Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Ha, Christine, Vanessa Cheong, Mary Cooter, Jeffrey N. Browndyke, Eugene Moretti, W. M. Bullock, Brian J. Colin, et al. “Cognitive and Cerebrospinal fluid Alzheimer's Disease biomarker changes over time in older surgical patients and matched nonsurgical controls.” In Anesthesia and Analgesia, 130:502–502, 2020.

Scholars@Duke

Pavon, Juliessa M., Richard J. Sloane, Carl F. Pieper, Cathleen S. Colón-Emeric, David Gallagher, Harvey J. Cohen, Katherine S. Hall, et al. “Physical Activity in the Hospital: Documentation and Influence on Venous Thromboembolism Prophylaxis.” J Aging Phys Act 28, no. 2 (April 24, 2020): 306–10. https://doi.org/10.1123/japa.2018-0462.

PMID
31743088
Full Text

Alliance Cancer in the Older Adult Committee:, Jennifer, Araba Adjei, Jan C. Buckner, Elizabeth Cathcart-Rake, Hongbin Chen, Harvey J. Cohen, Dyda Dao, et al. “Arti Hurria, M.D.: A tribute to her shining legacy in the Alliance for Clinical Trials in Oncology.” J Geriatr Oncol 11, no. 2 (March 2020): 179–83. https://doi.org/10.1016/j.jgo.2019.05.011.

PMID
31201095
Full Text

Wong, Melisa L., Stuart M. Lichtman, Gary R. Morrow, John Simmons, Tomma Hargraves, Cary P. Gross, Jennifer L. Lund, et al. “Geriatric oncology health services research: Cancer and Aging Research Group infrastructure core.” J Geriatr Oncol 11, no. 2 (March 2020): 350–54. https://doi.org/10.1016/j.jgo.2019.07.012.

PMID
31326392
Full Text

DuMontier, Clark, Mina S. Sedrak, Wee Kheng Soo, Cindy Kenis, Grant R. Williams, Kristen Haase, Magnus Harneshaug, et al. “Arti Hurria and the progress in integrating the geriatric assessment into oncology: Young International Society of Geriatric Oncology review paper.” J Geriatr Oncol 11, no. 2 (March 2020): 203–11. https://doi.org/10.1016/j.jgo.2019.08.005.

PMID
31451439
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Shahrokni, Armin, Can-Lan Sun, William P. Tew, Supriya Gupta Mohile, Huiyan Ma, Cynthia Owusu, Heidi D. Klepin, et al. “The association between social support and chemotherapy-related toxicity in older patients with cancer.” J Geriatr Oncol 11, no. 2 (March 2020): 274–79. https://doi.org/10.1016/j.jgo.2019.08.015.

PMID
31501014
Full Text

Sedrak, Mina S., Can-Lan Sun, Allison Magnuson, Hyman Muss, Rachel Freedman, Cary P. Gross, William P. Tew, et al. “Abstract PD10-10: Factors associated with decreased relative dose intensity in older adults with early-stage breast cancer receiving chemotherapy.” In Poster Spotlight Session Abstracts. American Association for Cancer Research, 2020. https://doi.org/10.1158/1538-7445.sabcs19-pd10-10.

Full Text

Noppert, Grace A., A. E. Aiello, A. M. O’Rand, and H. J. Cohen. “Race/Ethnic and Educational Disparities in the Association Between Pathogen Burden and a Laboratory-Based Cumulative Deficits Index.” J Racial Ethn Health Disparities 7, no. 1 (February 2020): 99–108. https://doi.org/10.1007/s40615-019-00638-0.

PMID
31642044
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Klepin, Heidi D., Ellen Ritchie, Brittny Major-Elechi, Jennifer Le-Rademacher, Drew Seisler, Libby Storrick, Ben L. Sanford, et al. “Geriatric assessment among older adults receiving intensive therapy for acute myeloid leukemia: Report of CALGB 361006 (Alliance).” J Geriatr Oncol 11, no. 1 (January 2020): 107–13. https://doi.org/10.1016/j.jgo.2019.10.002.

PMID
31668825
Full Text

Guida, Jennifer L., Tim A. Ahles, Daniel Belsky, Judith Campisi, Harvey Jay Cohen, James DeGregori, Rebecca Fuldner, et al. “Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.” J Natl Cancer Inst 111, no. 12 (December 1, 2019): 1245–54. https://doi.org/10.1093/jnci/djz136.

PMID
31321426
Full Text

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