Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Professor of Cardiology, in the School of Medicine
Professor in Molecular Genetics and Microbiology
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .

Education and Training

  • Cardiology Fellow, Medicine, University of California at San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital, 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Wheeler, FC, Tang, H, Marks, OA, Hadnott, TN, Chu, P-L, Mao, L, Rockman, HA, and Marchuk, DA. "Tnni3k modifies disease progression in murine models of cardiomyopathy." PLoS Genet 5, no. 9 (September 2009): e1000647-.

PMID
19763165
Full Text

Tilley, DG, Kim, I-M, Patel, PA, Violin, JD, and Rockman, HA. "beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling." J Biol Chem 284, no. 30 (July 24, 2009): 20375-20386.

PMID
19509284
Full Text

Pandya, K, Porter, K, Rockman, HA, and Smithies, O. "Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain." Eur J Heart Fail 11, no. 7 (July 2009): 648-652.

PMID
19553396
Full Text

Fernandez, L, Marchuk, DA, Moran, JL, Beier, DR, and Rockman, HA. "An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15." Mamm Genome 20, no. 5 (May 2009): 296-304.

PMID
19387734
Full Text

Lima, B, Lam, GKW, Xie, L, Diesen, DL, Villamizar, N, Nienaber, J, Messina, E, Bowles, D, Kontos, CD, Hare, JM, Stamler, JS, and Rockman, HA. "Endogenous S-nitrosothiols protect against myocardial injury." Proc Natl Acad Sci U S A 106, no. 15 (April 14, 2009): 6297-6302.

PMID
19325130
Full Text

Acehan, D, Khuchua, Z, Houtkooper, RH, Malhotra, A, Kaufman, J, Vaz, FM, Ren, M, Rockman, HA, Stokes, DL, and Schlame, M. "Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria." Mitochondrion 9, no. 2 (April 2009): 86-95.

PMID
19114128
Full Text

Patel, PA, Tilley, DG, and Rockman, HA. "Physiologic and cardiac roles of beta-arrestins." J Mol Cell Cardiol 46, no. 3 (March 2009): 300-308. (Review)

PMID
19103204
Full Text

Mehra, MR, Rockman, HA, and Greenberg, BH. "Highlights of the 2008 Scientific Sessions of the Heart Failure Society of America. Toronto, Ontario, Canada, September 20-23, 2008." J Am Coll Cardiol 53, no. 6 (February 10, 2009): 514-522.

PMID
19195609
Full Text

Chen, J, and Rockman, HA. "Receptor signaling pathways in heart failure: Transgenic mouse models." (December 1, 2008): 89-111. (Chapter)

Full Text

Patel, PA, Tilley, DG, and Rockman, HA. "Beta-arrestin-mediated signaling in the heart." Circ J 72, no. 11 (November 2008): 1725-1729. (Review)

PMID
18838825
Scholars@Duke

Pages