Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Otto, CM, Kumbhani, DJ, Alexander, KP, Calhoon, JH, Desai, MY, Kaul, S, Lee, JC, Ruiz, CE, and Vassileva, CM. "2017 ACC Expert Consensus Decision Pathway for Transcatheter Aortic Valve Replacement in the Management of Adults With Aortic Stenosis." Journal of the American College of Cardiology 69, no. 10 (March 2017): 1313-1346.

Full Text

Alexander, KP. "Putting the Acute Coronary Syndrome in Context After 80 Years of Age." Circulation 135, no. 1 (January 2017): 5-6.

PMID
28028059
Full Text

Alexander, KP. "Identifying the frailty phenotype: The evidence for good enough." American Heart Journal 182 (December 2016): 144-145.

PMID
27914494
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Rich, MW, Chyun, DA, Skolnick, AH, Alexander, KP, Forman, DE, Kitzman, DW, Maurer, MS, McClurken, JB, Resnick, BM, Shen, WK, and Tirschwell, DL. "Knowledge Gaps in Cardiovascular Care of Older Adults: A Scientific Statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society: Executive Summary." Journal of the American Geriatrics Society 64, no. 11 (November 2016): 2185-2192. (Review)

PMID
27673575
Full Text

Alexander, KP, Rich, MW, Forman, DE, Wenger, NK, Dodson, JA, Alpert, JS, Kirkpatrick, JN, and Maurer, MS. "Top 10 List for the Cardiovascular Care of Older Adults." The American Journal of Medicine 129, no. 9 (September 2016): 901-902.

PMID
27215904
Full Text

Forman, DE, and Alexander, KP. "Frailty: A Vital Sign for Older Adults With Cardiovascular Disease." The Canadian Journal of Cardiology 32, no. 9 (September 2016): 1082-1087. (Review)

PMID
27476987
Full Text

Arnold, SV, Grodzinsky, A, Gosch, KL, Kosiborod, M, Jones, PG, Breeding, T, Towheed, A, Beltrame, J, Alexander, KP, and Spertus, JA. "Predictors of Physician Under-Recognition of Angina in Outpatients With Stable Coronary Artery Disease." Circulation. Cardiovascular Quality and Outcomes 9, no. 5 (September 2016): 554-559.

PMID
27531922
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Armaganijan, LV, Alexander, KP, Huang, Z, Tricoci, P, Held, C, Van de Werf, F, Armstrong, PW, Aylward, PE, White, HD, Moliterno, DJ, Wallentin, L, Chen, E, Harrington, RA, Strony, J, Mahaffey, KW, and Lopes, RD. "Effect of age on efficacy and safety of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome: Insights from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial." American heart journal 178 (August 2016): 176-184.

PMID
27502866
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Wayangankar, SA, Roe, MT, Chen, AY, Gupta, RS, Giugliano, RP, Newby, LK, de Lemos, JA, Alexander, KP, Sanborn, TA, and Saucedo, JF. "Trends in use of anti-thrombotic agents and outcomes in patients with non-ST-segment elevation myocardial infarction (NSTEMI) managed with an invasive strategy." Indian Heart Journal 68, no. 4 (July 2016): 464-472.

PMID
27543467
Full Text

White, HD, Westerhout, CM, Alexander, KP, Roe, MT, Winters, KJ, Cyr, DD, Fox, KA, Prabhakaran, D, Hochman, JS, Armstrong, PW, Ohman, EM, and TRILOGY ACS investigators, . "Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial." European heart journal. Acute cardiovascular care 5, no. 3 (June 2016): 231-242.

PMID
25897147
Full Text

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