Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases.  Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT).  Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.  

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Pishko, Allyson M., Sara Fardin, Daniel S. Lefler, Koosha Paydary, Rolando Vega, Gowthami M. Arepally, Mark Crowther, Lawrence Rice, Douglas B. Cines, and Adam Cuker. “Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia.” Blood Adv 2, no. 22 (November 27, 2018): 3155–62. https://doi.org/10.1182/bloodadvances.2018023077.

PMID
30463915
Full Text

Cuker, Adam, Gowthami M. Arepally, Beng H. Chong, Douglas B. Cines, Andreas Greinacher, Yves Gruel, Lori A. Linkins, et al. “American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.” Blood Adv 2, no. 22 (November 27, 2018): 3360–92. https://doi.org/10.1182/bloodadvances.2018024489.

PMID
30482768
Full Text

Rauova, Lubica, Gowthami Arepally, Mortimer Poncz, and Douglas B. Cines. “Molecular and cellular pathogenesis of heparin-induced thrombocytopenia (HIT).” Autoimmun Rev 17, no. 10 (October 2018): 1046–52. https://doi.org/10.1016/j.autrev.2018.05.003.

PMID
30103043
Full Text

Gollomp, Kandace, Minna Kim, Ian Johnston, Vincent Hayes, John Welsh, Gowthami M. Arepally, Mark Kahn, et al. “Neutrophil accumulation and NET release contribute to thrombosis in HIT.” Jci Insight 3, no. 18 (September 20, 2018). https://doi.org/10.1172/jci.insight.99445.

PMID
30232279
Full Text

Dai, Jing, Daria Madeeva, Vincent Hayes, Hyun Sook Ahn, Valerie Tutwiler, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, and Lubica Rauova. “Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.” Blood 132, no. 7 (August 16, 2018): 727–34. https://doi.org/10.1182/blood-2018-02-830737.

PMID
29914979
Full Text

Onwuemene, Oluwatoyosi A., Steven C. Grambow, Chetan B. Patel, Robert J. Mentz, Carmelo A. Milano, Joseph G. Rogers, Ara D. Metjian, Gowthami M. Arepally, and Thomas L. Ortel. “Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study.” J Clin Apher 33, no. 4 (August 2018): 469–79. https://doi.org/10.1002/jca.21622.

PMID
29524240
Full Text

Gunaratne, Ruwan, Shekhar Kumar, James W. Frederiksen, Steven Stayrook, Jens L. Lohrmann, Kay Perry, Kristin M. Bompiani, et al. “Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.” Nat Biotechnol 36, no. 7 (August 2018): 606–13. https://doi.org/10.1038/nbt.4153.

PMID
29863725
Full Text

Khandelwal, Sanjay, Alexandra M. Johnson, Jian Liu, David Keire, Cynthia Sommers, Joann Ravi, Grace M. Lee, John D. Lambris, Edimara S. Reis, and Gowthami M. Arepally. “Novel Immunoassay for Complement Activation by PF4/Heparin Complexes.” Thromb Haemost 118, no. 8 (August 2018): 1484–87. https://doi.org/10.1055/s-0038-1660858.

PMID
29960275
Full Text

Haile, Lydia A., Roshni Rao, Swamy K. Polumuri, Gowthami M. Arepally, David A. Keire, Daniela Verthelyi, and Cynthia D. Sommers. “PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses.” Thromb Res 159 (November 2017): 39–47. https://doi.org/10.1016/j.thromres.2017.09.018.

PMID
28968537
Full Text

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