Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases.  Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT).  Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.  

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Kelton, J. G., T. E. Warkentin, J. C. Moore, D. M. Arnold, I. Nazi, G. M. Arepally, J. M. Roach, and I. Fier. “A prospective study measuring the development of antibodies against platelet factor 4-heparin in healthy males after exposure to heparins.” J Thromb Haemost 10, no. 7 (July 2012): 1446–49. https://doi.org/10.1111/j.1538-7836.2012.04759.x.

PMID
22537227
Full Text

Kasthuri, Raj S., Sam L. Glover, William Jonas, Troy McEachron, Rafal Pawlinski, Gowthami M. Arepally, Nigel S. Key, and Nigel Mackman. “PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI.” Blood 119, no. 22 (May 31, 2012): 5285–93. https://doi.org/10.1182/blood-2011-06-359430.

PMID
22394597
Full Text

Joglekar, M. V., P. M. Quintana Diez, S. Marcus, R. Qi, B. Espinasse, M. R. Wiesner, E. Pempe, J. Liu, D. M. Monroe, and G. M. Arepally. “Disruption of PF4/H multimolecular complex formation with a minimally anticoagulant heparin (ODSH).” Thromb Haemost 107, no. 4 (April 2012): 717–25. https://doi.org/10.1160/TH11-11-0795.

PMID
22318669
Full Text

Lee, Grace, and Gowthami M. Arepally. “Anticoagulation techniques in apheresis: from heparin to citrate and beyond.” J Clin Apher 27, no. 3 (2012): 117–25. https://doi.org/10.1002/jca.21222.

PMID
22532037
Full Text

Andrzejewski, Chester, Walter Linz, Jan Hofmann, Una O’Doherty, Richard S. Robinson, Gowthami M. Arepally, and Patricia Golden. “American Society for Apheresis white paper: considerations for medical staff apheresis medicine physician credentialing and privileging.” J Clin Apher 27, no. 6 (2012): 330–35. https://doi.org/10.1002/jca.21250.

PMID
23124963
Full Text

Ortel, Thomas L., Ian Welsby, David F. Kong, John A. Heit, Elizabeth Krakow, Nicole Whitlatch, Gowthami M. Arepally, Grace Lee, Shahar Bar-Yosef, and Eliot C. Williams. “HIT Antibody Seropositivity and Thromboembolic Events After Cardiac Surgery.” In Blood, 118:524–25. AMER SOC HEMATOLOGY, 2011.

Scholars@Duke

Kasthuri, R. S., S. L. Glover, J. William, R. Pawlinski, G. M. Arepally, N. S. Key, and N. Mackman. “Induction of tissue factor expression in monocytes by the platelet factor 4/heparin/antibody complex is mediated by MEK1 and pERK1/2.” Journal of Thrombosis and Haemostasis 9 (July 1, 2011): 265–66.

Scholars@Duke

Chudasama, Shalini L., Benjamin Espinasse, Fred Hwang, Rui Qi, Manali Joglekar, Galyna Afonina, Mark R. Wiesner, Ian J. Welsby, Thomas L. Ortel, and Gowthami M. Arepally. “Heparin modifies the immunogenicity of positively charged proteins.” Blood 116, no. 26 (December 23, 2010): 6046–53. https://doi.org/10.1182/blood-2010-06-292938.

PMID
20852126
Full Text

Cuker, A., G. Arepally, M. A. Crowther, L. Rice, F. Datko, K. Hook, K. J. Propert, et al. “The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion.” J Thromb Haemost 8, no. 12 (December 2010): 2642–50. https://doi.org/10.1111/j.1538-7836.2010.04059.x.

PMID
20854372
Full Text

Pages