Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Subherwal, Sumeet, Deepak L. Bhatt, Shuang Li, Tracy Y. Wang, Laine Thomas, Karen P. Alexander, Manesh R. Patel, et al. “Polyvascular disease and long-term cardiovascular outcomes in older patients with non-ST-segment-elevation myocardial infarction..” Circ Cardiovasc Qual Outcomes 5, no. 4 (July 1, 2012): 541–49. https://doi.org/10.1161/CIRCOUTCOMES.111.964379.

PMID
22715460
Full Text

Holmes, David R., Michael J. Mack, Sanjay Kaul, Arvind Agnihotri, Karen P. Alexander, Steven R. Bailey, John H. Calhoon, et al. “2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement: developed in collaboration with the American Heart Association, American Society of Echocardiography, European Association for Cardio-Thoracic Surgery, Heart Failure Society of America, Mended Hearts, Society of Cardiovascular Anesthesiologists, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance..” Catheter Cardiovasc Interv 79, no. 7 (June 1, 2012): 1023–82. https://doi.org/10.1002/ccd.24351.

PMID
22294439
Full Text

Dodson, John A., Suzanne V. Arnold, Kimberly J. Reid, Thomas M. Gill, Michael W. Rich, Frederick A. Masoudi, John A. Spertus, Harlan M. Krumholz, and Karen P. Alexander. “Physical function and independence 1 year after myocardial infarction: observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry..” Am Heart J 163, no. 5 (May 2012): 790–96. https://doi.org/10.1016/j.ahj.2012.02.024.

PMID
22607856
Full Text

Salisbury, Adam C., Amit P. Amin, Kimberly J. Reid, Tracy Y. Wang, Karen P. Alexander, Paul S. Chan, Frederick A. Masoudi, John A. Spertus, and Mikhail Kosiborod. “Red blood cell indices and development of hospital-acquired anemia during acute myocardial infarction..” Am J Cardiol 109, no. 8 (April 15, 2012): 1104–10. https://doi.org/10.1016/j.amjcard.2011.11.045.

PMID
22264598
Full Text

Fosbol, Emil L., Tracy Y. Wang, Shuang Li, Jonathan P. Piccini, Renato D. Lopes, Bimal Shah, Roger M. Mills, et al. “Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction..” Am Heart J 163, no. 4 (April 2012): 720–28. https://doi.org/10.1016/j.ahj.2012.01.017.

PMID
22520540
Full Text

Holmes, David R., Michael J. Mack, Sanjay Kaul, Arvind Agnihotri, Karen P. Alexander, Steven R. Bailey, John H. Calhoon, et al. “2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement: developed in collaboration with the American Heart Association, American Society of Echocardiography, European Association for Cardio-Thoracic Surgery, Heart Failure Society of America, Mended Hearts, Society of Cardiovascular Anesthesiologists, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance..” Ann Thorac Surg 93, no. 4 (April 2012): 1340–95. https://doi.org/10.1016/j.athoracsur.2012.01.084.

PMID
22300625
Full Text

Holmes, David R., Michael J. Mack, Sanjay Kaul, Arvind Agnihotri, Karen P. Alexander, Steven R. Bailey, John H. Calhoon, et al. “2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement..” J Am Coll Cardiol 59, no. 13 (March 27, 2012): 1200–1254. https://doi.org/10.1016/j.jacc.2012.01.001.

PMID
22300974
Full Text

Subherwal, Sumeet, Eric D. Peterson, Anita Y. Chen, Matthew T. Roe, Jeffrey B. Washam, Brian F. Gage, Richard G. Bach, et al. “Admission international normalized ratio levels, early treatment strategies, and major bleeding risk among non-ST-segment-elevation myocardial infarction patients on home warfarin therapy: insights from the National Cardiovascular Data Registry..” Circulation 125, no. 11 (March 20, 2012): 1414–23. https://doi.org/10.1161/CIRCULATIONAHA.111.059188.

PMID
22319105
Full Text

Dodson, John A., Kimberly J. Reid, Thomas M. Gill, Harlan M. Krumholz, Daniel E. Forman, John A. Spertus, Michael W. Rich, Suzanne V. Arnold, and Karen P. Alexander. “SLOW GAIT AMONG OLDER ADULTS POST-AMI AND RISK FOR HOSPITAL READMISSION.” In Journal of the American College of Cardiology, 59:E1914–E1914. Elsevier BV, 2012. https://doi.org/10.1016/s0735-1097(12)61915-9.

Full Text

Afilalo, Jonathan, Salvatore Mottillo, Mark J. Eisenberg, Karen P. Alexander, Nicolas Noiseux, Louis P. Perrault, Jean-Francois Morin, et al. “Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity..” Circ Cardiovasc Qual Outcomes 5, no. 2 (March 1, 2012): 222–28. https://doi.org/10.1161/CIRCOUTCOMES.111.963157.

PMID
22396586
Full Text

Pages