Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Cohen, H. J., and H. R. Silberman. “Long term evaluation of prognostic factors in BCNU, cyclophosphamide, prednisone (BCP) treatment of myeloma.” Proceedings of the American Association for Cancer Research Vol.18 (January 1, 1977).

Scholars@Duke

Osband, M., H. Cohen, J. R. Cassady, and N. Jaffe. “Severe and protracted bone marrow dysfunction following long term therapy with methyl CCNU.” Proceedings of the American Association for Cancer Research Vol.18 (January 1, 1977).

Scholars@Duke

Jarvis, S. C., R. Snyderman, and H. J. Cohen. “Human lymphocyte motility: normal characteristics and anomalous behavior of chronic lymphocytic leukemia cells..” Blood 48, no. 5 (November 1976): 717–29.

PMID
1086108
Scholars@Duke

Cohen, H. J., N. Abramson, A. Bartolucci, and J. Bailar. “BCNU, cyclophosphamide, and prednisone (BCP) vs. melphalan and prednisone (MP) in myeloma.” Proceedings of the American Association for Cancer Research Vol.17 (January 1, 1976).

Scholars@Duke

Cohen, H., C. E. Schmidt, S. R. Lucas, and J. L. Palmer. “Combination chemotherapy with vincristine, cyclophosphamide, and prednisone producing long-term remission of a transplanted canine lymphoma..” Am J Vet Res 36, no. 10 (October 1975): 1483–87.

PMID
1238040
Scholars@Duke

Zevon, S. S., H. J. Cohen, and S. B. Frank. “Dowstream bacterial emboli..” New York State Journal of Medicine 75, no. 9 (August 1975): 1552–53.

PMID
1057081
Scholars@Duke

Cohen, H. J., L. S. Lessin, J. Hallal, and P. Burkholder. “Resolution of primary amyloidosis during chemotherapy. Studies in a patient with nephrotic syndrome..” Ann Intern Med 82, no. 4 (April 1975): 466–73. https://doi.org/10.7326/0003-4819-82-4-466.

PMID
1119764
Full Text

Hauch, T. W., J. D. Shelbourne, H. J. Cohen, D. Mason, and W. B. Kremer. “Meningeal mycosis fungoides: clinical and cellular characteristics..” Ann Intern Med 82, no. 4 (April 1975): 499–505. https://doi.org/10.7326/0003-4819-82-4-499.

PMID
1168035
Full Text

Cohen, H. J. “Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes..” J Clin Invest 55, no. 1 (January 1975): 84–93. https://doi.org/10.1172/JCI107921.

PMID
1088910
Full Text

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