Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Rauova, L, Arepally, G, Kenzie, SEM, Konkle, BA, Cines, DB, and Poncz, M. "Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT)." Journal of Thrombosis and Haemostasis 7, no. SUPPL. 1 (2009): 249-252.

PMID
19630810
Full Text

Ragni, MV, Ojeifo, O, Feng, J, Yan, J, Hill, KA, Sommer, SS, Trucco, MN, Brambilla, DJ, Brettler, D, Forand, P, Geary, P, Ewenstein, B, Sweeney, C, Aledort, L, Seremetis, S, McCarthy, J, DiMichelel, D, Goldberg, I, Barron, L, Hams, A, White, G, Nielsen, B, Grimsley, A, Cox-Gill, J, Boyd, A, Green, D, Boggio, L, Harris, S, Hoots, K, Cantini, M, Buchanan, G, Rutherford, C, Dunnagan, P, Haire, W, Hanlon, E, Kisler, T, Sally, S, Giambartolomei, S, Arepally, G, Shhwartz, M, Addiego, J, and Matsunaga, A et al. "Risk factors for inhibitor formation in haemophilia: A prevalent case-control study." Haemophilia 15, no. 5 (2009): 1074-1082.

PMID
19563499
Full Text

Diaz, GC, Prowda, J, Lo, IJ, Arepally, GM, Evans, N, Wheeless, Y, Samstein, B, Guarrera, JV, and Renz, JF. "Transplantation-mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors." Liver Transpl 14, no. 12 (December 2008): 1803-1809. (Review)

PMID
19025920
Full Text

Rauova, L, Arepally, GM, Cines, DB, and Poncz, M. "Monocytes Are a Particularly Favorable Target for Surface Platelet Factor 4 (PF4) Antigenic Complex Formation in Heparin-Induced Thrombocytopenia: New Insights into the Thrombotic Risk in HIT." BLOOD 112, no. 11 (November 16, 2008): 107-107.

Scholars@Duke

Suvarna, S, Qi, R, and Arepally, GM. "Development of mPF4/Heparin Antibodies in a Murine Platelet Activation Model." BLOOD 112, no. 11 (November 16, 2008): 106-107.

Scholars@Duke

Lukes, AS, Reardon, B, and Arepally, G. "Use of the levonorgestrel-releasing intrauterine system in women with hemostatic disorders." Fertil Steril 90, no. 3 (September 2008): 673-677.

PMID
18001734
Full Text

Arepally, GM, and Hursting, MJ. "Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results." J Thromb Thrombolysis 26, no. 1 (August 2008): 55-61. (Review)

PMID
18369708
Full Text

Suvarna, S, Qi, R, Hollingsworth, JW, and Arepally, GM. "Platelet factor 4-heparin complexes trigger immune responses independently of the MyD88 pathway." Br J Haematol 142, no. 4 (August 2008): 671-673. (Letter)

PMID
18510678
Full Text

Whitlatch, NL, Martin, MG, Shah, BD, and Arepally, GM. "Response to Boctor and Smith." American Journal of Hematology 83, no. 3 (2008): 256--.

Full Text

Suvarna, S, Espinasse, B, Qi, R, Lubica, R, Poncz, M, Cines, DB, Wiesner, MR, and Arepally, GM. "Determinants of PF4/heparin immunogenicity." Blood 110, no. 13 (December 2007): 4253-4260.

PMID
17848616
Full Text

Pages