Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Blair, Cindy K., David R. Jacobs, Wendy Demark-Wahnefried, Harvey J. Cohen, Miriam C. Morey, Kim Robien, and DeAnn Lazovich. “Effects of cancer history on functional age and mortality.” Cancer 125, no. 23 (December 1, 2019): 4303–9. https://doi.org/10.1002/cncr.32449.

PMID
31418826
Full Text

Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.

PMID
31085945
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DeSantis, Carol E., Kimberly D. Miller, William Dale, Supriya G. Mohile, Harvey J. Cohen, Corinne R. Leach, Ann Goding Sauer, Ahmedin Jemal, and Rebecca L. Siegel. “Cancer statistics for adults aged 85 years and older, 2019.” Ca Cancer J Clin 69, no. 6 (November 2019): 452–67. https://doi.org/10.3322/caac.21577.

PMID
31390062
Full Text

Rasmussen, Line Jee Hartmann, Avshalom Caspi, Antony Ambler, Jonathan M. Broadbent, Harvey J. Cohen, Tracy d’Arbeloff, Maxwell Elliott, et al. “Association of Neurocognitive and Physical Function With Gait Speed in Midlife.” Jama Netw Open 2, no. 10 (October 2, 2019): e1913123. https://doi.org/10.1001/jamanetworkopen.2019.13123.

PMID
31603488
Full Text

Ambrosy, Andrew P., Jerry H. Gurwitz, Grace H. Tabada, Andrew Artz, Stanley Schrier, Sunil V. Rao, Huiman X. Barnhart, et al. “Incident anaemia in older adults with heart failure: rate, aetiology, and association with outcomes.” Eur Heart J Qual Care Clin Outcomes 5, no. 4 (October 1, 2019): 361–69. https://doi.org/10.1093/ehjqcco/qcz010.

PMID
30847487
Full Text

Muss, Hyman B., Mei-Yin C. Polley, Donald A. Berry, Heshan Liu, Constance T. Cirrincione, Maria Theodoulou, Ann M. Mauer, et al. “Randomized Trial of Standard Adjuvant Chemotherapy Regimens Versus Capecitabine in Older Women With Early Breast Cancer: 10-Year Update of the CALGB 49907 Trial.” J Clin Oncol 37, no. 26 (September 10, 2019): 2338–48. https://doi.org/10.1200/JCO.19.00647.

PMID
31339827
Full Text

Newman, John C., Julie L. Sokoloski, Paul D. Robbins, Laura J. Niedernhofer, May J. Reed, Jeanne Wei, Steven N. Austad, et al. “Creating the Next Generation of Translational Geroscientists.” J Am Geriatr Soc 67, no. 9 (September 2019): 1934–39. https://doi.org/10.1111/jgs.16055.

PMID
31287934
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Deardorff, William James, Phillip L. Liu, Richard Sloane, Courtney Van Houtven, Carl F. Pieper, Susan Nicole Hastings, Harvey J. Cohen, and Heather E. Whitson. “Association of Sensory and Cognitive Impairment With Healthcare Utilization and Cost in Older Adults.” J Am Geriatr Soc 67, no. 8 (August 2019): 1617–24. https://doi.org/10.1111/jgs.15891.

PMID
30924932
Full Text

Walston, Jeremy, Karen Bandeen-Roche, Brian Buta, Howard Bergman, Thomas M. Gill, John E. Morley, Linda P. Fried, et al. “Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary.” J Am Geriatr Soc 67, no. 8 (August 2019): 1559–64. https://doi.org/10.1111/jgs.15928.

PMID
31045254
Full Text

Ganti, Apar Kishor, Xiaofei Wang, Thomas E. Stinchcombe, Yinpeng Wang, Jeffrey Bradley, Harvey J. Cohen, Karen Kelly, et al. “Clinical prognostic model for older patients with advanced non-small cell lung cancer.” J Geriatr Oncol 10, no. 4 (July 2019): 555–59. https://doi.org/10.1016/j.jgo.2019.02.007.

PMID
30797707
Full Text

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