Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Cines, DB, Rauova, L, Arepally, G, Reilly, MP, McKenzie, SE, Sachais, BS, and Poncz, M. "Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly." J Clin Apher 22, no. 1 (February 2007): 31-36. (Review)

PMID
17285619
Full Text

Welsby, IJ, Jones, WL, Arepally, G, De Lange, F, Yoshitani, K, Phillips-Bute, B, Grocott, HP, Becker, R, and Mackensen, GB. "Effect of combined anticoagulation using heparin and bivalirudin on the hemostatic and inflammatory responses to cardiopulmonary bypass in the rat." Anesthesiology 106, no. 2 (February 2007): 295-301.

PMID
17264724
Scholars@Duke

Oney, S, Nimjee, SM, Layzer, J, Que-Gewirth, N, Ginsburg, D, Becker, RC, Arepally, G, and Sullenger, BA. "Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers." Oligonucleotides 17, no. 3 (2007): 265-274.

PMID
17854267
Full Text

Arepally, G, Poncz, M, and Cines, DB. "Autoantibodies in heparin-induced thrombocytopenia." Autoantibodies (2007): 511-519.

Full Text

Arepally, GM, and Ortel, TL. "Heparin-induced thrombocytopenia." NEW ENGLAND JOURNAL OF MEDICINE 355, no. 24 (December 14, 2006): 2598-2599.

Scholars@Duke

Arepally, GM, Qi, R, Hollingsworth, J, and Suvarna, S. "Determinants of PF4/heparin immunogenicity in a murine model of HIT." November 16, 2006.

Scholars@Duke

Arepally, GM, and Ortel, TL. "Clinical practice. Heparin-induced thrombocytopenia." N Engl J Med 355, no. 8 (August 24, 2006): 809-817. (Review)

PMID
16928996
Full Text

Rauova, L, Zhai, L, Kowalska, MA, Arepally, GM, Cines, DB, and Poncz, M. "Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications." Blood 107, no. 6 (March 15, 2006): 2346-2353.

PMID
16304054
Full Text

Arepally, GM, and Ortel, TL. "The authors reply [21]." New England Journal of Medicine 355, no. 24 (2006): 2598-2599.

Full Text

Arepally, GM, and Warkentin, TE. "Lepirudin: Walking the dosing line." Blood 108, no. 5 (2006): 1428-1429.

Full Text

Pages