Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Krakow, EF, Goudar, R, Petzold, E, Suvarna, S, Last, M, Welsby, IJ, Ortel, TL, and Arepally, GM. "Influence of sample collection and storage on the detection of platelet factor 4-heparin antibodies." American Journal of Clinical Pathology 128, no. 1 (July 2007): 150-155.

PMID
17580283
Full Text

Martin, MG, Whitlatch, NL, Shah, B, and Arepally, GM. "Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness." Am J Hematol 82, no. 7 (July 2007): 679-681.

PMID
17266059
Full Text

Hoffman, M, Colina, CM, McDonald, AG, Arepally, GM, Pedersen, L, and Monroe, DM. "Tissue factor around dermal vessels has bound factor VII in the absence of injury." Journal of Thrombosis and Haemostasis : Jth 5, no. 7 (July 2007): 1403-1408.

PMID
17425666
Full Text

Welsby, IJ, Jones, WL, Arepally, G, De Lange, F, Yoshitani, K, Phillips-Bute, B, Grocott, HP, Becker, R, and Mackensen, GB. "Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat." Anesthesiology 106, no. 2 (February 2007): 295-301.

PMID
17264724
Full Text

Cines, DB, Rauova, L, Arepally, G, Reilly, MP, McKenzie, SE, Sachais, BS, and Poncz, M. "Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly." J Clin Apher 22, no. 1 (February 2007): 31-36. (Review)

PMID
17285619
Full Text

Oney, S, Nimjee, SM, Layzer, J, Que-Gewirth, N, Ginsburg, D, Becker, RC, Arepally, G, and Sullenger, BA. "Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers." Oligonucleotides 17, no. 3 (2007): 265-274.

PMID
17854267
Full Text

Arepally, G, Poncz, M, and Cines, DB. "Autoantibodies in heparin-induced thrombocytopenia." Autoantibodies (2007): 511-519.

Full Text

Arepally, GM, and Ortel, TL. "Heparin-induced thrombocytopenia." NEW ENGLAND JOURNAL OF MEDICINE 355, no. 24 (December 14, 2006): 2598-2599.

Scholars@Duke

Arepally, GM, Qi, R, Hollingsworth, J, and Suvarna, S. "Determinants of PF4/heparin immunogenicity in a murine model of HIT." November 16, 2006.

Scholars@Duke

Arepally, GM, and Ortel, TL. "Clinical practice. Heparin-induced thrombocytopenia." The New England Journal of Medicine 355, no. 8 (August 2006): 809-817. (Review)

PMID
16928996
Full Text

Pages