Education and Training
- Ph.D., University of Delaware, 2005
Wang, Jiangbo, Xiu-Rong Ren, Hailan Piao, Shengli Zhao, Takuya Osada, Richard T. Premont, Robert A. Mook, Michael A. Morse, Herbert Kim Lyerly, and Wei Chen. “Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.” Biochem J 476, no. 3 (February 8, 2019): 535–46. https://doi.org/10.1042/BCJ20180385.
Wang, Jiangbo, Robert A. Mook, Xiu-Rong Ren, Qingfu Zhang, Genevieve Jing, Min Lu, Ivan Spasojevic, H Kim Lyerly, David Hsu, and Wei Chen. “Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.” Bioorg Med Chem 26, no. 20 (November 1, 2018): 5435–42. https://doi.org/10.1016/j.bmc.2018.09.016.
Mook, Robert A., Xiu-Rong Ren, Jiangbo Wang, Hailan Piao, Larry S. Barak, H. Kim Lyerly, and Wei Chen. “Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.” Bioorg Med Chem 25, no. 6 (March 15, 2017): 1804–16. https://doi.org/10.1016/j.bmc.2017.01.046.
Ren, X. R., J. Wang, T. Osada, R. A. Mook, M. A. Morse, L. S. Barak, H. K. Lyerly, and W. Chen. “Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.” Breast Cancer Res 17, no. 1 (December 2015): 528. https://doi.org/10.1186/s13058-015-0528-9.
Mook, Robert A., Jiangbo Wang, Xiu-Rong Ren, Minyong Chen, Ivan Spasojevic, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.” Bioorg Med Chem 23, no. 17 (September 1, 2015): 5829–38. https://doi.org/10.1016/j.bmc.2015.07.001.
Wang, Jiangbo, Robert A. Mook, Jiuyi Lu, David M. Gooden, Anthony Ribeiro, Anchen Guo, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.” Bioorg Med Chem 20, no. 22 (November 15, 2012): 6751–57. https://doi.org/10.1016/j.bmc.2012.09.030.
Wang, Jiangbo, Jiuyi Lu, Robert A. Mook, Min Zhang, Shengli Zhao, Larry S. Barak, Jonathan H. Freedman, H Kim Lyerly, and Wei Chen. “The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.” Toxicol Sci 128, no. 2 (August 2012): 517–23. https://doi.org/10.1093/toxsci/kfs165.