John Hunter Peel Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 200 Morris Street, Durham, NC 27701
Phone (919) 668-8955
Email address john.h.alexander@duke.edu

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Education and Training

  • Fellow in Cardiology, Medicine, Duke University, 1996 - 2000
  • Medical Resident, Medicine, Children's Hospital Boston, 1993 - 1996
  • M.D., University of Pennsylvania, 1993

Publications

Alexander, J. H., C. B. Granger, Z. Sadowski, P. E. Aylward, H. D. White, T. D. Thompson, R. M. Califf, and E. J. Topol. “Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators..” American Heart Journal 137, no. 5 (May 1999): 799–805. https://doi.org/10.1016/s0002-8703(99)70402-3.

PMID
10220627
Full Text

Sadowski, Z. P., J. H. Alexander, B. Skrabucha, A. Dyduszynski, J. Kuch, E. Nartowicz, G. Swiatecka, D. F. Kong, and C. B. Granger. “Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction..” American Heart Journal 137, no. 5 (May 1999): 792–98. https://doi.org/10.1016/s0002-8703(99)70401-1.

PMID
10220626
Full Text

Eachempati, S. R., C. Young, J. Alexander, F. D. Cirisano, G. C. Rodriguez, and R. L. Reed. “The clinical use of an esophageal Doppler monitor for hemodynamic monitoring in sepsis..” Journal of Clinical Monitoring and Computing 15, no. 3–4 (May 1999): 223–25. https://doi.org/10.1023/a:1009963124127.

PMID
12568174
Full Text

Alexander, J. H., R. A. Harrington, R. H. Tuttle, L. G. Berdan, A. M. Lincoff, J. W. Deckers, M. L. Simoons, et al. “Prior aspirin use predicts worse outcomes in patients with non-ST- elevation acute coronary syndromes.” American Journal of Cardiology 83, no. 8 (April 15, 1999): 1147–51. https://doi.org/10.1016/S0002-9149(99)00049-1.

Full Text

Alexander, J. H., R. A. Harrington, R. H. Tuttle, L. G. Berdan, A. M. Lincoff, J. W. Deckers, M. L. Simoons, et al. “Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy..” The American Journal of Cardiology 83, no. 8 (April 1999): 1147–51. https://doi.org/10.1016/s0002-9149(99)00049-1.

PMID
10215274
Full Text

Alexander, J. H., D. F. Kong, and W. J. Cantor. “Highlights from the 71st American Heart Association Scientific Sessions: November 8 to 11, 1998..” American Heart Journal 137, no. 3 (March 1999): 555–74. https://doi.org/10.1016/s0002-8703(99)70506-5.

PMID
10047641
Full Text

Alexander, J. H., S. Al-Khatib, W. Cantor, A. B. Greenbaum, M. P. Hudson, D. F. Kong, and M. Shah. “Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999.” American Heart Journal 138, no. 1 I (January 1, 1999): 175–90. https://doi.org/10.1016/S0002-8703(99)90000-5.

Full Text

Alexander, J. H., C. B. Granger, Z. Sadowski, P. E. Aylward, H. D. White, T. D. Thompson, R. M. Califf, and E. J. Topol. “Prophylactic lidocaine use in acute myocardial infarction: Incidence and outcomes from two international trials.” American Heart Journal 137, no. 5 (January 1, 1999): 799–805. https://doi.org/10.1016/S0002-8703(99)70402-3.

Full Text

Alexander, J. H., and R. A. Harrington. “Recent antiplatelet drug trials in the acute coronary syndromes. Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT..” Drugs 56, no. 6 (December 1998): 965–76. https://doi.org/10.2165/00003495-199856060-00002.

PMID
9878986
Full Text

Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) trial..” Journal of the American College of Cardiology 32, no. 7 (December 1998): 2003–10.

PMID
9857885
Scholars@Duke

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