Hua-Xin Liao, MD, PhD

Professor of Medicine
Member of the Duke Human Vaccine Institute
Campus mail 4076/msrb-2, 2 Genome Court, Durham, NC 27710
Phone (919) 684-5858
Email address hliao@duke.edu

Dr. Liao is a Professor of Medicine and Research Director of Duke Human Vaccine Institute. Dr. Liao is a MD virologistt rained in China. In early 1980’s, Dr. Liao made major contributions to the first isolation of epidemic hemorrhagic fever virus (hataanvirus) from Apodemus agraius using tissue culture in China. The successful identification and isolation of Hataanvirus enabled the early diagnosis and treatment of the disease, and advancement of HFRS research towards prevention by development of a killed vaccine that has been currently used in China. Dr. Liao received his PhD from the UNC-CH in biochemistry in 1991, and his postdoctoral training on HIV-1 molecular biology and pathogenesis of HIV-1 at Duke University between 1991-1994, and joined the faculty at Duke University in 1994. Dr. Liao is an expert in medical virology, molecular biology and HIV-1 vaccine development.

Current research in Liao Lab focuses in the areas of: 1) HIV-1 vaccine immunogen design and development for induction of broadly reactive antibody and T cell responses; 2) host immune responses to HIV-1 infection; 3) host cellular factors that modulate HIV-host interaction, and 4) development of vaccines and detections for viral hemorrhagic fever and other emerging infectious diseases. Dr. Liao and his colleagues has recently developed a strategy by combining the isolation of Ig VH and VL genes from sorted single cells by RT-PCR and novel linear Ig heavy- and light-chain gene expression cassettes for high throughput sequence analysis and functional testing of Ig VH and VL genes expressed as recombinant antibodies. This novel approach would greatly facilitate study of B cell response and repertoires in acute HIV-1 infection as well as in other disease setting and development of therapeutic human monoclonal antibodies.

Key words: HIV-1, AIDS, HIV-1 vaccine, neutralizing antibody and viral hemorrhagic fever.

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 1991
  • M.D., Shandong Medical University (China), 1977

Publications

Bart, PA, Huang, Y, Karuna, ST, Chappuis, S, Gaillard, J, Kochar, N, Shen, X, Allen, MA, Ding, S, Hural, J, Liao, HX, Haynes, BF, Graham, BS, Gilbert, PB, McElrath, MJ, Montefiori, DC, Tomaras, GD, Pantaleo, G, and Frahm, N. "HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial." The Journal of clinical investigation 124, no. 11 (November 2014): 4843-4856.

PMID
25271627
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Perez, LG, Chen, H, Liao, HX, and Montefiori, DC. "Envelope glycoprotein binding to the integrin α4β7 is not a general property of most HIV-1 strains." Journal of virology 88, no. 18 (September 2014): 10767-10777.

PMID
25008916
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Dennison, SM, Anasti, KM, Jaeger, FH, Stewart, SM, Pollara, J, Liu, P, Kunz, EL, Zhang, R, Vandergrift, N, Permar, S, Ferrari, G, Tomaras, GD, Bonsignori, M, Michael, NL, Kim, JH, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Liao, HX, Haynes, BF, and Alam, SM. "Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide." Journal of virology 88, no. 16 (August 2014): 9406-9417.

PMID
24920809
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Fera, D, Schmidt, AG, Haynes, BF, Gao, F, Liao, HX, Kepler, TB, and Harrison, SC. "Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains." Proceedings of the National Academy of Sciences of the United States of America 111, no. 28 (July 2014): 10275-10280.

PMID
24982157
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Haynes, BF, Moody, MA, Alam, M, Bonsignori, M, Verkoczy, L, Ferrari, G, Gao, F, Tomaras, GD, Liao, HX, and Kelsoe, G. "Progress in HIV-1 vaccine development." The Journal of allergy and clinical immunology 134, no. 1 (July 2014): 3-11. (Review)

PMID
25117798
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Jackson, KJ, Liu, Y, Roskin, KM, Glanville, J, Hoh, RA, Seo, K, Marshall, EL, Gurley, TC, Moody, MA, Haynes, BF, Walter, EB, Liao, HX, Albrecht, RA, García-Sastre, A, Chaparro-Riggers, J, Rajpal, A, Pons, J, Simen, BB, Hanczaruk, B, Dekker, CL, Laserson, J, Koller, D, Davis, MM, Fire, AZ, and Boyd, SD. "Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements." Cell host & microbe 16, no. 1 (July 2014): 105-114.

PMID
24981332
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Pollara, J, Bonsignori, M, Moody, MA, Liu, P, Alam, SM, Hwang, KK, Gurley, TC, Kozink, DM, Armand, LC, Marshall, DJ, Whitesides, JF, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Robb, ML, O'Connell, RJ, Kim, JH, Michael, NL, Montefiori, DC, Tomaras, GD, Liao, HX, Haynes, BF, and Ferrari, G. "HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities." Journal of virology 88, no. 14 (July 2014): 7715-7726.

PMID
24807721
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Madani, N, Princiotto, AM, Schön, A, LaLonde, J, Feng, Y, Freire, E, Park, J, Courter, JR, Jones, DM, Robinson, J, Liao, HX, Moody, MA, Permar, S, Haynes, B, Smith, AB, Wyatt, R, and Sodroski, J. "CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies." Journal of virology 88, no. 12 (June 2014): 6542-6555.

PMID
24696475
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Liu, P, Williams, LD, Shen, X, Bonsignori, M, Vandergrift, NA, Overman, RG, Moody, MA, Liao, HX, Stieh, DJ, McCotter, KL, French, AL, Hope, TJ, Shattock, R, Haynes, BF, and Tomaras, GD. "Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity." Journal of virology 88, no. 9 (May 2014): 5165-5170.

PMID
24554654
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Bonsignori, M, Wiehe, K, Grimm, SK, Lynch, R, Yang, G, Kozink, DM, Perrin, F, Cooper, AJ, Hwang, KK, Chen, X, Liu, M, McKee, K, Parks, RJ, Eudailey, J, Wang, M, Clowse, M, Criscione-Schreiber, LG, Moody, MA, Ackerman, ME, Boyd, SD, Gao, F, Kelsoe, G, Verkoczy, L, Tomaras, GD, Liao, HX, Kepler, TB, Montefiori, DC, Mascola, JR, and Haynes, BF. "An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1." The Journal of clinical investigation 124, no. 4 (April 2014): 1835-1843.

PMID
24614107
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