Ian James Welsby, MBBS

Professor of Anesthesiology
Professor of Medicine
Campus mail 2301 Erwin Road, 5691H Hafs Building, Durham, NC 27710
Phone (919) 681-6752
Email address ian.welsby@duke.edu

As a practicing cardiothoracic anesthesiologist, I have contributed to the better understanding of the management and of perioperative thrombosis (particularly HIT). This has been as a Duke site PI for the Rare Thrombotic Diseases Consortium led by Dr T.L Ortel and a clinical collaborator with the basic and translational science approach to HIT led by Dr G Arepally. I have also championed novel approaches to dealing with perioperative HIT such as plasmaperesis.

Similarly, I have been a local leader in establishing management of transfusion approaches to major cardiac surgery including the novel introduction of autologous plateletpheresis to limit exposure to allogeneic platelet transfusions in this highly transfused population, identifying the transfusion requirements during thoracic aortic reconstruction and promoting use of a lower dose of rFVIIa use in this population, changing established clinical practice.

My research interests focus on perioperative transfusion and hematology concerns. Recently, Dr Kor (Mayo Clinic) and I received a multiple PI R-01 award to evaluate point-of-care/bedside washing of packed red blood cells to reduce perioperative lung injury. This novel repurposing of commonly available “cell-saver” technology is, for most surgical cases, the only practical means of delivering a washed product, and promises to be a critical advancement in perioperative transfusion medicine. I also have a longstanding interest in the rejuvenation of RBCs to normalize oxygen delivery capacity of transfused RBCs. Such a development will be of tremendous importance to transfusion practice, particularly for highly transfused populations. 

In summary, I have dedicated my research career to improving the outcome of patients undergoing cardiothoracic surgery, understanding perioperative coagulopathy, and optimizing transfusion practice. 

Education and Training

  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1995 - 1995
  • Anaesthetic registrar, Anaesthetic, Royal London Hospital (United Kingdom), 1994 - 1995
  • Temporary Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1993 - 1994
  • Senior House Officer, Anesthetics, Royal London Hospital (United Kingdom), 1992 - 1993
  • Senior House Officer, Intensive Care, Royal London Hospital (United Kingdom), 1992 - 1992
  • Senior House Officer, Accident And Emergency, Royal London Hospital (United Kingdom), 1991 - 1992
  • House Officer, General And Vascular Surgery, Royal London Hospital (United Kingdom), 1991 - 1991
  • House Officer, Chest And General Medicine, Royal London Hospital (United Kingdom), 1990 - 1991
  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1990 - 1990
  • M.B.B.S., University College London (United Kingdom), 1990

Publications

Klapper, Jacob A., Anne C. Hicks, Leila Ledbetter, Jessica Poisson, Matthew G. Hartwig, Nazish Hashmi, Ian Welsby, and Brandi A. Bottiger. “Blood product transfusion and lung transplant outcomes: A systematic review.” Clin Transplant, June 27, 2021, e14404. https://doi.org/10.1111/ctr.14404.

PMID
34176163
Full Text

Brockbank, Benjamin H., Mary Cooter Wright, Jhaymie Cappiello, Brittany A. Zwischenberger, Ian J. Welsby, Jerrold H. Levy, and Negmeldeen Mamoun. “Heated Humidified Breathing Circuit Rewarming in Hypothermic Patients Post-Cardiopulmonary Bypass-Pilot Study.” J Cardiothorac Vasc Anesth, June 20, 2021. https://doi.org/10.1053/j.jvca.2021.06.020.

PMID
34294515
Full Text

Vestal, Mark L., Kimberly Hodulik, Jennifer Mando-Vandrick, Michael L. James, Thomas L. Ortel, Matthew Fuller, Maria Notini, Mark Friedland, and Ian J. Welsby. “Andexanet alfa and four-factor prothrombin complex concentrate for reversal of apixaban and rivaroxaban in patients diagnosed with intracranial hemorrhage.” J Thromb Thrombolysis, June 8, 2021. https://doi.org/10.1007/s11239-021-02495-3.

PMID
34101050
Full Text

Thomas, Tiffany, Francesca Cendali, Xiaoyun Fu, Fabia Gamboni, Evan J. Morrison, Jonathan Beirne, Travis Nemkov, et al. “Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.” Transfusion 61, no. 6 (June 2021): 1867–83. https://doi.org/10.1111/trf.16402.

PMID
33904180
Full Text

Manning, Michael W., Yi-Ju Li, Dean Linder, John C. Haney, Yi-Hung Wu, Mihai V. Podgoreanu, Madhav Swaminathan, et al. “Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.” J Cardiothorac Vasc Anesth 35, no. 5 (May 2021): 1310–18. https://doi.org/10.1053/j.jvca.2020.11.036.

PMID
33339661
Full Text

Levitt, Joseph E., Emir Festic, Manisha Desai, Haley Hedlin, Kenneth W. Mahaffey, Angela J. Rogers, Ognjen Gajic, Michael A. Matthay, and Michael A. ARREST Pneumonia Clinical Trial Investigators. “The ARREST Pneumonia Clinical Trial. Rationale and Design.” Ann Am Thorac Soc 18, no. 4 (April 2021): 698–708. https://doi.org/10.1513/AnnalsATS.202009-1115SD.

PMID
33493423
Full Text

Evans, Brooke A., Reed W. Kamyszek, Mark Piegore, Keaton Stoner, Matthew Fuller, Ian J. Welsby, and Micah Mooberry. “Global sources of cryoprecipitate demonstrate variability in coagulant factor levels and functional hemostasis.” Blood Coagul Fibrinolysis 32, no. 2 (March 1, 2021): 87–102. https://doi.org/10.1097/MBC.0000000000000982.

PMID
33186132
Full Text

Welsby, Ian J., Philip J. Norris, William J. Mauermann, Mihai V. Podgoreanu, Chelsea M. Conn, Laurie Meade, Tamara Cannon, et al. “Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles.” Anesthesiology 134, no. 3 (March 1, 2021): 395–404. https://doi.org/10.1097/ALN.0000000000003689.

PMID
33503656
Full Text

Evans, Brooke A., Andrea K. Ansari, Reed W. Kamyszek, Michele Salvagno, John Welsby, Matthew Fuller, and Ian Welsby. “Modulation of red blood cell oxygen affinity with a novel allosteric modifier of hemoglobin is additive to the Bohr effect.” Blood Cells Mol Dis 87 (March 2021): 102520. https://doi.org/10.1016/j.bcmd.2020.102520.

PMID
33242840
Full Text

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