Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

White, HD, Westerhout, CM, Alexander, KP, Roe, MT, Winters, KJ, Cyr, DD, Fox, KA, Prabhakaran, D, Hochman, JS, Armstrong, PW, Ohman, EM, and TRILOGY ACS investigators, . "Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial." European heart journal. Acute cardiovascular care 5, no. 3 (June 2016): 231-242.

PMID
25897147
Full Text

Afilalo, J, Kim, S, O'Brien, S, Brennan, JM, Edwards, FH, Mack, MJ, McClurken, JB, Cleveland, JC, Smith, PK, Shahian, DM, and Alexander, KP. "Gait Speed and Operative Mortality in Older Adults Following Cardiac Surgery." JAMA cardiology 1, no. 3 (June 2016): 314-321.

PMID
27438112
Full Text

Rich, MW, Chyun, DA, Skolnick, AH, Alexander, KP, Forman, DE, Kitzman, DW, Maurer, MS, McClurken, JB, Resnick, BM, Shen, WK, Tirschwell, DL, American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council, American College of Cardiology, and and American Geriatrics Society, . "Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society." Circulation 133, no. 21 (May 2016): 2103-2122.

PMID
27067230
Full Text

Alfredsson, J, and Alexander, KP. "Multiple Chronic Conditions in Older Adults with Acute Coronary Syndromes." Clinics in geriatric medicine 32, no. 2 (May 2016): 291-303. (Review)

PMID
27113147
Full Text

Rich, MW, Chyun, DA, Skolnick, AH, Alexander, KP, Forman, DE, Kitzman, DW, Maurer, MS, McClurken, JB, Resnick, BM, Shen, WK, Tirschwell, DL, American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council, , American College of Cardiology, and and American Geriatrics Society, . "Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society." Journal of the American College of Cardiology 67, no. 20 (May 2016): 2419-2440.

PMID
27079335
Full Text

Kragholm, K, Goldstein, SA, Yang, Q, Lopes, RD, Schulte, PJ, Bernacki, GM, White, HD, Mahaffey, KW, Giugliano, RP, Armstrong, PW, Harrington, RA, Tricoci, P, Van de Werf, F, Alexander, JH, Alexander, KP, and Newby, LK. "Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials." CIRCULATION 133, no. 16 (April 19, 2016): 1560-+.

Full Text

Kragholm, K, Goldstein, SA, Yang, Q, Lopes, RD, Schulte, PJ, Bernacki, GM, White, HD, Mahaffey, KW, Giugliano, RP, Armstrong, PW, Harrington, RA, Tricoci, P, Van de Werf, F, Alexander, JH, Alexander, KP, and Newby, LK. "Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment-Elevation Acute Coronary Syndromes Clinical Trials." Circulation 133, no. 16 (April 2016): 1560-1573.

PMID
26957532
Full Text

Alfredsson, J, Stebbins, A, Brennan, JM, Matsouaka, R, Afilalo, J, Peterson, ED, Vemulapalli, S, Rumsfeld, JS, Shahian, D, Mack, MJ, and Alexander, KP. "Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry." Circulation 133, no. 14 (April 2016): 1351-1359.

PMID
26920495
Full Text

Zimerman, A, Lopes, RD, Stebbins, AL, Guimarães, PO, Haque, G, Melloni, C, Trollinger, K, James, SK, Alexander, JH, Tricoci, P, Roe, MT, Ohman, EM, Mahaffey, KW, Held, C, Tinga, B, Pieper, KS, and Alexander, KP. "Pooled analysis of adverse event collection from 4 acute coronary syndrome trials." American heart journal 174 (April 2016): 60-67.

PMID
26995371
Full Text

Dodson, JA, Arnold, SV, Gosch, KL, Gill, TM, Spertus, JA, Krumholz, HM, Rich, MW, Chaudhry, SI, Forman, DE, Masoudi, FA, and Alexander, KP. "Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry." Journal of the American Geriatrics Society 64, no. 3 (March 2016): 596-601.

PMID
26926309
Full Text

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