Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and complement-mediated diseases.  Dr. Arepally’s long-standing research program investigates the immune pathogenesis of heparin induced thrombocytopenia (HIT).  Current laboratory efforts focus on the role of complement activation in antibody production and thrombosis in HIT, studies of complement inhibitors for immune-complex mediated diseases and diagnostic biomarkers of platelet activation.  

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Afonina, Galyna, Manali Joglekar, Rui Qi, and Gowthami M. Arepally. “Dendritic Cell Activation by PF4/H Multimolecular Complexes.” In Blood, 116:318–19. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Joglekar, Manali, Pedro Quintana, Stephen Marcus, Jian Liu, and Gowthami M. Arepally. “Disruption of PF4/Hep Multimolecular Complex Assembly Using a Minimally Anticoagulant Heparin (ODSH).” In Blood, 116:319–319. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Arepally, Gowthami M., Shalini Chudasama, Benjamin Espinasse, Fred Hwang, Rui Qi, Manali Joglekar, Galyna Afonina, Mark Wiesner, Ian Welsby, and Thomas Ortel. “Heparin Modifies the Immunogenicity of Positively-Charged Proteins.” In Blood, 116:615–16. AMER SOC HEMATOLOGY, 2010.

Scholars@Duke

Hursting, Marcie J., Poulomi J. Pai, Julianna E. McCracken, Fred Hwang, Shayela Suvarna, Yuliya Lokhnygina, Nicholas Bandarenko, and Gowthami M. Arepally. “Platelet factor 4/heparin antibodies in blood bank donors.” Am J Clin Pathol 134, no. 5 (November 2010): 774–80. https://doi.org/10.1309/AJCPG0MNR5NGKNFX.

PMID
20959660
Full Text

Crow, Sheri, Dong Chen, Carmelo Milano, William Thomas, Lyle Joyce, Valentino Piacentino, Riti Sharma, et al. “Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients.” Ann Thorac Surg 90, no. 4 (October 2010): 1263–69. https://doi.org/10.1016/j.athoracsur.2010.04.099.

PMID
20868825
Full Text

Whitlatch, Nicole L., David F. Kong, Ara D. Metjian, Gowthami M. Arepally, and Thomas L. Ortel. “Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia.” Blood 116, no. 10 (September 9, 2010): 1761–66. https://doi.org/10.1182/blood-2010-01-262659.

PMID
20508160
Full Text

Crow, Sheri, Carmelo Milano, Lyle Joyce, Dong Chen, Gowthami Arepally, Dawn Bowles, William Thomas, and Nestor Villamizar Ortiz. “Comparative analysis of von Willebrand factor profiles in pulsatile and continuous left ventricular assist device recipients.” Asaio J 56, no. 5 (September 2010): 441–45. https://doi.org/10.1097/MAT.0b013e3181e5de0a.

PMID
20613494
Full Text

Homi, H Mayumi, Huaxin Sheng, Gowthami M. Arepally, G Burkhard Mackensen, and Hilary P. Grocott. “Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass.” Anesth Analg 111, no. 1 (July 2010): 38–45. https://doi.org/10.1213/ANE.0b013e3181e0549f.

PMID
20519424
Full Text

Arepally, Gowthami, Kenneth A. Bauer, Deepak L. Bhatt, Geno J. Merli, Gerald V. Naccarelli, Reshma D. Carter, Rachel B. Karcher, Carolyn A. Berry, Kimberly L. Keaton, and Stephanie A. Stowell. “The use of antithrombotic therapies in the prevention and treatment of arterial and venous thrombosis: a survey of current knowledge and practice supporting the need for clinical education.” Crit Pathw Cardiol 9, no. 1 (March 2010): 41–48. https://doi.org/10.1097/HPC.0b013e3181d24562.

PMID
20215910
Full Text

Welsby, Ian J., John Um, Carmelo A. Milano, Thomas L. Ortel, and Gowthami Arepally. “Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia.” Anesth Analg 110, no. 1 (January 1, 2010): 30–35. https://doi.org/10.1213/ANE.0b013e3181c3c1cd.

PMID
19933539
Full Text

Pages