Gowthami Morey Arepally, MD

Professor of Medicine
Associate Professor of Pathology
Professor of Pathology
Campus mail Duke Box 3486, Durham, NC 27710
Phone (919) 668-3696
Email address arepa001@mc.duke.edu

Gowthami M. Arepally, M.D. is a Professor of Medicine in the Division of Hematology at Duke University Medical Center and the Medical Director of Therapeutic Apheresis at Duke.  Her clinical interests are in immune thrombocytopenias, thrombotic disorders, and applications of therapeutic apheresis for immunologic disorders.    Dr. Arepally’s long-standing research program investigates immunoregulatory mechanisms in HIT.  Current laboratory efforts focus on the role of complement activation in the immune pathogenesis of HIT, investigations of protamine/heparin antibodies and development of murine models for studies of the HIT immune response.  Clinical projects include applications of therapeutic apheresis, including development of a multi-site network for investigations of thrombotic microangiopathy.

Education and Training

  • Fellow in Hematology-Oncology, Medicine, University of Pennsylvania, 1993 - 1997
  • Chief Medical Resident, Medicine, Emory University, 1992 - 1993
  • Medical Resident, Medicine, Emory University, 1989 - 1992
  • M.D., Vanderbilt University, 1989


Ragni, M. V., O. Ojeifo, J. Feng, J. Yan, K. A. Hill, S. S. Sommer, M. N. Trucco, D. J. Brambilla, and D. J. Hemophilia Inhibitor Study. “Risk factors for inhibitor formation in haemophilia: a prevalent case-control study.” Haemophilia 15, no. 5 (September 2009): 1074–82. https://doi.org/10.1111/j.1365-2516.2009.02058.x.

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Rauova, L., G. Arepally, S. E. McKenzie, B. A. Konkle, D. B. Cines, and M. Poncz. “Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).” J Thromb Haemost 7 Suppl 1 (July 2009): 249–52. https://doi.org/10.1111/j.1538-7836.2009.03373.x.

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Pai, Poulomi J., Julianna E. McCracken, and Gowthami M. Arepally. “SEROPREVALENCE OF PF4/HEPARIN ANTIBODIES AMONG BLOOD BANK DONORS.” Pediatric Blood & Cancer 52, no. 6 (June 1, 2009): 710–11.


Diaz, Geraldine C., Joan Prowda, Irene J. Lo, Gowthami M. Arepally, Neal Evans, Yvonne Wheeless, Benjamin Samstein, James V. Guarrera, and John F. Renz. “Transplantation-mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors.” Liver Transpl 14, no. 12 (December 2008): 1803–9. https://doi.org/10.1002/lt.21539.

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Rauova, Lubica, Gowthami M. Arepally, Douglas B. Cines, and Mortimer Poncz. “Monocytes Are a Particularly Favorable Target for Surface Platelet Factor 4 (PF4) Antigenic Complex Formation in Heparin-Induced Thrombocytopenia: New Insights into the Thrombotic Risk in HIT.” Blood 112, no. 11 (November 16, 2008): 107–107.


Suvarna, Shayela, Rui Qi, and Gowtharni M. Arepally. “Development of mPF4/Heparin Antibodies in a Murine Platelet Activation Model.” Blood 112, no. 11 (November 16, 2008): 106–7.


Arepally, Gowthami M., and Marcie J. Hursting. “Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results.” J Thromb Thrombolysis 26, no. 1 (August 2008): 55–61. https://doi.org/10.1007/s11239-008-0217-y.

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