Gowthami Morey Arepally, MD

Associate Professor of Medicine
Associate Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is an Associate Professor in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy, studies of therapeutic plasma exchange for HIT and solid organ transplantation. 

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989

Publications

Arepally, G, Poncz, M, and Cines, DB. "Autoantibodies in heparin-induced thrombocytopenia." Autoantibodies (2007): 511-519.

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Arepally, GM, and Ortel, TL. "Heparin-induced thrombocytopenia." NEW ENGLAND JOURNAL OF MEDICINE 355, no. 24 (December 14, 2006): 2598-2599.

Scholars@Duke

Arepally, GM, Qi, R, Hollingsworth, J, and Suvarna, S. "Determinants of PF4/heparin immunogenicity in a murine model of HIT." November 16, 2006.

Scholars@Duke

Arepally, GM, and Ortel, TL. "Clinical practice. Heparin-induced thrombocytopenia." N Engl J Med 355, no. 8 (August 24, 2006): 809-817. (Review)

PMID
16928996
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Rauova, L, Zhai, L, Kowalska, MA, Arepally, GM, Cines, DB, and Poncz, M. "Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications." Blood 107, no. 6 (March 15, 2006): 2346-2353.

PMID
16304054
Full Text

Arepally, GM, and Ortel, TL. "The authors reply [21]." New England Journal of Medicine 355, no. 24 (2006): 2598-2599.

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Arepally, GM, and Warkentin, TE. "Lepirudin: Walking the dosing line." Blood 108, no. 5 (2006): 1428-1429.

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Rauova, L, Zhai, L, Kowalska, MA, Arepally, GM, Cines, DB, and Poncz, M. "Pathogenic role of surface platelet factor 4 complexes in heparin-induced thrombocytopenia: Diagnostic and therapeutic implications." November 16, 2005.

Scholars@Duke

Suvarna, S, Rauova, L, McCracken, EKE, Goss, CM, Sachais, BS, McKenzie, SE, Reilly, MP, Gunn, MD, Cines, DB, Poncz, M, and Arepally, G. "PF4/heparin complexes are T cell-dependent antigens." Blood 106, no. 3 (August 1, 2005): 929-931.

PMID
15845897
Full Text

Rauova, L, Poncz, M, McKenzie, SE, Reilly, MP, Arepally, G, Weisel, JW, Nagaswami, C, Cines, DB, and Sachais, BS. "Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia." Blood 105, no. 1 (January 1, 2005): 131-138.

PMID
15304392
Full Text

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