Joe Brice Weinberg, MD

Professor of Medicine
Associate Professor of Obstetrics and Gynecology
Professor of Immunology
Affiliate, Duke Global Health Institute
Member of the Duke Cancer Institute
Campus mail Duke Box 3396, Durham, NC 27708
Phone (919) 286-6833
Email address weinb001@duke.edu

Dr. Weinberg is a board-certified hematologist and medical oncologist who serves as Professor of Medicine and Immunology and Associate Professor of Obstetrics and Gynecology at the Duke University Medical Center, and staff physician in hematology-oncology at the Durham V.A. Medical Center. His clinical interests are in hematology and oncology, and his research focuses on blood cells, nitric oxide (NO), and leukemia. The work includes studies of resistance to infection, pathways of inflammation, and regulation of normal and leukemic cell life and death. His current work includes studies of leukemia (primarily chronic lymphocytic leukemia); the roles of NO and arginine in the resistance to malaria; and the interactions of NO, prostaglandins, and mechanical force in inflammation and arthritis.

Education and Training

  • Fellowship, Hematology Oncology, University of Utah School of Medicine, 1973 - 1976
  • Internship & Residency, University of Arkansas at Little Rock, 1969 - 1971
  • M.D., University of Arkansas at Little Rock, 1969
  • B.S., University of Arkansas, Fayetteville, 1966

Publications

Brander, Danielle M., Sallie D. Allgood, David A. Rizzieri, Tiffany Stewart, J Brice Weinberg, and Mark C. Lanasa. “Final Clinical Results with Laboratory Correlates in the Phase I Trial of Lenalidomide Plus Plerixafor in Previously Treated Chronic Lymphocytic Leukemia (CLL).” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Heyman, Benjamin M., Alicia D. Volkheimer, J Brice Weinberg, and Mark Lanasa. “Double IGHV Gene Rearrangements in Chronic Lymphocytic Leukemia.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Yeo, Tsin W., Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, J Brice Weinberg, Donald L. Granger, Ric N. Price, and Nicholas M. Anstey. “Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria..” J Infect Dis 210, no. 10 (November 15, 2014): 1627–32. https://doi.org/10.1093/infdis/jiu308.

PMID
24879801
Full Text

Weinberg, J Brice, Alicia D. Volkheimer, Youwei Chen, Matthew P. Rubach, Esther D. Mwaikambo, Jackson Mukemba, Salvatory Florence, Tsin W. Yeo, Donald L. Granger, and Nicholas M. Anstey. “The role of alternatively activated (M2) monocytes in limiting NO bioavailability in falciparum malaria.” Nitric Oxide 42 (November 2014): 101–101. https://doi.org/10.1016/j.niox.2014.09.012.

Full Text

Rubach, Matthew P., J Brice Weinberg, Jackson Mukemba, Salvatory Florence, Bert K. Lopansri, Keith Hyland, Alicia D. Volkheimer, et al. “Decreased systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in children with cerebral malaria.” Nitric Oxide 42 (November 2014): 104–5. https://doi.org/10.1016/j.niox.2014.09.021.

Full Text

Friedman, Daphne R., Tiffany Simms, Sallie D. Allgood, Danielle M. Brander, Peter Sportelli, Hari P. Miskin, Swaroop Vakkalanka, Srikant Viswanadha, J Brice Weinberg, and Mark C. Lanasa. “Abstract 4518: The PI3K-δ inhibitor TGR-1202 induces cytotoxicity and inhibits phosphorylation of AKT in 17p deleted and non-17p deleted CLL cells in vitro.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4518.

Full Text

Weinberg, Joe Brice, Tsin W. Yeo, Jackson P. Mukemba, Salvatore M. Florence, Alicia D. Volkheimer, Hao Wang, Youwei Chen, et al. “Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria..” J Infect Dis 210, no. 6 (September 15, 2014): 913–22. https://doi.org/10.1093/infdis/jiu156.

PMID
24620026
Full Text

Mikita, Kei, Kiran Thakur, Nicholas M. Anstey, Kim A. Piera, Carlos A. Pardo, J Brice Weinberg, Jackson Mukemba, et al. “Quantification of Plasmodium falciparum histidine-rich protein-2 in cerebrospinal spinal fluid from cerebral malaria patients..” Am J Trop Med Hyg 91, no. 3 (September 2014): 486–92. https://doi.org/10.4269/ajtmh.14-0210.

PMID
24980497
Full Text

Darcy, Christabelle J., Gabriela Minigo, Kim A. Piera, Joshua S. Davis, Yvette R. McNeil, Youwei Chen, Alicia D. Volkheimer, J Brice Weinberg, Nicholas M. Anstey, and Tonia Woodberry. “Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients..” Crit Care 18, no. 4 (August 1, 2014). https://doi.org/10.1186/cc14003.

PMID
25084831
Full Text

Friedman, Daphne R., Mark C. Lanasa, Patricia H. Davis, Sallie D. Allgood, Karen M. Matta, Danielle M. Brander, Youwei Chen, et al. “Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial and in vitro studies..” Leuk Lymphoma 55, no. 5 (May 2014): 1067–75. https://doi.org/10.3109/10428194.2013.824080.

PMID
23863122
Full Text

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