Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Torok, Rachel D., Dennis M. Abraham, Clarice Gareri, Lan Mao, and Howard A. Rockman. “TWIK-Related Acid-Sensitive K+ Channels Affect the Development of Aortic Root Aneurysms in Mice.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.

Scholars@Duke

Watson, Lewis J., Kevin M. Alexander, Maradumane L. Mohan, Amber L. Bowman, Supachoke Mangmool, Kunhong Xiao, Sathyamangla V. Naga Prasad, and Howard A. Rockman. “Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation.” Cell Signal 28, no. 10 (October 2016): 1580–92. https://doi.org/10.1016/j.cellsig.2016.05.006.

PMID
27169346
Full Text

Kirk, Jonathan A., Khalid Chakir, Kyoung Hwan Lee, Edward Karst, Ronald J. Holewinski, Gianluigi Pironti, Richard S. Tunin, et al. “Pacemaker-induced transient asynchrony suppresses heart failure progression.” Science Translational Medicine 7, no. 319 (December 2015): 319ra207. https://doi.org/10.1126/scitranslmed.aad2899.

PMID
26702095
Full Text

Wisler, James W., Emily M. Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard A. Rockman, and Robert J. Lefkowitz. “The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.” Am J Physiol Heart Circ Physiol 309, no. 9 (November 2015): H1516–27. https://doi.org/10.1152/ajpheart.00291.2015.

PMID
26371162
Full Text

Xu, Wenjing, Tomasa Barrientos, Lan Mao, Howard A. Rockman, Anthony A. Sauve, and Nancy C. Andrews. “Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.” Cell Reports 13, no. 3 (October 8, 2015): 533–45. https://doi.org/10.1016/j.celrep.2015.09.023.

PMID
26456827
Full Text

Kirk, Jonathan A., Khalid Chakir, Kyounghwan Lee, Gianluigi Pironti, Mark J. Ranek, Richard S. Tunin, Pieter de Tombe, et al. “Pacemaker Induced Transient Asynchrony (PITA) Restores Contractile Reserve in Synchronous Heart Failure.” In Circulation Research, Vol. 117. LIPPINCOTT WILLIAMS & WILKINS, 2015.

Scholars@Duke

Wang, Jialu, Kunhong Xiao, and Howard A. Rockman. “Carvedilol Stimulated Gai-beta-Arrestin Biased beta 1 Adrenergic Receptor Signaling.” In Circulation Research, Vol. 117. LIPPINCOTT WILLIAMS & WILKINS, 2015.

Scholars@Duke

Pironti, Gianluigi, Ryan T. Strachan, Dennis Abraham, Samuel Mon-Wei Yu, Minyong Chen, Wei Chen, Kenji Hanada, Lan Mao, Lewis J. Watson, and Howard A. Rockman. “Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.” Circulation 131, no. 24 (June 16, 2015): 2120–30. https://doi.org/10.1161/CIRCULATIONAHA.115.015687.

PMID
25995315
Full Text

Pages