Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Welty-Wolf, K. E., M. S. Carraway, Y. C. Huang, S. G. Simonson, S. P. Kantrow, and C. A. Piantadosi. “Bacterial priming increases lung injury in gram-negative sepsis..” American Journal of Respiratory and Critical Care Medicine 158, no. 2 (August 1998): 610–19. https://doi.org/10.1164/ajrccm.158.2.9704064.

PMID
9700142
Full Text

Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons..” American Journal of Respiratory and Critical Care Medicine 157, no. 3 Pt 1 (March 1998): 938–49. https://doi.org/10.1164/ajrccm.157.3.9707129.

PMID
9517615
Full Text

Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. T. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Body to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” In American Journal of Respiratory and Critical Care Medicine, 157:938–49, 1998. https://doi.org/10.1164/ajrccm.157.3.9707129.

Full Text

Simonson, S. G., K. E. Welty-Wolf, Y. C. Huang, D. E. Taylor, S. P. Kantrow, M. S. Carraway, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. I. Physiology and biochemistry..” Journal of Applied Physiology (Bethesda, Md. : 1985) 83, no. 2 (August 1997): 550–58. https://doi.org/10.1152/jappl.1997.83.2.550.

PMID
9262452
Full Text

Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, S. P. Kantrow, M. S. Carraway, L. Y. Chang, J. D. Crapo, and C. A. Piantadosi. “Aerosolized manganese SOD decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis..” Journal of Applied Physiology (Bethesda, Md. : 1985) 83, no. 2 (August 1997): 559–68. https://doi.org/10.1152/jappl.1997.83.2.559.

PMID
9262453
Full Text

Simonson, S. G., Y. C. Huang, P. J. Fracica, K. E. Welty-Wolf, R. E. Moon, S. L. Young, and C. A. Piantadosi. “Changes in the lung after prolonged positive pressure ventilation in normal baboons..” Journal of Critical Care 12, no. 2 (June 1997): 72–82. https://doi.org/10.1016/s0883-9441(97)90004-6.

PMID
9165415
Full Text

Huang, Y. C., P. J. Fracica, S. G. Simonson, J. D. Crapo, S. L. Young, K. E. Welty-Wolf, R. E. Moon, and C. A. Piantadosi. “VA/Q abnormalities during gram negative sepsis..” Respiration Physiology 105, no. 1–2 (August 1996): 109–21. https://doi.org/10.1016/0034-5687(96)00039-4.

PMID
8897657
Full Text

Kanj, S. S., K. Welty-Wolf, J. Madden, V. Tapson, M. A. Baz, R. D. Davis, and J. R. Perfect. “Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature..” Medicine 75, no. 3 (May 1996): 142–56. https://doi.org/10.1097/00005792-199605000-00004.

PMID
8965683
Full Text

Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, P. J. Fracica, J. W. Patterson, and C. A. Piantadosi. “Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis..” Shock (Augusta, Ga.) 5, no. 5 (May 1996): 378–84.

PMID
9156795
Scholars@Duke

Piantadosi, C. A., P. J. Fracica, F. G. Duhaylongsod, Y. C. Huang, K. E. Welty-Wolf, J. D. Crapo, and S. L. Young. “Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis..” Journal of Applied Physiology (Bethesda, Md. : 1985) 78, no. 5 (May 1995): 1823–31. https://doi.org/10.1152/jappl.1995.78.5.1823.

PMID
7649918
Full Text

Pages