Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Suliman, Hagir B., Martha Sue Carraway, Abdelwahid S. Ali, Chrystal M. Reynolds, Karen E. Welty-Wolf, and Claude A. Piantadosi. “The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy..” J Clin Invest 117, no. 12 (December 2007): 3730–41. https://doi.org/10.1172/JCI32967.

PMID
18037988
Full Text

Haden, Douglas W., Hagir B. Suliman, Martha Sue Carraway, Karen E. Welty-Wolf, Abdelwahid S. Ali, Hiroshi Shitara, Hiromichi Yonekawa, and Claude A. Piantadosi. “Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis..” Am J Respir Crit Care Med 176, no. 8 (October 15, 2007): 768–77. https://doi.org/10.1164/rccm.200701-161OC.

PMID
17600279
Full Text

Demchenko, Ivan T., Karen E. Welty-Wolf, Barry W. Allen, and Claude A. Piantadosi. “Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide..” Am J Physiol Lung Cell Mol Physiol 293, no. 1 (July 2007): L229–38. https://doi.org/10.1152/ajplung.00450.2006.

PMID
17416738
Full Text

Reynolds, Crystal M., Hagir B. Suliman, Matha Sue Carraway, John W. Hollingsworth, Kern E. Welty-Wolf, and Claude A. Piantadosi. “Nitric oxide and toll-like receptor 4 are required for cardiac mitochondrial biogenesis after endotoxemia.” In Free Radical Biology and Medicine, 43:S144–S144. ELSEVIER SCIENCE INC, 2007.

Scholars@Duke

Ware, Lorraine B., Eric Camerer, Karen Welty-Wolf, Marcus J. Schultz, and Michael A. Matthay. “Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury..” Am J Physiol Lung Cell Mol Physiol 291, no. 3 (September 2006): L307–11. https://doi.org/10.1152/ajplung.00157.2006.

PMID
16648240
Full Text

Roggli, Victor L., Claude A. Piantadosi, Neil R. MacIntyre, Stephen L. Young, Peter S. Kussin, Mark P. Steele, Martha Sue Carraway, et al. “Physician subsidies for tobacco advertising..” Am J Respir Crit Care Med 173, no. 2 (January 15, 2006). https://doi.org/10.1164/ajrccm.173.2.246.

PMID
16391304
Full Text

Suliman, Hagir B., Martha Sue Carraway, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Carbon monoxide protects against mitochondrial damage in doxorubicin-induced myocardial dysfunction.” In Free Radical Biology and Medicine, 41:S152–S152. ELSEVIER SCIENCE INC, 2006.

Scholars@Duke

Babiker, Abdelwahid Saeed, Hagir B. Suliman, Martha Sue Carraway, Karen E. Welty-Wolf, and Claude A. Piantadosi. “Mitochondrial biogenesis in sepsis: a role for inducible nitric oxide synthase.” In Free Radical Biology and Medicine, 41:S47–S47. ELSEVIER SCIENCE INC, 2006.

Scholars@Duke

Welty-Wolf, Karen E., Martha S. Carraway, Thomas L. Ortel, Andrew J. Ghio, Steven Idell, Jack Egan, Xiaoyun Zhu, Jin-an Jiao, Hing C. Wong, and Claude A. Piantadosi. “Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure..” Am J Physiol Lung Cell Mol Physiol 290, no. 1 (January 2006): L21–31. https://doi.org/10.1152/ajplung.00155.2005.

PMID
16100288
Full Text

Suliman, Hagir B., Karen E. Welty-Wolf, Martha Sue Carraway, David A. Schwartz, John W. Hollingsworth, and Claude A. Piantadosi. “Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli..” Faseb J 19, no. 11 (September 2005): 1531–33. https://doi.org/10.1096/fj.04-3500fje.

PMID
15994412
Full Text

Pages