Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Fanaroff, AC, James, SK, Weisz, G, Prather, K, Anstrom, KJ, Mark, DB, Ben-Yehuda, O, Alexander, KP, Stone, GW, and Ohman, EM. "Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus: RIVER-PCI Trial." Journal of the American College of Cardiology 69, no. 18 (May 2017): 2304-2313.

PMID
28473136
Full Text

Guimarães, PO, Lopes, RD, Stevens, SR, Zimerman, A, Wruck, L, James, SK, Haque, G, Giraldez, RRCV, Alexander, JH, and Alexander, KP. "Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection." Journal of the American Heart Association 6, no. 4 (April 24, 2017).

PMID
28438739
Full Text

Alexander, KP. "Assessing the Utility of Transcatheter Aortic Valve Replacement." JAMA cardiology 2, no. 4 (April 2017): 416-417.

PMID
28146227
Full Text

Sharma, A, and Alexander, KP. "Natriuretic Peptides in Older Patients With Heart Failure: A Look Into the Seeds of Time." Journal of the American Geriatrics Society 65, no. 4 (April 2017): 691-692.

PMID
28176304
Full Text

Otto, CM, Kumbhani, DJ, Alexander, KP, Calhoon, JH, Desai, MY, Kaul, S, Lee, JC, Ruiz, CE, and Vassileva, CM. "2017 ACC Expert Consensus Decision Pathway for Transcatheter Aortic Valve Replacement in the Management of Adults With Aortic Stenosis." Journal of the American College of Cardiology 69, no. 10 (March 2017): 1313-1346.

Full Text

Alexander, KP. "Putting the Acute Coronary Syndrome in Context After 80 Years of Age." Circulation 135, no. 1 (January 2017): 5-6.

PMID
28028059
Full Text

Alexander, KP. "Identifying the frailty phenotype: The evidence for good enough." American heart journal 182 (December 2016): 144-145.

PMID
27914494
Full Text

Rich, MW, Chyun, DA, Skolnick, AH, Alexander, KP, Forman, DE, Kitzman, DW, Maurer, MS, McClurken, JB, Resnick, BM, Shen, WK, and Tirschwell, DL. "Knowledge Gaps in Cardiovascular Care of Older Adults: A Scientific Statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society: Executive Summary." Journal of the American Geriatrics Society 64, no. 11 (November 2016): 2185-2192. (Review)

PMID
27673575
Full Text

Arnold, SV, Grodzinsky, A, Gosch, KL, Kosiborod, M, Jones, PG, Breeding, T, Towheed, A, Beltrame, J, Alexander, KP, and Spertus, JA. "Predictors of Physician Under-Recognition of Angina in Outpatients With Stable Coronary Artery Disease." Circulation. Cardiovascular quality and outcomes 9, no. 5 (September 2016): 554-559.

PMID
27531922
Full Text

Alexander, KP, Rich, MW, Forman, DE, Wenger, NK, Dodson, JA, Alpert, JS, Kirkpatrick, JN, and Maurer, MS. "Top 10 List for the Cardiovascular Care of Older Adults." The American journal of medicine 129, no. 9 (September 2016): 901-902.

PMID
27215904
Full Text

Pages