Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Suliman, Hagir B., Karen E. Welty-Wolf, Marthasue Carraway, Lynn Tatro, and Claude A. Piantadosi. “Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis..” Cardiovasc Res 64, no. 2 (November 1, 2004): 279–88. https://doi.org/10.1016/j.cardiores.2004.07.005.

PMID
15485687
Full Text

Piantadosi, Claude A., Martha Sue Carraway, Karen E. Welty-Wolf, and Hagir B. Suliman. “OXIDATIVE DAMAGE OF MITOCHONDRIA AND MITOCHONDRIAL DNA IN SEPSIS..” In Shock, 21:57–57. Ovid Technologies (Wolters Kluwer Health), 2004. https://doi.org/10.1097/00024382-200403001-00228.

Full Text

Suliman, Hagir B., Martha S. Carraway, Karen E. Welty-Wolf, A Richard Whorton, and Claude A. Piantadosi. “Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1..” J Biol Chem 278, no. 42 (October 17, 2003): 41510–18. https://doi.org/10.1074/jbc.M304719200.

PMID
12902348
Full Text

Carraway, Martha Sue, Karen E. Welty-Wolf, Debra L. Miller, Thomas L. Ortel, Steven Idell, Andrew J. Ghio, Lars C. Petersen, and Claude A. Piantadosi. “Blockade of tissue factor: treatment for organ injury in established sepsis..” Am J Respir Crit Care Med 167, no. 9 (May 1, 2003): 1200–1209. https://doi.org/10.1164/rccm.200204-287OC.

PMID
12714343
Full Text

Miller, D. L., K. E. Welty-Wolf, M. S. Carraway, C. A. Piantadosi, and L. C. Petersen. “Competitive inhibition of Factor VIIa regulates bronchoalveolar lavage cell activation after intratracheal lipopolysaccharide.” In Faseb Journal, 17:C71–C71. FEDERATION AMER SOC EXP BIOL, 2003.

Scholars@Duke

Welty-Wolf, Karen E., Martha S. Carraway, Thomas L. Ortel, and Claude A. Piantadosi. “Coagulation and inflammation in acute lung injury..” Thromb Haemost 88, no. 1 (July 2002): 17–25.

PMID
12152667
Scholars@Duke

Miller, Debra L., Karen Welty-Wolf, Martha Sue Carraway, Mirella Ezban, Andrew Ghio, Hagir Suliman, and Claude A. Piantadosi. “Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide..” Am J Respir Cell Mol Biol 26, no. 6 (June 2002): 650–58. https://doi.org/10.1165/ajrcmb.26.6.4688.

PMID
12034563
Full Text

Welty-Wolf, K. E., M. S. Carraway, D. L. Miller, T. L. Ortel, M. Ezban, A. J. Ghio, S. Idell, and C. A. Piantadosi. “Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons..” Am J Respir Crit Care Med 164, no. 10 Pt 1 (November 15, 2001): 1988–96. https://doi.org/10.1164/ajrccm.164.10.2105027.

PMID
11734456
Full Text

Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury..” Semin Hematol 38, no. 4 Suppl 12 (October 2001): 35–38.

PMID
11735108
Scholars@Duke

Auten, R. L., S. N. Mason, D. T. Tanaka, K. Welty-Wolf, and M. H. Whorton. “Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats.” American Journal of Physiology  Lung Cellular and Molecular Physiology 281, no. 2 25-2 (August 29, 2001).

Scholars@Duke

Pages