Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Onwuemene, Oluwatoyosi A., Steven C. Grambow, Chetan B. Patel, Robert J. Mentz, Carmelo A. Milano, Joseph G. Rogers, Ara D. Metjian, Gowthami M. Arepally, and Thomas L. Ortel. “Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study.” J Clin Apher 33, no. 4 (August 2018): 469–79. https://doi.org/10.1002/jca.21622.

PMID
29524240
Full Text

Gunaratne, Ruwan, Shekhar Kumar, James W. Frederiksen, Steven Stayrook, Jens L. Lohrmann, Kay Perry, Kristin M. Bompiani, et al. “Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.” Nat Biotechnol 36, no. 7 (August 2018): 606–13. https://doi.org/10.1038/nbt.4153.

PMID
29863725
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Khandelwal, Sanjay, Alexandra M. Johnson, Jian Liu, David Keire, Cynthia Sommers, Joann Ravi, Grace M. Lee, John D. Lambris, Edimara S. Reis, and Gowthami M. Arepally. “Novel Immunoassay for Complement Activation by PF4/Heparin Complexes.” Thromb Haemost 118, no. 8 (August 2018): 1484–87. https://doi.org/10.1055/s-0038-1660858.

PMID
29960275
Full Text

Haile, Lydia A., Roshni Rao, Swamy K. Polumuri, Gowthami M. Arepally, David A. Keire, Daniela Verthelyi, and Cynthia D. Sommers. “PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses.” Thromb Res 159 (November 2017): 39–47. https://doi.org/10.1016/j.thromres.2017.09.018.

PMID
28968537
Full Text

Abbes, Sarah, Ara Metjian, Alice Gray, Tereza Martinu, Laurie Snyder, Dong-Feng Chen, Matthew Ellis, Gowthami M. Arepally, and Oluwatoyosi Onwuemene. “Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.” Ther Apher Dial 21, no. 5 (October 2017): 441–50. https://doi.org/10.1111/1744-9987.12570.

PMID
28880430
Full Text

Fountain, Eric M., and Gowthami M. Arepally. “Etiology and complications of thrombocytopenia in hospitalized medical patients.” J Thromb Thrombolysis 43, no. 4 (May 2017): 429–36. https://doi.org/10.1007/s11239-016-1467-8.

PMID
28054307
Full Text

Lee, Grace M., Manali Joglekar, Maragatha Kuchibhatla, Sanjay Khandelwal, Rui Qi, Lubica Rauova, and Gowthami M. Arepally. “Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies.” Blood Adv 1, no. 11 (April 25, 2017): 644–51. https://doi.org/10.1182/bloodadvances.2017004408.

PMID
29296706
Full Text

Hayes, Vincent, Ian Johnston, Gowthami M. Arepally, Steven E. McKenzie, Douglas B. Cines, Lubica Rauova, and Mortimer Poncz. “Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.” J Clin Invest 127, no. 3 (March 1, 2017): 1090–98. https://doi.org/10.1172/JCI90958.

PMID
28218620
Full Text

Pages