Education and Training
- Ph.D., University of Delaware, 2005
Wang, J, Ren, X-R, Piao, H, Zhao, S, Osada, T, Premont, RT, Mook, RA, Morse, MA, Lyerly, HK, and Chen, W. "Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy." The Biochemical Journal 476, no. 3 (February 8, 2019): 535-546.
Wang, J, Mook, RA, Ren, X-R, Zhang, Q, Jing, G, Lu, M, Spasojevic, I, Lyerly, HK, Hsu, D, and Chen, W. "Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth." Bioorganic & Medicinal Chemistry 26, no. 20 (November 2018): 5435-5442.
Chen, W, Mook, RA, Premont, RT, and Wang, J. "Niclosamide: Beyond an antihelminthic drug." Cellular signalling 41 (January 2018): 89-96. (Review)
Mook, RA, Ren, X-R, Wang, J, Piao, H, Barak, LS, Kim Lyerly, H, and Chen, W. "Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis." Bioorganic & medicinal chemistry 25, no. 6 (March 2017): 1804-1816.
Ren, XR, Wang, J, Osada, T, Mook, RA, Morse, MA, Barak, LS, Lyerly, HK, and Chen, W. "Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth." Breast cancer research : BCR 17, no. 1 (December 2015): 528-.
Mook, RA, Wang, J, Ren, X-R, Chen, M, Spasojevic, I, Barak, LS, Lyerly, HK, and Chen, W. "Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure." Bioorganic & Medicinal Chemistry 23, no. 17 (September 2015): 5829-5838.
Barak, LS, Bai, Y, Snyder, JC, Wang, J, Chen, W, and Caron, MG. "Triphenylmethane dye activation of beta-arrestin." Biochemistry 52, no. 32 (August 2013): 5403-5414.
Lu, J, Chen, M, Ren, X-R, Wang, J, Lyerly, HK, Barak, L, and Chen, W. "Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. (Published online)" PLoS One 8, no. 5 (2013): e63353-.
Wang, J, Mook, RA, Lu, J, Gooden, DM, Ribeiro, A, Guo, A, Barak, LS, Lyerly, HK, and Chen, W. "Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling." Bioorg Med Chem 20, no. 22 (November 15, 2012): 6751-6757.
Wang, J, Lu, J, Mook, RA, Zhang, M, Zhao, S, Barak, LS, Freedman, JH, Lyerly, HK, and Chen, W. "The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks." Toxicological Sciences : an Official Journal of the Society of Toxicology 128, no. 2 (August 2012): 517-523.