John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Povsic, Thomas J., Christopher M. O’Connor, Timothy Henry, Andrew Taussig, Dean J. Kereiakes, F David Fortuin, Alan Niederman, et al. “A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction..” American Heart Journal 162, no. 4 (October 2011): 654-662.e1. https://doi.org/10.1016/j.ahj.2011.07.020.

PMID
21982657
Full Text

Povsic, Thomas J., William A. Wargin, John H. Alexander, Joshua Krasnow, Merill Krolick, Mauricio G. Cohen, Roxana Mehran, et al. “Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy..” Eur Heart J 32, no. 19 (October 2011): 2412–19. https://doi.org/10.1093/eurheartj/ehr179.

PMID
21724623
Full Text

Granger, Christopher B., John H. Alexander, John J. V. McMurray, Renato D. Lopes, Elaine M. Hylek, Michael Hanna, Hussein R. Al-Khalidi, et al. “Apixaban versus warfarin in patients with atrial fibrillation..” N Engl J Med 365, no. 11 (September 15, 2011): 981–92. https://doi.org/10.1056/NEJMoa1107039.

PMID
21870978
Full Text

Saito, Shigeru, Ross Prpic, Jeffery J. Popma, John Alexander, Mitchell W. Krucoff, and Mitchell W. ENDEAVOR Japan Investigators. “The clinical evaluation of the Endeavor zotarolimus-eluting coronary stent in Japanese patients with de novo native coronary artery lesions: primary results and 3-year follow-up of the Endeavor Japan study..” Cardiovascular Revascularization Medicine : Including Molecular Interventions 12, no. 5 (September 2011): 273–79. https://doi.org/10.1016/j.carrev.2010.12.007.

PMID
21367669
Full Text

Lobato, Robert L., William D. White, Joseph P. Mathew, Mark F. Newman, Peter K. Smith, Charles B. McCants, John H. Alexander, Mihai V. Podgoreanu, and Mihai V. Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. “Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses..” Circulation 124, no. 11 Suppl (September 2011): S143–48. https://doi.org/10.1161/CIRCULATIONAHA.110.008334.

PMID
21911804
Full Text

Alexander, John H., Renato D. Lopes, Stefan James, Rakhi Kilaru, Yaohua He, Puneet Mohan, Deepak L. Bhatt, et al. “Apixaban with antiplatelet therapy after acute coronary syndrome..” N Engl J Med 365, no. 8 (August 25, 2011): 699–708. https://doi.org/10.1056/NEJMoa1105819.

PMID
21780946
Full Text

Lopes, Renato D., Richard C. Becker, John H. Alexander, Paul W. Armstrong, Robert M. Califf, Mark Y. Chan, Mark Crowther, et al. “Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14-16, 2010, São Paulo, Brazil..” Journal of Thrombosis and Thrombolysis 32, no. 2 (August 2011): 242–66. https://doi.org/10.1007/s11239-011-0592-7.

PMID
21547405
Full Text

Becker, Richard C., Hongqiu Yang, Yuchen Barrett, Puneet Mohan, Jessie Wang, Lars Wallentin, and John H. Alexander. “Chromogenic laboratory assays to measure the factor Xa-inhibiting properties of apixaban--an oral, direct and selective factor Xa inhibitor..” Journal of Thrombosis and Thrombolysis 32, no. 2 (August 2011): 183–87. https://doi.org/10.1007/s11239-011-0591-8.

PMID
21516308
Full Text

Mehta, Rajendra H., T Bruce Ferguson, Renato D. Lopes, Gail E. Hafley, Michael J. Mack, Nicholas T. Kouchoukos, C Michael Gibson, et al. “Saphenous vein grafts with multiple versus single distal targets in patients undergoing coronary artery bypass surgery: one-year graft failure and five-year outcomes from the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV trial..” Circulation 124, no. 3 (July 2011): 280–88. https://doi.org/10.1161/CIRCULATIONAHA.110.991299.

PMID
21709060
Full Text

Pages