Karen Elizabeth Welty-Wolf, MD

Professor of Medicine
Campus mail 0570 Clin Res II, Durham, NC 27710
Phone (919) 684-4938
Email address welty001@mc.duke.edu

Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis. Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis. In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury. Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria. Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Education and Training

  • Fellow in Pulmonary and Critical Care Medicine, Medicine, Duke University, 1990 - 1993
  • Fellow in Infectious Diseases, Medicine, Duke University, 1989 - 1990
  • Medical Resident, Medicine, Duke University, 1986 - 1989
  • M.D., Duke University, 1986

Publications

Huang, Y. C., P. J. Fracica, S. G. Simonson, J. D. Crapo, S. L. Young, K. E. Welty-Wolf, R. E. Moon, and C. A. Piantadosi. “VA/Q abnormalities during gram negative sepsis..” Respir Physiol 105, no. 1–2 (August 1996): 109–21.

PMID
8897657
Scholars@Duke

Kanj, S. S., K. Welty-Wolf, J. Madden, V. Tapson, M. A. Baz, R. D. Davis, and J. R. Perfect. “Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature..” Medicine (Baltimore) 75, no. 3 (May 1996): 142–56. https://doi.org/10.1097/00005792-199605000-00004.

PMID
8965683
Full Text

Welty-Wolf, K. E., S. G. Simonson, Y. C. Huang, P. J. Fracica, J. W. Patterson, and C. A. Piantadosi. “Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis..” Shock 5, no. 5 (May 1996): 378–84.

PMID
9156795
Scholars@Duke

Piantadosi, C. A., P. J. Fracica, F. G. Duhaylongsod, Y. C. Huang, K. E. Welty-Wolf, J. D. Crapo, and S. L. Young. “Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis..” J Appl Physiol (1985) 78, no. 5 (May 1995): 1823–31. https://doi.org/10.1152/jappl.1995.78.5.1823.

PMID
7649918
Full Text

Simonson, S. G., K. Welty-Wolf, Y. T. Huang, J. A. Griebel, M. S. Caplan, P. J. Fracica, and C. A. Piantadosi. “Altered mitochondrial redox responses in gram negative septic shock in primates..” Circ Shock 43, no. 1 (May 1994): 34–43.

PMID
7982271
Scholars@Duke

Kim, J. H., R. A. Cooper, K. E. Welty-Wolf, L. J. Harrell, P. Zwadyk, and M. E. Klotman. “Pseudomonas putrefaciens bacteremia..” Rev Infect Dis 11, no. 1 (January 1989): 97–104.

PMID
2916100
Scholars@Duke

Pages