Medical Oncology

James Abbruzzese, MD

Professor of Medicine
D. C. I. Professor of Medical Oncology
Chief, Division of Medical Oncology
Member of the Duke Cancer Institute
Campus mail 440 Mudd Building, Box 3406, Durham, NC 27710
Email address james.abbruzzese@duke.edu

My research interests include the clinical study and treatment of pancreatic cancer.

In Their Words

Education and Training

  • Resident, Internal Medicine, Johns Hopkins University School of Medicine, 1979 - 1981
  • Intern, Internal Medicine, Johns Hopkins University School of Medicine, 1978 - 1979
  • M.D., University of Chicago, 1978

Grants

Publications

Khalil, MA, Qiao, W, Carlson, P, George, B, Javle, M, Overman, M, Varadhachary, G, Wolff, RA, Abbruzzese, JL, and Fogelman, DR. "The addition of erlotinib to gemcitabine and cisplatin does not appear to improve median survival in metastatic pancreatic cancer." Investigational new drugs 31, no. 5 (October 2013): 1375-1383.

PMID
23645398
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Kaseb, AO, Shindoh, J, Patt, YZ, Roses, RE, Zimmitti, G, Lozano, RD, Hassan, MM, Hassabo, HM, Curley, SA, Aloia, TA, Abbruzzese, JL, and Vauthey, J-N. "Modified cisplatin/interferon α-2b/doxorubicin/5-fluorouracil (PIAF) chemotherapy in patients with no hepatitis or cirrhosis is associated with improved response rate, resectability, and survival of initially unresectable hepatocellular carcinoma." Cancer 119, no. 18 (September 2013): 3334-3342.

PMID
23821538
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Overman, MJ, Zhang, J, Kopetz, S, Davies, M, Jiang, Z-Q, Stemke-Hale, K, Rümmele, P, Pilarsky, C, Grützmann, R, Hamilton, S, Hwang, R, Abbruzzese, JL, Varadhachary, G, Broom, B, and Wang, H. "Correction: Gene Expression Profiling of Ampullary Carcinomas Classifies Ampullary Carcinomas into Biliary-Like and Intestinal-Like Subtypes That Are Prognostic of Outcome." Edited by J-S Lee. PLoS ONE 8, no. 7 (July 3, 2013).

Full Text

Tzeng, C-WD, Abbott, DE, Cantor, SB, Fleming, JB, Lee, JE, Pisters, PWT, Varadhachary, GR, Abbruzzese, JL, Wolff, RA, Ahmad, SA, and Katz, MHG. "Frequency and intensity of postoperative surveillance after curative treatment of pancreatic cancer: a cost-effectiveness analysis." Annals of surgical oncology 20, no. 7 (July 2013): 2197-2203.

PMID
23408126
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Foo, WC, Rashid, A, Wang, H, Katz, MH, Lee, JE, Pisters, PW, Wolff, RA, Abbruzzese, JL, Fleming, JB, and Wang, H. "Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma." Human pathology 44, no. 6 (June 2013): 1024-1030.

PMID
23260327
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Chang, Z, Li, Z, Wang, X, Kang, Y, Yuan, Y, Niu, J, Wang, H, Chatterjee, D, Fleming, JB, Li, M, Abbruzzese, JL, and Chiao, PJ. "Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells." Clinical cancer research : an official journal of the American Association for Cancer Research 19, no. 3 (February 2013): 549-559.

PMID
23340292
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Li, L, Othman, M, Rashid, A, Wang, H, Li, Z, Katz, MH, Lee, JE, Pisters, PW, Abbruzzese, JL, Fleming, JB, and Wang, H. "Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells." Histopathology 62, no. 3 (February 2013): 465-471.

PMID
23134473
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Yao, Y, Suraokar, M, Darnay, BG, Hollier, BG, Shaiken, TE, Asano, T, Chen, C-H, Chang, BH-J, Lu, Y, Mills, GB, Sarbassov, D, Mani, SA, Abbruzzese, JL, and Reddy, SAG. "BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation." Science signaling 6, no. 257 (January 8, 2013): ra2-.

PMID
23300339
Full Text

Overman, MJ, Zhang, J, Kopetz, S, Davies, M, Jiang, Z-Q, Stemke-Hale, K, Rümmele, P, Pilarsky, C, Grützmann, R, Hamilton, S, Hwang, R, Abbruzzese, JL, Varadhachary, G, Broom, B, and Wang, H. "Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome." PloS one 8, no. 6 (January 2013): e65144-.

PMID
23776447
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Overman, MJ, Modak, J, Kopetz, S, Murthy, R, Yao, JC, Hicks, ME, Abbruzzese, JL, and Tam, AL. "Use of research biopsies in clinical trials: are risks and benefits adequately discussed?." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31, no. 1 (January 2013): 17-22.

PMID
23129736
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Pages