John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Cohen, Mauricio G., Drew A. Purdy, Joseph S. Rossi, Liliana R. Grinfeld, Shelley K. Myles, Laura H. Aberle, Adam B. Greenbaum, et al. “First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention..” Circulation 122, no. 6 (August 2010): 614–22. https://doi.org/10.1161/circulationaha.109.927756.

PMID
20660806
Full Text

Lopes, Renato D., David Garcia, Richard C. Becker, Christopher B. Granger, L Kristin Newby, John H. Alexander, E Marc Jolicoeur, et al. “Highlights from the II International Symposium of Thrombosis and Anticoagulation (ISTA), October 22-23, 2009, São Paulo, Brazil..” Journal of Thrombosis and Thrombolysis 29, no. 4 (May 2010): 395–408. https://doi.org/10.1007/s11239-010-0454-8.

PMID
20157840
Full Text

Gharacholou, S Michael, Renato D. Lopes, Jeffrey B. Washam, L Kristin Newby, Stefan K. James, and John H. Alexander. “Antithrombotic therapy in acute coronary syndromes: guidelines translated for the clinician..” Journal of Thrombosis and Thrombolysis 29, no. 4 (May 2010): 516–28. https://doi.org/10.1007/s11239-009-0437-9.

PMID
20091089
Full Text

Frederich, Robert, John H. Alexander, Fred T. Fiedorek, Mark Donovan, Niklas Berglind, Susan Harris, Roland Chen, Robert Wolf, and Kenneth W. Mahaffey. “A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes..” Postgraduate Medicine 122, no. 3 (May 2010): 16–27. https://doi.org/10.3810/pgm.2010.05.2138.

PMID
20463410
Full Text

Rao, Sunil V., Chiara Melloni, Shelley Myles-Dimauro, Samuel Broderick, Andrzej S. Kosinski, Neal S. Kleiman, Vladimír Dzavík, et al. “Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial..” Circulation 121, no. 15 (April 5, 2010): 1713–21. https://doi.org/10.1161/circulationaha.109.913277.

PMID
20368520
Full Text

Krishnan, Anandi, Renato D. Lopes, John H. Alexander, Richard C. Becker, and Larry B. Goldstein. “Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician..” Journal of Thrombosis and Thrombolysis 29, no. 3 (April 2010): 368–77. https://doi.org/10.1007/s11239-010-0439-7.

PMID
20127273
Full Text

Lopes, Renato D., John H. Alexander, Sana M. Al-Khatib, Jack Ansell, Raphael Diaz, J Donald Easton, Bernard J. Gersh, et al. “Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale..” American Heart Journal 159, no. 3 (March 2010): 331–39. https://doi.org/10.1016/j.ahj.2009.07.035.

PMID
20211292
Full Text

Lopes, R. D., J. H. Alexander, and T. B. Ferguson. “The authors reply.” New England Journal of Medicine 361, no. 19 (November 5, 2009): 1909–10.

Scholars@Duke

Al-Khatib, Sana M., Gail Hafley, Robert A. Harrington, Michael J. Mack, Thomas Bruce Ferguson, Eric D. Peterson, Robert M. Califf, Nicholas T. Kouchoukos, and John H. Alexander. “Patterns of management of atrial fibrillation complicating coronary artery bypass grafting: Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT-IV) Trial..” American Heart Journal 158, no. 5 (November 2009): 792–98. https://doi.org/10.1016/j.ahj.2009.09.003.

PMID
19853700
Full Text

Houman Fekrazad, M., Renato D. Lopes, Gregg J. Stashenko, John H. Alexander, and David Garcia. “Treatment of venous thromboembolism: guidelines translated for the clinician..” Journal of Thrombosis and Thrombolysis 28, no. 3 (October 2009): 270–75. https://doi.org/10.1007/s11239-009-0374-7.

PMID
19579012
Full Text

Pages