Harvey Jay Cohen, MD

Professor of Medicine
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Emeritus Director, Center for the Study of Aging & Human Development
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Member of the Duke Cancer Institute
Campus mail 2509 Blue Zone Duke Clinic, Center for Aging, Trent Drive, Durham, NC 27710
Phone (919) 660-7503
Email address harvey.cohen@duke.edu

Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline and reilience with aging, geriatric assessment, and cancer and anemia in the elderly.

Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status. He is Co-PI of the Pepper Center Physical Performance Across the LifeSpan (PALS) study, which is a longitudinal cohort study of community dwelling adults from age 30-90+and includes functional measures and biomarkers on inflammation and metabolism.
 
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen was co-chair, and now member of the Cancer in the Older Adult Committee of the Alliance for Clinical Trials in Oncology (ALLIANCE). A number of active studies and ongoing data bases aree being utilized to address these questions.

Anemia in the older adult is being addressed through an NIA funded U01 consortium (Dr. Cohen Co-PI). the current main study is an observational study followed by a pragmatic treatment trial for anemia in older adults with CHF, in collaboration with the Cardiovascular Research Network (CVRN) of the Health services research network (HSRN) 

Education and Training

  • M.D., State University of New York, Brooklyn, 1965

Publications

Kimmick, Gretchen G., Brittny Major, Jonathan Clapp, Jeff Sloan, Brandelyn Pitcher, Karla Ballman, Myra Barginear, et al. “Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503).” Breast Cancer Res Treat 163, no. 2 (June 2017): 391–98. https://doi.org/10.1007/s10549-017-4188-6.

PMID
28283904
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Soto Perez De Celis, Enrique, Can-Lan Sun, William P. Tew, Supriya Gupta Mohile, Ajeet Gajra, Heidi D. Klepin, Cynthia Owusu, et al. “Impact of hearing and visual impairment in older adults with cancer.” In Journal of Clinical Oncology, 35:10036–10036. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.10036.

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Hall, Katherine S., Harvey J. Cohen, Carl F. Pieper, Gerda G. Fillenbaum, William E. Kraus, Kim M. Huffman, Melissa A. Cornish, et al. “Physical Performance Across the Adult Life Span: Correlates With Age and Physical Activity.” J Gerontol a Biol Sci Med Sci 72, no. 4 (April 1, 2017): 572–78. https://doi.org/10.1093/gerona/glw120.

PMID
27356977
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Roy, Cindy N., Peter J. Snyder, Alisa J. Stephens-Shields, Andrew S. Artz, Shalender Bhasin, Harvey J. Cohen, John T. Farrar, et al. “Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial.” Jama Intern Med 177, no. 4 (April 1, 2017): 480–90. https://doi.org/10.1001/jamainternmed.2016.9540.

PMID
28241237
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Freedman, Rachel A., Jared C. Foster, Drew K. Seisler, Jacqueline M. Lafky, Hyman B. Muss, Harvey J. Cohen, Jeanne Mandelblatt, et al. “Accrual of Older Patients With Breast Cancer to Alliance Systemic Therapy Trials Over Time: Protocol A151527.” J Clin Oncol 35, no. 4 (February 2017): 421–31. https://doi.org/10.1200/JCO.2016.69.4182.

PMID
27992272
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Whitson, Heather E., Wei Duan-Porter, Kenneth Schmader, Miriam Morey, Harvey J. Cohen, and Cathleen Colón-Emeric. “Response to Letter From De Alfieri et al.: Biological Resilience of Elderly Hospitalized Patients.” J Gerontol a Biol Sci Med Sci 72, no. 1 (January 2017): 142. https://doi.org/10.1093/gerona/glw161.

PMID
27811154
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Freedman, Rachel A., D. K. Seisler, J. C. Foster, J. A. Sloan, J. M. Lafky, G. G. Kimmick, A. Hurria, et al. “Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511).” Breast Cancer Res Treat 161, no. 2 (January 2017): 363–73. https://doi.org/10.1007/s10549-016-4051-1.

PMID
27866278
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Cohen, Harvey Jay, David Smith, Can-Lan Sun, William Tew, Supriya G. Mohile, Cynthia Owusu, Heidi D. Klepin, et al. “Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy.” Cancer 122, no. 24 (December 15, 2016): 3865–72. https://doi.org/10.1002/cncr.30269.

PMID
27529755
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Tallarico, Michael, Jared Foster, Drew Seisler, Jacqueline Lafky, Arti Hurria, Aminah Jatoi, Harvey Jay Cohen, et al. “Toxicities and Related Outcomes of Elderly Patients (pts) (≥65 Years) with Hematologic Malignancies in the Contemporary Era (Alliance A151611).” In Blood, 128:536–536. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.536.536.

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Hodes, Richard J., Felipe Sierra, Steven N. Austad, Elissa Epel, Gretchen N. Neigh, Kristine M. Erlandson, Marissa J. Schafer, et al. “Disease drivers of aging.” Ann N Y Acad Sci 1386, no. 1 (December 2016): 45–68. https://doi.org/10.1111/nyas.13299.

PMID
27943360
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