Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, Karen P., David F. Kong, Aijing Z. Starr, Judith Kramer, Karen Chiswell, Asba Tasneem, and Robert M. Califf. “Portfolio of clinical research in adult cardiovascular disease as reflected in ClinicalTrials.gov..” J Am Heart Assoc 2, no. 5 (September 26, 2013). https://doi.org/10.1161/JAHA.113.000009.

PMID
24072529
Full Text

Bernacki, G. M., and K. P. Alexander. “Aortic stenosis: What long-term care providers need to know.” Annals of Long Term Care 21, no. 9 (September 1, 2013): 22–27.

Scholars@Duke

Bagai, Akshay, Anita Y. Chen, Tracy Y. Wang, Karen P. Alexander, Laine Thomas, E Magnus Ohman, Judith S. Hochman, Eric D. Peterson, and Matthew T. Roe. “Long-term outcomes among older patients with non-ST-segment elevation myocardial infarction complicated by cardiogenic shock..” Am Heart J 166, no. 2 (August 2013): 298–305. https://doi.org/10.1016/j.ahj.2013.05.003.

PMID
23895813
Full Text

Rumsfeld, John S., Karen P. Alexander, David C. Goff, Michelle M. Graham, P Michael Ho, Frederick A. Masoudi, Debra K. Moser, et al. “Cardiovascular health: the importance of measuring patient-reported health status: a scientific statement from the American Heart Association..” Circulation 127, no. 22 (June 4, 2013): 2233–49. https://doi.org/10.1161/CIR.0b013e3182949a2e.

PMID
23648778
Full Text

Amin, Amit P., Alok Bachuwar, Kimberly J. Reid, Adnan K. Chhatriwalla, Adam C. Salisbury, Robert W. Yeh, Mikhail Kosiborod, et al. “Nuisance bleeding with prolonged dual antiplatelet therapy after acute myocardial infarction and its impact on health status..” J Am Coll Cardiol 61, no. 21 (May 28, 2013): 2130–38. https://doi.org/10.1016/j.jacc.2013.02.044.

PMID
23541975
Full Text

Roe, Matthew T., Shuang Li, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, E Magnus Ohman, and Eric D. Peterson. “Long-term outcomes after invasive management for older patients with non-ST-segment elevation myocardial infarction..” Circ Cardiovasc Qual Outcomes 6, no. 3 (May 1, 2013): 323–32. https://doi.org/10.1161/CIRCOUTCOMES.113.000120.

PMID
23652734
Full Text

Subherwal, Sumeet, E Magnus Ohman, Kenneth W. Mahaffey, Sunil V. Rao, John H. Alexander, Tracy Y. Wang, Karen P. Alexander, Vic Hasselblad, and Matthew T. Roe. “Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches..” Am Heart J 165, no. 5 (May 2013): 644-654.e1. https://doi.org/10.1016/j.ahj.2012.11.012.

PMID
23622901
Full Text

Hanna, Elias B., Karen P. Alexander, Anita Y. Chen, Matthew T. Roe, Marjorie Funk, and Jorge F. Saucedo. “Characteristics and in-hospital outcomes of patients with non-ST-segment elevation myocardial infarction undergoing an invasive strategy according to hemoglobin levels..” Am J Cardiol 111, no. 8 (April 15, 2013): 1099–1103. https://doi.org/10.1016/j.amjcard.2012.12.041.

PMID
23453458
Full Text

Pages