Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Noppert, Grace A., Candace S. Brown, Marianne Chanti-Ketterl, Katherine S. Hall, L Kristin Newby, Harvey Jay Cohen, and Miriam C. Morey. “The Impact of Multiple Dimensions of Socioeconomic Status on Physical Functioning Across the Life Course.” Gerontol Geriatr Med 4 (January 2018): 2333721418794021. https://doi.org/10.1177/2333721418794021.

PMID
30186891
Full Text

Hopkins, Judith O., Jake Allred, Arti Hurria, Aminah Jatoi, Jacqueline M. Lafky, Harvey Cohen, Clifford Hudis, et al. “Lymphedema, musculoskeletal events and arm function in older patients receiving adjuvant chemotherapy for breast cancer (Alliance A171302).” Breast Cancer Res Treat 166, no. 3 (December 2017): 793–808. https://doi.org/10.1007/s10549-017-4454-7.

PMID
28825227
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Foster, Jared C., Jennifer G. Le-Rademacher, Josephine L. Feliciano, Ajeet Gajra, Drew K. Seisler, Ronald DeMatteo, Jacqueline M. Lafky, et al. “Comparative "nocebo effects" in older patients enrolled in cancer therapeutic trials: Observations from a 446-patient cohort.” Cancer 123, no. 21 (November 1, 2017): 4193–98. https://doi.org/10.1002/cncr.30867.

PMID
28700816
Full Text

Durá-Ferrandis, Estrella, Jeanne S. Mandelblatt, Jonathan Clapp, George Luta, LeighAnne Faul, Gretchen Kimmick, Harvey Jay Cohen, Rachel L. Yung, and Arti Hurria. “Personality, coping, and social support as predictors of long-term quality-of-life trajectories in older breast cancer survivors: CALGB protocol 369901 (Alliance).” Psychooncology 26, no. 11 (November 2017): 1914–21. https://doi.org/10.1002/pon.4404.

PMID
28219113
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Bluethmann, Shirley M., Catherine M. Alfano, Jonathan D. Clapp, George Luta, Brent J. Small, Arti Hurria, Harvey J. Cohen, et al. “Cognitive function and discontinuation of adjuvant hormonal therapy in older breast cancer survivors: CALGB 369901 (Alliance).” Breast Cancer Res Treat 165, no. 3 (October 2017): 677–86. https://doi.org/10.1007/s10549-017-4353-y.

PMID
28653250
Full Text

Stinchcombe, Thomas E., Ying Zhang, Everett E. Vokes, Joan H. Schiller, Jeffrey D. Bradley, Karen Kelly, Walter J. Curran, et al. “Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies.” J Clin Oncol 35, no. 25 (September 1, 2017): 2885–92. https://doi.org/10.1200/JCO.2016.71.4758.

PMID
28493811
Full Text

King, Katherine E., Gerda G. Fillenbaum, and Harvey J. Cohen. “A Cumulative Deficit Laboratory Test-based Frailty Index: Personal and Neighborhood Associations.” J Am Geriatr Soc 65, no. 9 (September 2017): 1981–87. https://doi.org/10.1111/jgs.14983.

PMID
28665517
Full Text

Belsky, Daniel W., Avshalom Caspi, Harvey J. Cohen, William E. Kraus, Sandhya Ramrakha, Richie Poulton, and Terrie E. Moffitt. “Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.” Aging Cell 16, no. 4 (August 2017): 644–51. https://doi.org/10.1111/acel.12591.

PMID
28401731
Full Text

Mandelblatt, Jeanne S., Ling Cai, George Luta, Gretchen Kimmick, Jonathan Clapp, Claudine Isaacs, Brandeyln Pitcher, et al. “Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance).” Breast Cancer Res Treat 164, no. 1 (July 2017): 107–17. https://doi.org/10.1007/s10549-017-4222-8.

PMID
28364214
Full Text

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