Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Gunaratne, R, Frederiksen, J, Thalji, NK, Ho, MD, Arepally, GM, Camire, RM, and Sullenger, BA. "RNA Aptamer Against FXa Synergizes with FXa Catalytic Site Inhibitors to Effectively and Reversibly Anticoagulate Blood in an Ex Vivo Oxygenator Circuit." 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). San Diego, CA. December 3, 2016 - December 6, 2016.: AMER SOC HEMATOLOGY, December 2, 2016.

Scholars@Duke

Onwuemene, O, and Arepally, GM. "Heparin-induced thrombocytopenia: research and clinical updates." Hematology. American Society of Hematology. Education Program 2016, no. 1 (December 2016): 262-268. (Review)

PMID
27913490
Full Text

Cines, DB, Yarovoi, SV, Zaitsev, SV, Lebedeva, T, Rauova, L, Poncz, M, Arepally, GM, Khandelwal, S, Stepanova, V, Rux, AH, Cuker, A, Guo, C, Ocariza, LM, Travers, RJ, Smith, SA, Kim, H, Morrissey, JH, and Conway, EM. "Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia." Blood Advances 1, no. 1 (November 22, 2016): 62-74.

PMID
29296696
Full Text

Arepally, GM. "Should we avoid heparin to eliminate HIT?." Blood Advances 1, no. 1 (November 22, 2016): 4-null.

PMID
29296689
Full Text

Khandelwal, S, Lee, GM, Hester, CG, Poncz, M, McKenzie, SE, Sachais, BS, Rauova, L, Kelsoe, G, Cines, DB, Frank, M, and Arepally, GM. "The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)." Blood 128, no. 14 (October 2016): 1789-1799.

PMID
27412887
Full Text

Khandelwal, S, and Arepally, GM. "Immune pathogenesis of heparin-induced thrombocytopenia." Thrombosis and Haemostasis 116, no. 5 (October 2016): 792-798. (Review)

PMID
27465274
Full Text

Fountain, EM, and Arepally, GM. "THROMBOCYTOPENIA IN HOSPITALIZED NON-ICU PATIENTS." AMERICAN JOURNAL OF HEMATOLOGY 91, no. 9 (September 2016): E401-E401.

Scholars@Duke

Metjian, A, Tanhehco, Y, Pham, HP, Aqui, NA, Bhoj, V, Onwuemene, O, Marques, M, and Arepally, GM. "The Thrombotic Microangiopathy Registry of North America." December 3, 2015.

Scholars@Duke

Fountain, E, and Arepally, GM. "Thrombocytopenia in Hospitalized Non-ICU Patients." December 3, 2015.

Scholars@Duke

Lee, GM, Joglekar, M, Khandelwal, S, Qi, R, Rauova, L, and Arepally, GM. "Characterization of Human and Murine Anti-Protamine/Heparin Antibodies." December 3, 2015.

Scholars@Duke

Pages