Jennifer Leigh Ingram, PhD

Assistant Professor in Medicine
Assistant Professor in Pathology
Assistant Professor in the Department of Surgery
Campus mail 201 Msrb1 Bldg, Durham, NC 27710
Phone (919) 668-1439
Email address jennifer.ingram@duke.edu

Dr. Ingram's research interests focus on the study of airway remodeling in human asthma. Proliferation, migration, and invasion of airway fibroblasts are key features of airway remodeling that contribute to diminished lung function over time. Dr. Ingram uses molecular biology approaches to define the effects of interleukin-13 (IL-13), a cytokine abundantly produced in the asthmatic airway, in the human airway fibroblast. She has identified important regulatory functions of several proteins prevalent in asthma that control fibroblast growth and pro-fibrotic growth factor production in response to IL-13. By understanding these pathways and their role in human asthma and the chronic effects of airway remodeling, novel treatment strategies may be developed.

Education and Training

  • Ph.D., North Carolina State University, 2000

Publications

Ingram, J. L., V. McQuade, B. Theriot, J. Niu, J. Daly, J. Wong, J. Tong, R. M. Tighe, L. G. Que, and D. D’Alessio. “Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.

Scholars@Duke

Walker, Julia K. L., Barbara S. Theriot, Michael Ghio, Carol S. Trempus, Jordan E. Wong, Victoria L. McQuade, Jiurong Liang, et al. “Targeted HAS2 Expression Lessens Airway Responsiveness in Chronic Murine Allergic Airway Disease.” Am J Respir Cell Mol Biol 57, no. 6 (December 2017): 702–10. https://doi.org/10.1165/rcmb.2017-0095OC.

PMID
28787175
Full Text

Trempus, Carol S., Weifeng Song, Ahmed Lazrak, Zhihong Yu, Judy R. Creighton, Bethany M. Young, Rebecca L. Heise, et al. “A novel role for primary cilia in airway remodeling.” Am J Physiol Lung Cell Mol Physiol 313, no. 2 (August 1, 2017): L328–38. https://doi.org/10.1152/ajplung.00284.2016.

PMID
28473325
Full Text

Mcquade, Victoria L., Jingjing Niu, Barbara Theriot, David D’Alessio, Mary Jane Cunningham, Loretta Que, and Jennifer L. Ingram. “An in Vitro Model of Airway Fibroblast Functions to Assess Airway Remodeling in Asthma.” In In Vitro Cellular & Developmental Biology Animal, 53:663–663. SPRINGER, 2017.

Scholars@Duke

Ingram, J. L. “Modeling Human Lung Fibroblast Responses in Asthma and Airway Disease.” In In Vitro Cellular & Developmental Biology Animal, 53:S5–6. SPRINGER, 2017.

Scholars@Duke

Hackett, Tillie-Louise, Sarah C. Ferrante, Claire E. Hoptay, John F. Engelhardt, Jennifer L. Ingram, Yulong Zhang, Sarah E. Alcala, et al. “A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma.” Am J Respir Cell Mol Biol 56, no. 3 (March 2017): 291–99. https://doi.org/10.1165/rcmb.2016-0065MA.

PMID
27788019
Full Text

Ingram, J. L., M. Ghio, A. Hegde, J. Wong, D. D’Alessio, L. Que, J. K. Walker, and V. McQuade. “Opposing Actions Of Leptin And Glucagon-Like Peptide-1 (glp-1) To Regulate Interleukin-13 (il-13)-Directed Airway Fibroblast Responses.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.

Scholars@Duke

Ingram, J. L., M. Ghio, R. W. Sigmon, J. Wong, B. Theriot, A. Hegde, J. K. L. Walker, and M. Kraft. “Interleukin-17 And Leptin Contribute To Airway Fibrosis And Altered Interleukin-13 Receptor Expression In Obese Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Ferrante, S. C., T. -. L. Hackett, C. E. Hoptay, J. Engelhardt, J. L. Ingram, S. Alcala, Y. Zhang, et al. “An In Vivo Model Of Human Airways For Investigating Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.

Scholars@Duke

Ingram, Jennifer L., David Slade, Tony D. Church, Dave Francisco, Karissa Heck, R Wesley Sigmon, Michael Ghio, et al. “Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.” Am J Respir Cell Mol Biol 54, no. 1 (January 2016): 41–50. https://doi.org/10.1165/rcmb.2014-0290OC.

PMID
26074138
Full Text

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