Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center For Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Koenig, HG, Meador, KG, Cohen, HJ, and Blazer, DG. "Detection and treatment of major depression in older medically ill hospitalized patients." Int J Psychiatry Med 18, no. 1 (1988): 17-31.

PMID
3397224
Scholars@Duke

Cohen, HJ. "Monoclonal gammopathies and aging." Hospital Practice 23, no. 3 A (1988): 75-80+82+85.

Scholars@Duke

Weston, B, Grufferman, S, MacMillan, JP, and Cohen, HJ. "Effects of socioeconomic and clinical factors on survival in multiple myeloma." J Clin Oncol 5, no. 12 (December 1987): 1977-1984.

PMID
3681379
Full Text

Ryan, DH, Chapple, CW, Kossover, SA, Sandberg, AA, and Cohen, HJ. "Phenotypic similarities and differences between CALLA-positive acute lymphoblastic leukemia cells and normal marrow CALLA-positive B cell precursors." Blood 70, no. 3 (September 1987): 814-821.

PMID
2957002
Scholars@Duke

DeMaria, LC, and Cohen, HJ. "Characteristics of lung cancer in elderly patients." J Gerontol 42, no. 5 (September 1987): 540-545.

PMID
3624814
Scholars@Duke

Steel, K, Applegate, W, Barry, P, Beattie, L, Beck, J, Benson, J, Cohen, H, Fiatarone, M, Hazzard, W, Libow, L, Pawlson, LG, and Walsh, J. "Guidelines For Fellowship Training Programs In Geriatric Medicine." Journal of the American Geriatrics Society 35, no. 8 (August 1987): 792-795.

Full Text

Takahashi, K, Avissar, N, Whitin, J, and Cohen, H. "Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme." Archives of biochemistry and biophysics 256, no. 2 (August 1987): 677-686.

PMID
3619451
Full Text

Crawford, J, and Cohen, HJ. "Relationship of cancer and aging." Clin Geriatr Med 3, no. 3 (August 1987): 419-432. (Review)

PMID
3308041
Scholars@Duke

Tollefsbol, TO, and Cohen, HJ. "The effects of aging on phosphofructokinase induction during lymphocyte mitogenesis in relation to DNA and protein synthesis." Mol Cell Biochem 75, no. 2 (June 1987): 113-122.

PMID
2957585
Scholars@Duke

Becker, PM, Mcvey, LJ, Saltz, CC, Feussner, JR, and Cohen, HJ. "Hospital-Acquired Complications in a Randomized Controlled Clinical Trial of a Geriatric Consultation Team." JAMA: The Journal of the American Medical Association 257, no. 17 (May 1, 1987): 2313-2317.

Full Text

Pages