Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Cohen, H. J., and M. E. Chovaniec. “Superoxide generation by digitonin-stimulated guinea pig granulocytes. A basis for a continuous assay for monitoring superoxide production and for the study of the activation of the generating system..” The Journal of Clinical Investigation 61, no. 4 (April 1978): 1081–87. https://doi.org/10.1172/jci109007.

PMID
26695
Full Text

Cohen, H. J., and M. E. Chovaniec. “Superoxide production by digitonin-stimulated guinea pig granulocytes. The effects of N-ethyl maleimide, divalent cations; and glycolytic and mitochondrial inhibitors on the activation of the superoxide generating system..” The Journal of Clinical Investigation 61, no. 4 (April 1978): 1088–96. https://doi.org/10.1172/jci109008.

PMID
207722
Full Text

Cohen, H. J. “B-cell lymphosarcoma cell leukemia: dynamics of surface-membrance immunoglobulin. Value for differentiation from chronic lymphocytic leukemia..” Ann Intern Med 88, no. 3 (March 1978): 317–22.

PMID
343679
Scholars@Duke

Cohen, H. J., A. Gonzalvo, J. Krook, T. T. Thompson, and W. B. Kremer. “New presentation of alpha heavy chain disease: North American polypoid gastrointestinal lymphoma. Clinical and cellular studies..” Cancer 41, no. 3 (March 1978): 1161–69.

PMID
416900
Scholars@Duke

Weinstein, H., T. Griffin, and H. Cohen. “Pharmacology of cytosine arabinoside (a-C).” Proceedings of the American Association for Cancer Research Vol. 19 (January 1, 1978).

Scholars@Duke

Cohen, H. J., M. E. Chovaniec, S. Ellis, and G. Laforet. “Bacterial killing and oxidative metabolism in chlorpromazine (CPZ) treated polymorphonuclear leukocytes (PMN): a model for chronic granulomatous disease (CGD).” Pediatric Research 12, no. 4 II (January 1, 1978).

Scholars@Duke

Pozner, L. H., C. A. Daniels, J. A. Cooper, H. J. Cohen, G. L. Logue, and B. P. Croker. “Replication of type I herpes simplex virus in primary cultures of hairy cell leukemic leukocytes..” Am J Pathol 90, no. 1 (January 1978): 187–200.

PMID
202167
Scholars@Duke

Cohen, H. J., and N. Jaffe. “Pharmacokinetic and clinical studies of 24-h infusions of high-dose methotrexate..” Cancer Chemother Pharmacol 1, no. 1 (1978): 61–64.

PMID
373909
Scholars@Duke

Beardsley, G. P., and H. J. Cohen. “Corticosteroid-induced lymphocytopenia in man: absence of splenic influence and effect of recipient serum..” Am J Hematol 4, no. 3 (1978): 255–59.

PMID
717389
Scholars@Duke

Pages