Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Herold, CI, Gasparetto, C, and Arepally, GM. "Lenalidomide-Associated ITP." Case Rep Hematol 2011 (2011): 638020-.

PMID
22937309
Full Text

Cuker, A, Arepally, G, Crowther, MA, Rice, L, Datko, F, Hook, K, Propert, KJ, Kuter, DJ, Ortel, TL, Konkle, BA, and Cines, DB. "The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion." Journal of Thrombosis and Haemostasis : Jth 8, no. 12 (December 2010): 2642-2650.

PMID
20854372
Full Text

Chudasama, SL, Espinasse, B, Hwang, F, Qi, R, Joglekar, M, Afonina, G, Wiesner, MR, Welsby, IJ, Ortel, TL, and Arepally, GM. "Heparin modifies the immunogenicity of positively charged proteins." Blood 116, no. 26 (December 2010): 6046-6053.

PMID
20852126
Full Text

Afonina, G, Joglekar, M, Qi, R, and Arepally, GM. "Dendritic Cell Activation by PF4/H Multimolecular Complexes." November 19, 2010.

Scholars@Duke

Joglekar, M, Quintana, P, Marcus, S, Liu, J, and Arepally, GM. "Disruption of PF4/Hep Multimolecular Complex Assembly Using a Minimally Anticoagulant Heparin (ODSH)." November 19, 2010.

Scholars@Duke

Arepally, GM, Chudasama, S, Espinasse, B, Hwang, F, Qi, R, Joglekar, M, Afonina, G, Wiesner, M, Welsby, I, and Ortel, T. "Heparin Modifies the Immunogenicity of Positively-Charged Proteins." November 19, 2010.

Scholars@Duke

Hursting, MJ, Pai, PJ, McCracken, JE, Hwang, F, Suvarna, S, Lokhnygina, Y, Bandarenko, N, and Arepally, GM. "Platelet factor 4/heparin antibodies in blood bank donors." American Journal of Clinical Pathology 134, no. 5 (November 2010): 774-780.

PMID
20959660
Full Text

Crow, S, Chen, D, Milano, C, Thomas, W, Joyce, L, Piacentino, V, Sharma, R, Wu, J, Arepally, G, Bowles, D, Rogers, J, and Villamizar-Ortiz, N. "Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients." The Annals of Thoracic Surgery 90, no. 4 (October 2010): 1263-1269.

PMID
20868825
Full Text

Whitlatch, NL, Kong, DF, Metjian, AD, Arepally, GM, and Ortel, TL. "Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia." Blood 116, no. 10 (September 9, 2010): 1761-1766.

PMID
20508160
Full Text

Crow, S, Milano, C, Joyce, L, Chen, D, Arepally, G, Bowles, D, Thomas, W, and Ortiz, NV. "Comparative analysis of von Willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients." Asaio Journal (American Society for Artificial Internal Organs : 1992) 56, no. 5 (September 2010): 441-445.

PMID
20613494
Full Text

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