Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Arepally, GM, and Hursting, MJ. "Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results." J Thromb Thrombolysis 26, no. 1 (August 2008): 55-61. (Review)

PMID
18369708
Full Text

Suvarna, S, Qi, R, Hollingsworth, JW, and Arepally, GM. "Platelet factor 4-heparin complexes trigger immune responses independently of the MyD88 pathway." Br J Haematol 142, no. 4 (August 2008): 671-673. (Letter)

PMID
18510678
Full Text

Whitlatch, NL, Martin, MG, Shah, BD, and Arepally, GM. "Response to Boctor and Smith." American Journal of Hematology 83, no. 3 (2008): 256--.

Full Text

Suvarna, S, Espinasse, B, Qi, R, Lubica, R, Poncz, M, Cines, DB, Wiesner, MR, and Arepally, GM. "Determinants of PF4/heparin immunogenicity." Blood 110, no. 13 (December 15, 2007): 4253-4260.

PMID
17848616
Full Text

Krakow, EF, Goudar, R, Petzold, E, Suvarna, S, Last, M, Welsby, IJ, Ortel, TL, and Arepally, GM. "Influence of sample collection and storage on the detection of platelet factor 4-heparin antibodies." Am J Clin Pathol 128, no. 1 (July 2007): 150-155.

PMID
17580283
Full Text

Martin, MG, Whitlatch, NL, Shah, B, and Arepally, GM. "Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness." Am J Hematol 82, no. 7 (July 2007): 679-681.

PMID
17266059
Full Text

Hoffman, M, Colina, CM, McDonald, AG, Arepally, GM, Pedersen, L, and Monroe, DM. "Tissue factor around dermal vessels has bound factor VII in the absence of injury." J Thromb Haemost 5, no. 7 (July 2007): 1403-1408.

PMID
17425666
Full Text

Welsby, IJ, Jones, WL, Arepally, G, De Lange, F, Yoshitani, K, Phillips-Bute, B, Grocott, HP, Becker, R, and Mackensen, GB. "Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat." Anesthesiology 106, no. 2 (February 2007): 295-301.

PMID
17264724
Scholars@Duke

Cines, DB, Rauova, L, Arepally, G, Reilly, MP, McKenzie, SE, Sachais, BS, and Poncz, M. "Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly." J Clin Apher 22, no. 1 (February 2007): 31-36. (Review)

PMID
17285619
Full Text

Oney, S, Nimjee, SM, Layzer, J, Que-Gewirth, N, Ginsburg, D, Becker, RC, Arepally, G, and Sullenger, BA. "Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers." Oligonucleotides 17, no. 3 (2007): 265-274.

PMID
17854267
Full Text

Pages