Hua-Xin Liao, MD, PhD

Professor of Medicine
Member of the Duke Human Vaccine Institute
Campus mail 4076/msrb-2, 2 Genome Court, Durham, NC 27710
Phone (919) 684-5858
Email address hliao@duke.edu

Dr. Liao is a Professor of Medicine and Research Director of Duke Human Vaccine Institute. Dr. Liao is a MD virologistt rained in China. In early 1980’s, Dr. Liao made major contributions to the first isolation of epidemic hemorrhagic fever virus (hataanvirus) from Apodemus agraius using tissue culture in China. The successful identification and isolation of Hataanvirus enabled the early diagnosis and treatment of the disease, and advancement of HFRS research towards prevention by development of a killed vaccine that has been currently used in China. Dr. Liao received his PhD from the UNC-CH in biochemistry in 1991, and his postdoctoral training on HIV-1 molecular biology and pathogenesis of HIV-1 at Duke University between 1991-1994, and joined the faculty at Duke University in 1994. Dr. Liao is an expert in medical virology, molecular biology and HIV-1 vaccine development.

Current research in Liao Lab focuses in the areas of: 1) HIV-1 vaccine immunogen design and development for induction of broadly reactive antibody and T cell responses; 2) host immune responses to HIV-1 infection; 3) host cellular factors that modulate HIV-host interaction, and 4) development of vaccines and detections for viral hemorrhagic fever and other emerging infectious diseases. Dr. Liao and his colleagues has recently developed a strategy by combining the isolation of Ig VH and VL genes from sorted single cells by RT-PCR and novel linear Ig heavy- and light-chain gene expression cassettes for high throughput sequence analysis and functional testing of Ig VH and VL genes expressed as recombinant antibodies. This novel approach would greatly facilitate study of B cell response and repertoires in acute HIV-1 infection as well as in other disease setting and development of therapeutic human monoclonal antibodies.

Key words: HIV-1, AIDS, HIV-1 vaccine, neutralizing antibody and viral hemorrhagic fever.

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 1991
  • M.D., Shandong Medical University (China), 1977

Publications

Jeffries, TL, Sacha, CR, Pollara, J, Himes, J, Jaeger, FH, Dennison, SM, McGuire, E, Kunz, E, Eudailey, JA, Trama, AM, LaBranche, C, Fouda, GG, Wiehe, K, Montefiori, DC, Haynes, BF, Liao, HX, Ferrari, G, Alam, SM, Moody, MA, and Permar, SR. "The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells." Mucosal immunology 9, no. 2 (March 2016): 414-427.

PMID
26242599
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Wang, Y, Kapoor, P, Parks, R, Silva-Sanchez, A, Alam, SM, Verkoczy, L, Liao, HX, Zhuang, Y, Burrows, P, Levinson, M, Elgavish, A, Cui, X, Haynes, BF, and Schroeder, H. "HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence." Immunogenetics 68, no. 2 (February 2016): 145-155.

PMID
26687685
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Campa, MJ, Moody, MA, Zhang, R, Liao, HX, Gottlin, EB, and Patz, EF. "Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery." Cancer immunology, immunotherapy : CII 65, no. 2 (February 2016): 171-180.

PMID
26739486
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Walsh, SR, Moodie, Z, Fiore-Gartland, AJ, Morgan, C, Wilck, MB, Hammer, SM, Buchbinder, SP, Kalams, SA, Goepfert, PA, Mulligan, MJ, Keefer, MC, Baden, LR, Swann, EM, Grant, S, Ahmed, H, Li, F, Hertz, T, Self, SG, Friedrich, D, Frahm, N, Liao, HX, Montefiori, DC, Tomaras, GD, McElrath, MJ, Hural, J, Graham, BS, and Jin, X. "Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083." The Journal of infectious diseases 213, no. 4 (February 2016): 541-550.

PMID
26475930
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Bradley, T, Fera, D, Bhiman, J, Eslamizar, L, Lu, X, Anasti, K, Zhang, R, Sutherland, LL, Scearce, RM, Bowman, CM, Stolarchuk, C, Lloyd, KE, Parks, R, Eaton, A, Foulger, A, Nie, X, Karim, SS, Barnett, S, Kelsoe, G, Kepler, TB, Alam, SM, Montefiori, DC, Moody, MA, Liao, HX, Morris, L, Santra, S, Harrison, SC, and Haynes, BF. "Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site." Cell reports 14, no. 1 (January 2016): 43-54.

PMID
26725118
Full Text

Schmidt, AG, Do, KT, McCarthy, KR, Kepler, TB, Liao, HX, Moody, MA, Haynes, BF, and Harrison, SC. "Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site." Cell reports 13, no. 12 (December 16, 2015): 2842-2850.

PMID
26711348
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Sung, JA, Pickeral, J, Liu, L, Stanfield-Oakley, SA, Lam, CY, Garrido, C, Pollara, J, LaBranche, C, Bonsignori, M, Moody, MA, Yang, Y, Parks, R, Archin, N, Allard, B, Kirchherr, J, Kuruc, JD, Gay, CL, Cohen, MS, Ochsenbauer, C, Soderberg, K, Liao, HX, Montefiori, D, Moore, P, Johnson, S, Koenig, S, Haynes, BF, Nordstrom, JL, Margolis, DM, and Ferrari, G. "Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells." The Journal of clinical investigation 125, no. 11 (November 2015): 4077-4090.

PMID
26413868
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Hraber, P, Korber, B, Wagh, K, Giorgi, EE, Bhattacharya, T, Gnanakaran, S, Lapedes, AS, Learn, GH, Kreider, EF, Li, Y, Shaw, GM, Hahn, BH, Montefiori, DC, Alam, SM, Bonsignori, M, Moody, MA, Liao, HX, Gao, F, and Haynes, BF. "Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants." Viruses 7, no. 10 (October 21, 2015): 5443-5475.

PMID
26506369
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Pollara, J, McGuire, E, Fouda, GG, Rountree, W, Eudailey, J, Overman, RG, Seaton, KE, Deal, A, Edwards, RW, Tegha, G, Kamwendo, D, Kumwenda, J, Nelson, JA, Liao, HX, Brinkley, C, Denny, TN, Ochsenbauer, C, Ellington, S, King, CC, Jamieson, DJ, van der Horst, C, Kourtis, AP, Tomaras, GD, Ferrari, G, and Permar, SR. "Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1." Journal of virology 89, no. 19 (October 2015): 9952-9961.

PMID
26202232
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Amos, JD, Himes, JE, Armand, L, Gurley, TC, Martinez, DR, Colvin, L, Beck, K, Overman, RG, Liao, HX, Moody, MA, and Permar, SR. "Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys." Journal of virology 89, no. 18 (September 2015): 9485-9498.

PMID
26157116
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