JM, and Poncz, M. "Evidence for genetic homogeneity in a familial platelet disorder with predisposition to acute myelogenous leukemia (FPD/AML)." Blood 92, no. 7 (October 1, 1998): 2600-2602. (Letter)

PMID
9746808
Scholars@Duke

Arepally, G, and Cines, DB. "Heparin-induced thrombocytopenia and thrombosis." Clin Rev Allergy Immunol 16, no. 3 (1998): 237-247. (Review)

PMID
9773251
Full Text

Blank, M, Cines, DB, Arepally, G, Eldor, A, Afek, A, and Shoenfeld, Y. "Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin." Clin Exp Immunol 108, no. 2 (May 1997): 333-339.

PMID
9158107
Scholars@Duke

Bauer, TL, Arepally, G, Konkle, BA, Mestichelli, B, Shapiro, SS, Cines, DB, Poncz, M, McNulty, S, Amiral, J, Hauck, WW, Edie, RN, and Mannion, JD. "Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery." Circulation 95, no. 5 (March 1997): 1242-1246.

PMID
9054855
Full Text

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