Jae-Sung Yu, PhD

Assistant Professor in Medicine
Member of the Duke Human Vaccine Institute
Campus mail 2 Genome Court, Msrb Ii Rm 4021, Durham, NC 27710
Phone (919) 668-1966
Email address jaeyu@duke.edu

Jae-Sung Yu, PhD is Assistant Professor of Medicine at Duke University Medical Center. He received his PhD in Microbiology from the University of Connecticut in 1998. Yu is currently developing rM. smegmatis vectors for HIV-1 vaccines funded by a grant from the Bill and Melinda Gates grant awarded in July 2006. Yu is also working on a program project grant, “HIV, TB and Malaria Vaccine Development for Africa,” expressing HIV and malaria antigens in an attenuated mycobacterium tuberculosis (MTB) vector. Yu’s role in this project is constructing the mycobacterial plasmids expressing HIV-1 Env and assessed mucosal T cell immunity in animal model.

Education and Training

  • Ph.D., University of Connecticut, 1998
  • M.S., Seoul National University, 1987

Publications

Kepler, TB, Munshaw, S, Wiehe, K, Zhang, R, Yu, J-S, Woods, CW, Denny, TN, Tomaras, GD, Alam, SM, Moody, MA, Kelsoe, G, Liao, H-X, and Haynes, BF. "Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation." Frontiers in immunology 5 (January 2014): 170-.

PMID
24795717
Full Text

Taylor, N, Bahunde, F, Thompson, A, Yu, J-S, Jacobs, WR, Letvin, NL, Haynes, BF, and Lee, S. "Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion." Clin Vaccine Immunol 19, no. 9 (September 2012): 1416-1425.

PMID
22787192
Full Text

Moody, MA, Yates, NL, Amos, JD, Drinker, MS, Eudailey, JA, Gurley, TC, Marshall, DJ, Whitesides, JF, Chen, X, Foulger, A, Yu, J-S, Zhang, R, Meyerhoff, RR, Parks, R, Scull, JC, Wang, L, Vandergrift, NA, Pickeral, J, Pollara, J, Kelsoe, G, Alam, SM, Ferrari, G, Montefiori, DC, Voss, G, Liao, H-X, Tomaras, GD, and Haynes, BF. "HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages." J Virol 86, no. 14 (July 2012): 7496-7507.

PMID
22553329
Full Text

Liao, H-X, Chen, X, Munshaw, S, Zhang, R, Marshall, DJ, Vandergrift, N, Whitesides, JF, Lu, X, Yu, J-S, Hwang, K-K, Gao, F, Markowitz, M, Heath, SL, Bar, KJ, Goepfert, PA, Montefiori, DC, Shaw, GC, Alam, SM, Margolis, DM, Denny, TN, Boyd, SD, Marshal, E, Egholm, M, Simen, BB, Hanczaruk, B, Fire, AZ, Voss, G, Kelsoe, G, Tomaras, GD, Moody, MA, Kepler, TB, and Haynes, BF. "Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated." J Exp Med 208, no. 11 (October 24, 2011): 2237-2249.

PMID
21987658
Full Text

Gray, ES, Moody, MA, Wibmer, CK, Chen, X, Marshall, D, Amos, J, Moore, PL, Foulger, A, Yu, J-S, Lambson, B, Abdool Karim, S, Whitesides, J, Tomaras, GD, Haynes, BF, Morris, L, and Liao, H-X. "Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual." J Virol 85, no. 15 (August 2011): 7719-7729.

PMID
21613396
Full Text

Yu, J-S, Whitesides, J, Lee, S-H, Taylor, N, Jacobs, WR, Letvin, NL, and Haynes, BF. "Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression." Clin Vaccine Immunol 18, no. 1 (January 2011): 43-49.

PMID
21068210
Full Text

Moody, MA, Zhang, R, Walter, EB, Woods, CW, Ginsburg, GS, McClain, MT, Denny, TN, Chen, X, Munshaw, S, Marshall, DJ, Whitesides, JF, Drinker, MS, Amos, JD, Gurley, TC, Eudailey, JA, Foulger, A, DeRosa, KR, Parks, R, Meyerhoff, RR, Yu, J-S, Kozink, DM, Barefoot, BE, Ramsburg, EA, Khurana, S, Golding, H, Vandergrift, NA, Alam, SM, Tomaras, GD, Kepler, TB, Kelsoe, G, Liao, H-X, and Haynes, BF. "H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination." PLoS One 6, no. 10 (2011): e25797-.

PMID
22039424
Full Text

Yu, J-S, Ma, B-J, Scearce, RM, Liao, H-X, and Haynes, BF. "Anti-Ebola MAb 17A3 reacts with bovine and human alpha-2-macroglobulin proteins." J Virol Methods 168, no. 1-2 (September 2010): 248-250.

PMID
20447422
Full Text

Barefoot, B, Thornburg, NJ, Barouch, DH, Yu, J-S, Sample, C, Johnston, RE, Liao, HX, Kepler, TB, Haynes, BF, and Ramsburg, E. "Comparison of multiple vaccine vectors in a single heterologous prime-boost trial." Vaccine 26, no. 48 (November 11, 2008): 6108-6118.

PMID
18809447
Full Text

Yu, J-S, Peacock, JW, Jacobs, WR, Frothingham, R, Letvin, NL, Liao, H-X, and Haynes, BF. "Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites." Clin Vaccine Immunol 14, no. 7 (July 2007): 886-893.

PMID
17507541
Full Text

Pages