Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Arepally, Gowthami M., Rui Qi, John Hollingsworth, and Shayela Suvarna. “Determinants of PF4/heparin immunogenicity in a murine model of HIT.” In Blood, 108:32A-33A. AMER SOC HEMATOLOGY, 2006.

Scholars@Duke

Rauova, Lubica, Li Zhai, M Anna Kowalska, Gowthami M. Arepally, Douglas B. Cines, and Mortimer Poncz. “Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications.” Blood 107, no. 6 (March 15, 2006): 2346–53. https://doi.org/10.1182/blood-2005-08-3122.

PMID
16304054
Full Text

Rauova, L., L. Zhai, M. A. Kowalska, G. M. Arepally, D. B. Cines, and M. Poncz. “Pathogenic role of surface platelet factor 4 complexes in heparin-induced thrombocytopenia: Diagnostic and therapeutic implications.” In Blood, 106:21A-21A. AMER SOC HEMATOLOGY, 2005.

Scholars@Duke

Suvarna, Shayela, Lubica Rauova, Emily K. E. McCracken, Christina M. Goss, Bruce S. Sachais, Steven E. McKenzie, Michael P. Reilly, et al. “PF4/heparin complexes are T cell-dependent antigens.” Blood 106, no. 3 (August 1, 2005): 929–31. https://doi.org/10.1182/blood-2004-12-4955.

PMID
15845897
Full Text

Rauova, Lubica, Mortimer Poncz, Steven E. McKenzie, Michael P. Reilly, Gowthami Arepally, John W. Weisel, Chandrasekaran Nagaswami, Douglas B. Cines, and Bruce S. Sachais. “Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.” Blood 105, no. 1 (January 1, 2005): 131–38. https://doi.org/10.1182/blood-2004-04-1544.

PMID
15304392
Full Text

Arepally, G. M., H. M. Homi, F. De Lange, E. K. E. McCracken, T. M. Goss, S. Suvarna, and H. P. Grocott. “Characterization of autoantibodies to PF4/heparin in a rat model of cardiopulmonary bypass.” In Blood, 104:825A-825A. AMER SOC HEMATOLOGY, 2004.

Scholars@Duke

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