Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Professor of Medicine, in the School of Medicine
Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 3502 Blue Zone Duke Clinic, Center For Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7502
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.

Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.

Education and Training

  • M.D., State University of New York at Brooklyn, 1965

Publications

Cohen, HJ. "Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes." J Clin Invest 55, no. 1 (January 1975): 84-93.

PMID
1088910
Full Text

Cohen, H, Schmidt, CE, Lucas, SR, and Palmer, JL. "Combination chemotherapy with vincristine, cyclophosphamide, and prednisone producing long term remission of a transplanted canine lymphoma." American Journal of Veterinary Research 36, no. 10 (1975): 1483-1487.

PMID
1238040
Scholars@Duke

Cohen, HJ, Johnson, JL, and Rajagopalan, KV. "Molecular basis of the biological function of molybdenum. Developmental patterns of sulfite oxidase and xanthine oxidase in the rat." Archives of biochemistry and biophysics 164, no. 2 (October 1974): 440-446. (Academic Article)

PMID
4376662
Scholars@Duke

Johnson, JL, Waud, WR, Cohen, HJ, and Rajagopalan, KV. "Molecular basis of the biological function of molybdenum. Molybdenum-free xanthine oxidase from livers of tungsten-treated rats." The Journal of biological chemistry 249, no. 16 (August 1974): 5056-5061. (Academic Article)

PMID
4368927
Scholars@Duke

Johnson, JL, Cohen, HJ, and Rajagopalan, KV. "Molecular basis of the biological function of molybdenum. Molybdenum-free sulfite oxidase from livers of tungsten-treated rats." The Journal of biological chemistry 249, no. 16 (August 1974): 5046-5055. (Academic Article)

PMID
4368926
Scholars@Duke

Minkin, W, Frank, SB, Wolman, SR, and Cohen, HJ. "Lymphedema in Noonan's syndrome." International journal of dermatology 13, no. 3 (July 1974): 179-183.

Full Text

Cohen, H, Chapman, AL, Bopp, WJ, Schmidt, CE, Przybylski, CE, and Mcphee, MS. "Pathogenesis of a transplanted canine lymphocytic leukemia." Cancer 33, no. 5 (May 1974): 1313-1324.

PMID
4823481
Full Text

Cooper, MR, Cohen, HJ, Huntley, CC, Waite, BM, Spees, L, and Spurr, CL. "A monoclonal IgM with antibodylike specificity for phospholipids in a patient with lymphoma." Blood 43, no. 4 (April 1974): 493-504.

PMID
4206077
Scholars@Duke

Johnson, JL, Cohen, HJ, and Rajagopalan, KV. "Studies of vanadium toxicity in the rat. Lack of correlation with molybdenum utilization." Biochemical and biophysical research communications 56, no. 4 (February 1974): 940-946.

PMID
4363644
Full Text

Johnson, JL, Rajagopalan, KV, and Cohen, HJ. "Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat." The Journal of Biological Chemistry 249, no. 3 (February 1974): 859-866.

PMID
4359773
Scholars@Duke

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