Howard Allan Rockman, MD

Professor of Medicine
Edward S. Orgain Distinguished Professor of Cardiology, in the School of Medicine
Professor in Cell Biology
Campus mail 226 Clin Res Lab Bldg, Duke Box 102151, Durham, NC 27710
Phone (919) 668-2520
Email address h.rockman@duke.edu

Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure

Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or genes ablated followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.

Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.

2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.

Education and Training

  • Cardiology Fellow, Medicine, University of California - San Diego, 1987 - 1991
  • Medical Resident, Medicine, Montreal General Hospital (Canada), 1984 - 1987
  • M.D., McGill University (Canada), 1983

Publications

Casad, Michelle E., Lin Yu, Joseph P. Daniels, Matthew J. Wolf, and Howard A. Rockman. “Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy.” Mol Genet Genomics 287, no. 4 (April 2012): 351–60. https://doi.org/10.1007/s00438-012-0684-x.

PMID
22398840
Full Text

Caplan, Arthur L., Howard A. Rockman, and Laurence A. Turka. “Editorial position on publishing articles on human organ transplantation.” J Clin Invest 122, no. 1 (January 2012): 2. https://doi.org/10.1172/JCI61904.

PMID
22214852
Full Text

Casad, Michelle E., Dennis Abraham, Il-Man Kim, Stephan Frangakis, Brian Dong, Na Lin, Matthew J. Wolf, and Howard A. Rockman. “Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster.” Genetics 189, no. 3 (November 2011): 861–70. https://doi.org/10.1534/genetics.111.131482.

PMID
21890737
Full Text

Grotegut, Chad A., Amy P. Murtha, and Howard A. Rockman. “MSH-releasing Inhibitor Factor (pro-leu-gly-NH2) Acts as an Allosteric Activator for Oxytocin-induced MAPK Signaling but Does Not Affect Uterine Contractility.” Journal of Womens Health 20, no. 10 (October 1, 2011): 1392–1392.

Scholars@Duke

Noor, Nabila, Chetan B. Patel, and Howard A. Rockman. “Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.” J Mol Cell Cardiol 51, no. 4 (October 2011): 534–41. https://doi.org/10.1016/j.yjmcc.2010.11.005.

PMID
21074538
Full Text

Shenoy, Sudha K., and Howard A. Rockman. “Cardiovascular biology: heart fails without pump partner.” Nature 477, no. 7366 (September 28, 2011): 546–47. https://doi.org/10.1038/477546a.

PMID
21956327
Full Text

Lin, Na, Nima Badie, Lin Yu, Dennis Abraham, Heping Cheng, Nenad Bursac, Howard A. Rockman, and Matthew J. Wolf. “A method to measure myocardial calcium handling in adult Drosophila.” Circ Res 108, no. 11 (May 27, 2011): 1306–15. https://doi.org/10.1161/CIRCRESAHA.110.238105.

PMID
21493892
Full Text

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