James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Publications

Lu, Weiqin, Yaying Yang, Xiaojie Wang, Yan Liu, Yongde Luo, Robert A. Wolff, James L. Abbruzzese, and Craig D. Logsdon. “Abstract 891: FGF21 prevents high fat diet-induced pancreatic cancer in mice expressing oncogenic Kras.” In Prevention Research. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-891.

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Reddy, S. M., S. Kopetz, J. Morris, N. Parikh, W. Qiao, M. J. Overman, D. Fogelman, et al. “Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer..” Invest New Drugs 33, no. 4 (August 2015): 977–84. https://doi.org/10.1007/s10637-015-0257-z.

PMID
26062928
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Zhao, Jun, Chunhui Wu, James Abbruzzese, Rosa F. Hwang, and Chun Li. “Cyclopamine-loaded core-cross-linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells..” Mol Pharm 12, no. 6 (June 1, 2015): 2093–2100. https://doi.org/10.1021/mp500875f.

PMID
25936695
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Zhang, Tian, Rengasamy Boominathan, Brad Foulk, Mark Carle Connelly, Chandra Rao, Gabor Kemeny, John H. Strickler, et al. “Evaluation of a novel c-MET based circulating tumor cell (CTC) biomarker in patients with gastrointestinal (GI) and genitourinary (GU) malignancies..” In Journal of Clinical Oncology, Vol. 33. AMER SOC CLINICAL ONCOLOGY, 2015.

Scholars@Duke

Li, D., Y. Mao, P. Chang, C. Liu, M. M. Hassan, S. J. Yeung, and J. L. Abbruzzese. “Impacts of new-onset and long-term diabetes on clinical outcome of pancreatic cancer.” American Journal of Cancer Research 5, no. 10 (January 1, 2015): 3260–69.

Scholars@Duke

Koay, Eugene J., Flavio E. Baio, Alexander Ondari, Mark J. Truty, Vittorio Cristini, Ryan M. Thomas, Rong Chen, et al. “Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer..” Phys Biol 11, no. 6 (November 26, 2014). https://doi.org/10.1088/1478-3975/11/6/065002.

PMID
25427073
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Wang, H., J. S. Estrella, D. Chatterjee, M. H. Katz, A. Rashid, R. A. Wolff, G. R. Varadhachary, et al. “Hepatobiliary/Pancreas Pathology: SY11-3 PANCREATIC DUCTAL ADENOCARCINOMA: NEOADJUVANT THERAPIES AND PATHOLOGY..” Pathology 46 Suppl 2 (October 2014). https://doi.org/10.1097/01.PAT.0000454135.19954.47.

PMID
25188109
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Kaseb, Ahmed O., Lianchun Xiao, Manal M. Hassan, Young Kwang Chae, Ju-Seog Lee, Jean-Nicolas Vauthey, Sunil Krishnan, et al. “Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma..” J Natl Cancer Inst 106, no. 5 (May 9, 2014). https://doi.org/10.1093/jnci/dju088.

PMID
24815863
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Guo, Rongjun, Michael Overman, Deyali Chatterjee, Asif Rashid, Stuti Shroff, Hua Wang, Matthew H. Katz, et al. “Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma..” Hum Pathol 45, no. 5 (May 2014): 1015–23. https://doi.org/10.1016/j.humpath.2013.12.016.

PMID
24746206
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