Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Cohen, HJ, Drew, RT, Johnson, JL, and Rajagopalan, KV. "Molecular basis of the biological function of molybdenum. The relationship between sulfite oxidase and the acute toxicity of bisulfite and SO2." Proceedings of the National Academy of Sciences of the United States of America 70, no. 12 (1973): I-.

Scholars@Duke

Cohen, HJ, Betcher-Lange, S, Kessler, DL, and Rajagopalan, KV. "Hepatic sulfite oxidase. Congruency in mitochondria of prosthetic groups and activity." J Biol Chem 247, no. 23 (December 10, 1972): 7759-7766.

PMID
4344230
Scholars@Duke

Cohen, HJ. "Macular amyloidosis." Arch Dermatol 106, no. 5 (November 1972): 766-767.

PMID
4635810
Scholars@Duke

Cohen, HJ, and Laszlo, J. "Influence of trauma on the unusual distribution of metastases from carcinoma of the larynx." Cancer 29, no. 2 (February 1972): 466-471.

PMID
5013548
Scholars@Duke

Cohen, HJ, Fridovich, I, and Rajagopalan, KV. "Hepatic sulfite oxidase. A functional role for molybdenum." J Biol Chem 246, no. 2 (January 25, 1971): 374-382.

PMID
5100417
Scholars@Duke

Cohen, HJ, Harris, TM, Geller, AM, and Byrne, WL. "Bovine hepatic fructose 1,6-diphosphatase: β-glycerophosphate hydrolysis-evidence for a shared active site." Archives of Biochemistry and Biophysics 146, no. 1 (1971): 144-152.

PMID
4335480
Scholars@Duke

Cohen, HJ. "Low serum iron levels." N Engl J Med 283, no. 21 (November 19, 1970): 1170-.

PMID
5474356
Full Text

Cohen, H, Chapman, AL, Ebert, JW, Bopp, WJ, and Gravelle, CR. "Cellular transmission of canine lymphoma and leukemia in beagles." Journal of the National Cancer Institute 45, no. 5 (1970): 1013-1023.

Scholars@Duke

Swenson, RM, Cohen, HJ, D'Amico, RP, and Kern, M. "The synthesis and secretion of gamma-globulin by lymph node cells. V. The dissociation of the microsome-antibody complex with enzymatically and chemically altered gamma-globulins." J Biol Chem 244, no. 2 (January 25, 1969): 440-448.

PMID
4180044
Scholars@Duke

Cohen, HJ, and Kern, M. "Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions." Biochim Biophys Acta 188, no. 2 (1969): 255-264.

PMID
4186267
Scholars@Duke

Pages