Geriatrics

Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center For Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Grants

Publications

Mandelblatt, JS, Clapp, JD, Luta, G, Faul, LA, Tallarico, MD, McClendon, TD, Whitley, JA, Cai, L, Ahles, TA, Stern, RA, Jacobsen, PB, Small, BJ, Pitcher, BN, Dura-Fernandis, E, Muss, HB, Hurria, A, Cohen, HJ, and Isaacs, C. "Long-term trajectories of self-reported cognitive function in a cohort of older survivors of breast cancer: CALGB 369901 (Alliance)." Cancer (July 22, 2016).

PMID
27447359
Full Text

Flannery, M, Mohile, SG, Dale, W, Arora, NK, Azar, L, Breslau, ES, Cohen, HJ, Dotan, E, Eldadah, BA, Leach, CR, Mitchell, SA, Rowland, JH, and Hurria, A. "Interventions to improve the quality of life and survivorship of older adults with cancer: The funding landscape at NIH, ACS and PCORI." Journal of geriatric oncology 7, no. 4 (July 2016): 225-233. (Review)

PMID
27197917
Full Text

Hurria, A, Mohile, S, Gajra, A, Klepin, H, Muss, H, Chapman, A, Feng, T, Smith, D, Sun, C-L, De Glas, N, Cohen, HJ, Katheria, V, Doan, C, Zavala, L, Levi, A, Akiba, C, and Tew, WP. "Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 20 (July 2016): 2366-2371.

PMID
27185838
Full Text

Williams, GR, Mackenzie, A, Magnuson, A, Olin, R, Chapman, A, Mohile, S, Allore, H, Somerfield, MR, Targia, V, Extermann, M, Cohen, HJ, Hurria, A, and Holmes, H. "Comorbidity in older adults with cancer." Journal of geriatric oncology 7, no. 4 (July 2016): 249-257. (Review)

PMID
26725537
Full Text

Magnuson, A, Allore, H, Cohen, HJ, Mohile, SG, Williams, GR, Chapman, A, Extermann, M, Olin, RL, Targia, V, Mackenzie, A, Holmes, HM, and Hurria, A. "Geriatric assessment with management in cancer care: Current evidence and potential mechanisms for future research." Journal of geriatric oncology 7, no. 4 (July 2016): 242-248. (Review)

PMID
27197915
Full Text

Stinchcombe, T, Zhang, YJ, Vokes, EE, Schiller, JH, Bradley, JD, Curran, WJ, Movsas, B, Schild, SE, Clamon, GH, Govindan, R, Blumenschein, GR, Socinski, MA, Ready, N, Akerley, WL, Cohen, HJ, Pang, H, and Wang, XF. "A pooled analysis of concurrent chemoradiotherapy (CCRT) for patients with stage III non-small cell lung cancer (NSCLC) who participated in US cooperative group trials: Comparing the outcomes of elderly to younger patients (pts)." May 20, 2016.

Full Text

Freedman, RA, Seisler, DK, Foster, JC, Lafky, JM, Kimmick, GG, Jatoi, A, Muss, HB, Cohen, HJ, Mandelblatt, JS, Winer, EP, Hudis, CA, Cirrincione, CT, Moreno-Aspitia, A, and Hurria, A. "Accrual of older patients (pts) with breast cancer to Alliance systemic therapy trials over time: A151527." May 20, 2016.

Full Text

Hurria, A, Levit, LA, Dale, W, Mohile, SG, Muss, HB, Fehrenbacher, L, Magnuson, A, Lichtman, SM, Bruinooge, SS, Soto-Perez-de-Celis, E, Tew, WP, Postow, MA, and Cohen, HJ. "Reply to N. Lowy et al and to J. Dhanda et al." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 14 (May 2016): 1708-1709.

PMID
27001583
Full Text

Pearce, MJ, Koenig, HG, Robins, CJ, Daher, N, Shaw, SF, Nelson, B, Berk, LS, Belinger, D, Cohen, HJ, and King, MB. "Effects of Religious Versus Conventional Cognitive-Behavioral Therapy on Gratitude in Major Depression and Chronic Medical Illness: A Randomized Clinical Trial." Journal of Spirituality in Mental Health 18, no. 2 (April 2, 2016): 124-144.

Full Text

Jatoi, A, Muss, H, Allred, JB, Cohen, HJ, Ballman, K, Hopkins, JO, Gajra, A, Lafky, J, Wolff, A, Kottschade, L, Gralow, J, and Hurria, A. "Social support and its implications in older, early-stage breast cancer patients in CALGB 49907 (Alliance A171301)." Psycho-oncology 25, no. 4 (April 2016): 441-446.

PMID
25994447
Full Text

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