Geriatrics

Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center For Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Grants

Publications

Hodes, RJ, Sierra, F, Austad, SN, Epel, E, Neigh, GN, Erlandson, KM, Schafer, MJ, LeBrasseur, NK, Wiley, C, Campisi, J, Sehl, ME, Scalia, R, Eguchi, S, Kasinath, BS, Halter, JB, Cohen, HJ, Demark-Wahnefried, W, Ahles, TA, Barzilai, N, Hurria, A, and Hunt, PW. "Disease drivers of aging." Annals of the New York Academy of Sciences 1386, no. 1 (December 2016): 45-68. (Review)

PMID
27943360
Full Text

Hurria, A, Akiba, C, Kim, J, Mitani, D, Loscalzo, M, Katheria, V, Koczywas, M, Pal, S, Chung, V, Forman, S, Nathwani, N, Fakih, M, Karanes, C, Lim, D, Popplewell, L, Cohen, H, Canin, B, Cella, D, Ferrell, B, and Goldstein, L. "Reliability, Validity, and Feasibility of a Computer-Based Geriatric Assessment for Older Adults With Cancer." Journal of Oncology Practice 12, no. 12 (December 2016): e1025-e1034.

PMID
27624950
Full Text

Van Der Walde, N, Jagsi, R, Dotan, E, Baumgartner, J, Browner, IS, Burhenn, P, Cohen, HJ, Edil, BH, Edwards, B, Extermann, M, Ganti, AKP, Gross, C, Hubbard, J, Keating, NL, Korc-Grodzicki, B, McKoy, JM, Medeiros, BC, Mrozek, E, O'Connor, T, Rugo, HS, Rupper, RW, Shepard, D, Silliman, RA, Stirewalt, DL, Tew, WP, Walter, LC, Wildes, T, Bergman, MA, Sundar, H, and Hurria, A. "Older adult oncology, version 2.2016: Featured updates to the NCCN guidelines." Jnccn Journal of the National Comprehensive Cancer Network 14, no. 11 (November 1, 2016): 1357-1370. (Review)

Scholars@Duke

VanderWalde, N, Jagsi, R, Dotan, E, Baumgartner, J, Browner, IS, Burhenn, P, Cohen, HJ, Edil, BH, Edwards, B, Extermann, M, Ganti, AKP, Gross, C, Hubbard, J, Keating, NL, Korc-Grodzicki, B, Mckoy, JM, Medeiros, BC, Mrozek, E, O'Connor, T, Rugo, HS, Rupper, RW, Shepard, D, Silliman, RA, Stirewalt, DL, Tew, WP, Walter, LC, Wildes, T, Bergman, MA, Sundar, H, and Hurria, A. "NCCN Guidelines (R) Insights Older Adult Oncology, Version 2.2016 Featured Updates to the NCCN Guidelines." JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK 14, no. 11 (November 1, 2016): 1357-1370.

Full Text

Kraus, WE, Pieper, CF, Huffman, KM, Thompson, DK, Kraus, VB, Morey, MC, Cohen, HJ, Ravussin, E, Redman, LM, Bain, JR, Stevens, RD, and Newgard, CB. "Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 71, no. 11 (November 2016): 1507-1513.

PMID
26984390
Full Text

Whitson, HE, Duan-Porter, W, Schmader, K, Morey, M, Cohen, HJ, and Colón-Emeric, C. "Response to Ukraintseva et al. Letter: Resilience Versus Robustness in Aging." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 71, no. 11 (November 2016): 1535-1536. (Letter)

PMID
27445404
Full Text

Duan-Porter, W, Cohen, HJ, Demark-Wahnefried, W, Sloane, R, Pendergast, JF, Snyder, DC, and Morey, MC. "Physical resilience of older cancer survivors: An emerging concept." Journal of geriatric oncology 7, no. 6 (November 2016): 471-478.

PMID
27478133
Full Text

Pang, HH, Wang, X, Stinchcombe, TE, Wong, ML, Cheng, P, Ganti, AK, Sargent, DJ, Zhang, Y, Hu, C, Mandrekar, SJ, Redman, MW, Manola, JB, Schilsky, RL, Cohen, HJ, Bradley, JD, Adjei, AA, Gandara, D, Ramalingam, SS, and Vokes, EE. "Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 34, no. 33 (November 2016): 3992-3999.

PMID
27646951
Full Text

VanderWalde, N, Jagsi, R, Dotan, E, Baumgartner, J, Browner, IS, Burhenn, P, Cohen, HJ, Edil, BH, Edwards, B, Extermann, M, Ganti, AKP, Gross, C, Hubbard, J, Keating, NL, Korc-Grodzicki, B, McKoy, JM, Medeiros, BC, Mrozek, E, O'Connor, T, Rugo, HS, Rupper, RW, Shepard, D, Silliman, RA, Stirewalt, DL, Tew, WP, Walter, LC, Wildes, T, Bergman, MA, Sundar, H, and Hurria, A. "NCCN Guidelines Insights: Older Adult Oncology, Version 2.2016." Journal of the National Comprehensive Cancer Network : Jnccn 14, no. 11 (November 2016): 1357-1370.

PMID
27799507
Full Text

Mandelblatt, JS, Clapp, JD, Luta, G, Faul, LA, Tallarico, MD, McClendon, TD, Whitley, JA, Cai, L, Ahles, TA, Stern, RA, Jacobsen, PB, Small, BJ, Pitcher, BN, Dura-Fernandis, E, Muss, HB, Hurria, A, Cohen, HJ, and Isaacs, C. "Long-term trajectories of self-reported cognitive function in a cohort of older survivors of breast cancer: CALGB 369901 (Alliance)." Cancer 122, no. 22 (November 2016): 3555-3563.

PMID
27447359
Full Text

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