Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Whitlatch, Nicole L., David F. Kong, Ara D. Metjian, Gowthami M. Arepally, and Thomas L. Ortel. “Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia.” Blood 116, no. 10 (September 9, 2010): 1761–66. https://doi.org/10.1182/blood-2010-01-262659.

PMID
20508160
Full Text

Crow, Sheri, Carmelo Milano, Lyle Joyce, Dong Chen, Gowthami Arepally, Dawn Bowles, William Thomas, and Nestor Villamizar Ortiz. “Comparative analysis of von Willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients.” Asaio J 56, no. 5 (September 2010): 441–45. https://doi.org/10.1097/MAT.0b013e3181e5de0a.

PMID
20613494
Full Text

Homi, H Mayumi, Huaxin Sheng, Gowthami M. Arepally, G Burkhard Mackensen, and Hilary P. Grocott. “Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass.” Anesth Analg 111, no. 1 (July 2010): 38–45. https://doi.org/10.1213/ANE.0b013e3181e0549f.

PMID
20519424
Full Text

Arepally, Gowthami, Kenneth A. Bauer, Deepak L. Bhatt, Geno J. Merli, Gerald V. Naccarelli, Reshma D. Carter, Rachel B. Karcher, Carolyn A. Berry, Kimberly L. Keaton, and Stephanie A. Stowell. “The use of antithrombotic therapies in the prevention and treatment of arterial and venous thrombosis: a survey of current knowledge and practice supporting the need for clinical education.” Crit Pathw Cardiol 9, no. 1 (March 2010): 41–48. https://doi.org/10.1097/HPC.0b013e3181d24562.

PMID
20215910
Full Text

Welsby, Ian J., John Um, Carmelo A. Milano, Thomas L. Ortel, and Gowthami Arepally. “Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia.” Anesth Analg 110, no. 1 (January 1, 2010): 30–35. https://doi.org/10.1213/ANE.0b013e3181c3c1cd.

PMID
19933539
Full Text

Glover, Sam, Nigel S. Key, Gowthami M. Arepally, Nigel Mackman, and Raj S. Kasthuri. “Characterization of Receptors Involved in Heparin Antibody Complex Mediated Induction of Tissue Factor Expression in Monocytes.” In Blood, 114:97–98. AMER SOC HEMATOLOGY, 2009.

Scholars@Duke

Chudasama, Shalini, Benjamin Espinasse, Mark R. Wiesner, and Gowthami M. Arepally. “Heparin Forms Macromolecular Complexes with Protamine and Lysozyme.” In Blood, 114:538–39. AMER SOC HEMATOLOGY, 2009.

Scholars@Duke

Smyth, S. S., R. P. McEver, A. S. Weyrich, C. N. Morrell, M. R. Hoffman, G. M. Arepally, P. A. French, H. L. Dauerman, R. C. Becker, and R. C. 2009 Platelet Colloquium Participants. “Platelet functions beyond hemostasis.” J Thromb Haemost 7, no. 11 (November 2009): 1759–66. https://doi.org/10.1111/j.1538-7836.2009.03586.x.

PMID
19691483
Full Text

Ragni, M. V., O. Ojeifo, J. Feng, J. Yan, K. A. Hill, S. S. Sommer, M. N. Trucco, D. J. Brambilla, and D. J. Hemophilia Inhibitor Study. “Risk factors for inhibitor formation in haemophilia: a prevalent case-control study.” Haemophilia 15, no. 5 (September 2009): 1074–82. https://doi.org/10.1111/j.1365-2516.2009.02058.x.

PMID
19563499
Full Text

Pages