Ian James Welsby, MBBS

Professor of Anesthesiology
Professor of Medicine
Campus mail 2301 Erwin Road, 5691H Hafs Building, Durham, NC 27710
Phone (919) 681-6752
Email address ian.welsby@duke.edu

As a practicing cardiothoracic anesthesiologist, I have contributed to the better understanding of the management and of perioperative thrombosis (particularly HIT). This has been as a Duke site PI for the Rare Thrombotic Diseases Consortium led by Dr T.L Ortel and a clinical collaborator with the basic and translational science approach to HIT led by Dr G Arepally. I have also championed novel approaches to dealing with perioperative HIT such as plasmaperesis.

Similarly, I have been a local leader in establishing management of transfusion approaches to major cardiac surgery including the novel introduction of autologous plateletpheresis to limit exposure to allogeneic platelet transfusions in this highly transfused population, identifying the transfusion requirements during thoracic aortic reconstruction and promoting use of a lower dose of rFVIIa use in this population, changing established clinical practice.

My research interests focus on perioperative transfusion and hematology concerns. Recently, Dr Kor (Mayo Clinic) and I received a multiple PI R-01 award to evaluate point-of-care/bedside washing of packed red blood cells to reduce perioperative lung injury. This novel repurposing of commonly available “cell-saver” technology is, for most surgical cases, the only practical means of delivering a washed product, and promises to be a critical advancement in perioperative transfusion medicine. I also have a longstanding interest in the rejuvenation of RBCs to normalize oxygen delivery capacity of transfused RBCs. Such a development will be of tremendous importance to transfusion practice, particularly for highly transfused populations. 

In summary, I have dedicated my research career to improving the outcome of patients undergoing cardiothoracic surgery, understanding perioperative coagulopathy, and optimizing transfusion practice. 

Education and Training

  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1995 - 1995
  • Anaesthetic registrar, Anaesthetic, Royal London Hospital (United Kingdom), 1994 - 1995
  • Temporary Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1993 - 1994
  • Senior House Officer, Anesthetics, Royal London Hospital (United Kingdom), 1992 - 1993
  • Senior House Officer, Intensive Care, Royal London Hospital (United Kingdom), 1992 - 1992
  • Senior House Officer, Accident And Emergency, Royal London Hospital (United Kingdom), 1991 - 1992
  • House Officer, General And Vascular Surgery, Royal London Hospital (United Kingdom), 1991 - 1991
  • House Officer, Chest And General Medicine, Royal London Hospital (United Kingdom), 1990 - 1991
  • Anaesthetic Registrar, Anaesthetics, Royal London Hospital (United Kingdom), 1990 - 1990
  • M.B.B.S., University College London (United Kingdom), 1990

Publications

Levy, Jerrold H., Roman M. Sniecinski, Ian J. Welsby, and Marcel Levi. “Antithrombin: anti-inflammatory properties and clinical applications.” Thrombosis and Haemostasis, April 2016. https://doi.org/10.1160/th15-08-0687.

PMID
26676884
Full Text

Hanna, Jennifer M., Jeffrey E. Keenan, Hanghang Wang, Nicholas D. Andersen, Jeffrey G. Gaca, Frederick W. Lombard, Ian J. Welsby, and G Chad Hughes. “Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 151, no. 2 (February 2016): 376–82. https://doi.org/10.1016/j.jtcvs.2015.08.079.

PMID
26428473
Full Text

Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.” Anesthesiology 124, no. 2 (February 2016): 339–52. https://doi.org/10.1097/ALN.0000000000000959.

PMID
26599400
Full Text

Schechter, Matthew A., Asad A. Shah, Brian R. Englum, Judson B. Williams, Asvin M. Ganapathi, John D. Davies, Ian J. Welsby, and G Chad Hughes. “Prolonged postoperative respiratory support after proximal thoracic aortic surgery: Is deep hypothermic circulatory arrest a risk factor?” J Crit Care 31, no. 1 (February 2016): 125–29. https://doi.org/10.1016/j.jcrc.2015.10.021.

PMID
26700606
Full Text

Heath, Michele, Atilio Barbeito, Ian Welsby, Cory Maxwell, Alexander Iribarne, and Karthik Raghunathan. “Using Zero-Balance Ultrafiltration With Dialysate as a Replacement Solution for Toxin and Eptifibatide Removal on a Dialysis-Dependent Patient During Cardiopulmonary Bypass.” J Cardiothorac Vasc Anesth 30, no. 1 (January 2016): 162–68. https://doi.org/10.1053/j.jvca.2014.12.007.

PMID
25857672
Full Text

Ghadmi, Kamrouz, Nazish Hashmi, Jerrold Levy, Thomas L. Ortel, and Ian J. Welsby. “Prothrombin Complex Concentrates and Cardiac Surgery.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.

Scholars@Duke

Pages