Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center For Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Belsky, DW, Caspi, A, Cohen, HJ, Kraus, WE, Ramrakha, S, Poulton, R, and Moffitt, TE. "Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan." Aging Cell 16, no. 4 (August 2017): 644-651.

PMID
28401731
Full Text

Mandelblatt, JS, Cai, L, Luta, G, Kimmick, G, Clapp, J, Isaacs, C, Pitcher, B, Barry, W, Winer, E, Sugarman, S, Hudis, C, Muss, H, Cohen, HJ, and Hurria, A. "Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance)." Breast cancer research and treatment 164, no. 1 (July 2017): 107-117.

PMID
28364214
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Kimmick, GG, Major, B, Clapp, J, Sloan, J, Pitcher, B, Ballman, K, Barginear, M, Freedman, RA, Artz, A, Klepin, HD, Lafky, JM, Hopkins, J, Winer, E, Hudis, C, Muss, H, Cohen, H, Jatoi, A, Hurria, A, and Mandelblatt, J. "Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503)." Breast cancer research and treatment 163, no. 2 (June 2017): 391-398.

PMID
28283904
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Hall, KS, Cohen, HJ, Pieper, CF, Fillenbaum, GG, Kraus, WE, Huffman, KM, Cornish, MA, Shiloh, A, Flynn, C, Sloane, R, Newby, LK, and Morey, MC. "Physical Performance Across the Adult Life Span: Correlates With Age and Physical Activity." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 72, no. 4 (April 2017): 572-578.

PMID
27356977
Full Text

Roy, CN, Snyder, PJ, Stephens-Shields, AJ, Artz, AS, Bhasin, S, Cohen, HJ, Farrar, JT, Gill, TM, Zeldow, B, Cella, D, Barrett-Connor, E, Cauley, JA, Crandall, JP, Cunningham, GR, Ensrud, KE, Lewis, CE, Matsumoto, AM, Molitch, ME, Pahor, M, Swerdloff, RS, Cifelli, D, Hou, X, Resnick, SM, Walston, JD, Anton, S, Basaria, S, Diem, SJ, Wang, C, Schrier, SL, and Ellenberg, SS. "Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial." Jama Internal Medicine 177, no. 4 (April 2017): 480-490.

PMID
28241237
Full Text

Freedman, RA, Foster, JC, Seisler, DK, Lafky, JM, Muss, HB, Cohen, HJ, Mandelblatt, J, Winer, EP, Hudis, CA, Partridge, AH, Carey, LA, Cirrincione, C, Moreno-Aspitia, A, Kimmick, G, Jatoi, A, and Hurria, A. "Accrual of Older Patients With Breast Cancer to Alliance Systemic Therapy Trials Over Time: Protocol A151527." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 35, no. 4 (February 2017): 421-431.

PMID
27992272
Full Text

Whitson, HE, Duan-Porter, W, Schmader, K, Morey, M, Cohen, HJ, and Colón-Emeric, C. "Response to Letter From De Alfieri et al.: Biological Resilience of Elderly Hospitalized Patients." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 72, no. 1 (January 2017): 142-. (Letter)

PMID
27811154
Full Text

Freedman, RA, Seisler, DK, Foster, JC, Sloan, JA, Lafky, JM, Kimmick, GG, Hurria, A, Cohen, HJ, Winer, EP, Hudis, CA, Partridge, AH, Carey, LA, Jatoi, A, Klepin, HD, Citron, M, Berry, DA, Shulman, LN, Buzdar, AU, Suman, VJ, and Muss, HB. "Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511)." Breast Cancer Research and Treatment 161, no. 2 (January 2017): 363-373.

PMID
27866278
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Hodes, RJ, Sierra, F, Austad, SN, Epel, E, Neigh, GN, Erlandson, KM, Schafer, MJ, LeBrasseur, NK, Wiley, C, Campisi, J, Sehl, ME, Scalia, R, Eguchi, S, Kasinath, BS, Halter, JB, Cohen, HJ, Demark-Wahnefried, W, Ahles, TA, Barzilai, N, Hurria, A, and Hunt, PW. "Disease drivers of aging." Annals of the New York Academy of Sciences 1386, no. 1 (December 2016): 45-68. (Review)

PMID
27943360
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Hurria, A, Akiba, C, Kim, J, Mitani, D, Loscalzo, M, Katheria, V, Koczywas, M, Pal, S, Chung, V, Forman, S, Nathwani, N, Fakih, M, Karanes, C, Lim, D, Popplewell, L, Cohen, H, Canin, B, Cella, D, Ferrell, B, and Goldstein, L. "Reliability, Validity, and Feasibility of a Computer-Based Geriatric Assessment for Older Adults With Cancer." Journal of Oncology Practice 12, no. 12 (December 2016): e1025-e1034.

PMID
27624950
Full Text

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