Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Hursting, MJ, Pai, PJ, McCracken, JE, Hwang, F, Suvarna, S, Lokhnygina, Y, Bandarenko, N, and Arepally, GM. "Platelet factor 4/heparin antibodies in blood bank donors." Am J Clin Pathol 134, no. 5 (November 2010): 774-780.

PMID
20959660
Full Text

Whitlatch, NL, Kong, DF, Metjian, AD, Arepally, GM, and Ortel, TL. "Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia." Blood 116, no. 10 (September 9, 2010): 1761-1766.

PMID
20508160
Full Text

Homi, HM, Sheng, H, Arepally, GM, Mackensen, GB, and Grocott, HP. "Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass." Anesth Analg 111, no. 1 (July 2010): 38-45.

PMID
20519424
Full Text

Arepally, G, Bauer, KA, Bhatt, DL, Merli, GJ, Naccarelli, GV, Carter, RD, Karcher, RB, Berry, CA, Keaton, KL, and Stowell, SA. "The use of antithrombotic therapies in the prevention and treatment of arterial and venous thrombosis: a survey of current knowledge and practice supporting the need for clinical education." Crit Pathw Cardiol 9, no. 1 (March 2010): 41-48.

PMID
20215910
Full Text

Welsby, IJ, Um, J, Milano, CA, Ortel, TL, and Arepally, G. "Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia." Anesth Analg 110, no. 1 (January 1, 2010): 30-35.

PMID
19933539
Full Text

Crow, S, Chen, D, Milano, C, Thomas, W, Joyce, L, III, VP, Sharma, R, Wu, J, Arepally, G, Bowles, D, Rogers, J, and Villamizar-Ortiz, N. "Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients." Annals of Thoracic Surgery 90, no. 4 (2010): 1263-1269.

PMID
20868825
Full Text

Crow, S, Milano, C, Joyce, L, Chen, D, Arepally, G, Bowles, D, Thomas, W, and Ortiz, NV. "Comparative analysis of von willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients." ASAIO Journal 56, no. 5 (2010): 441-445.

PMID
20613494
Full Text

Arepally, GM, and Ortel, TL. "Heparin-induced thrombocytopenia." Annu Rev Med 61 (2010): 77-90. (Review)

PMID
20059332
Full Text

Glover, S, Key, NS, Arepally, GM, Mackman, N, and Kasthuri, RS. "Characterization of Receptors Involved in Heparin Antibody Complex Mediated Induction of Tissue Factor Expression in Monocytes." November 20, 2009.

Scholars@Duke

Chudasama, S, Espinasse, B, Wiesner, MR, and Arepally, GM. "Heparin Forms Macromolecular Complexes with Protamine and Lysozyme." November 20, 2009.

Scholars@Duke

Pages