Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Hochman, Judith S., Harmony R. Reynolds, Sripal Bangalore, Sean M. O’Brien, Karen P. Alexander, Roxy Senior, William E. Boden, et al. “Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial.” Jama Cardiol 4, no. 3 (March 1, 2019): 273–86. https://doi.org/10.1001/jamacardio.2019.0014.

PMID
30810700
Full Text

Fanaroff, Alexander C., Robert Clare, Karen S. Pieper, Kenneth W. Mahaffey, Chiara Melloni, Jennifer B. Green, John H. Alexander, et al. “Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials.” Circulation 139, no. 7 (February 12, 2019): 863–73. https://doi.org/10.1161/CIRCULATIONAHA.118.037202.

PMID
30586739
Full Text

Alexander, Karen P., Marc A. Brouwer, Hillary Mulder, Dragos Vinereanu, Renato D. Lopes, Marco Proietti, Sana M. Al-Khatib, et al. “Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial.” Am Heart J 208 (February 2019): 123–31. https://doi.org/10.1016/j.ahj.2018.09.017.

PMID
30579505
Full Text

Afilalo, Jonathan, Abhinav Sharma, Shuaiqi Zhang, J Matthew Brennan, Fred H. Edwards, Michael J. Mack, James B. McClurken, et al. “Gait Speed and 1-Year Mortality Following Cardiac Surgery: A Landmark Analysis From the Society of Thoracic Surgeons Adult Cardiac Surgery Database.” J Am Heart Assoc 7, no. 23 (December 4, 2018): e010139. https://doi.org/10.1161/JAHA.118.010139.

PMID
30571598
Full Text

Schwartz, Gregory G., P Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Jay M. Edelberg, et al. “Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.” N Engl J Med 379, no. 22 (November 29, 2018): 2097–2107. https://doi.org/10.1056/NEJMoa1801174.

PMID
30403574
Full Text

Dodson, John A., Judith S. Hochman, Matthew T. Roe, Anita Y. Chen, Sarwat I. Chaudhry, Stuart Katz, Hua Zhong, et al. “The Association of Frailty With In-Hospital Bleeding Among Older Adults With Acute Myocardial Infarction: Insights From the ACTION Registry.” Jacc Cardiovasc Interv 11, no. 22 (November 26, 2018): 2287–96. https://doi.org/10.1016/j.jcin.2018.08.028.

PMID
30466828
Full Text

Bangalore, Sripal, David J. Maron, Jerome L. Fleg, Sean M. O’Brien, Charles A. Herzog, Gregg W. Stone, Daniel B. Mark, et al. “International Study of Comparative Health Effectiveness with Medical and Invasive Approaches-Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design.” Am Heart J 205 (November 2018): 42–52. https://doi.org/10.1016/j.ahj.2018.07.023.

PMID
30172098
Full Text

Ekerstad, Niklas, Staffan Pettersson, Karen Alexander, David Andersson, Sofia Eriksson, Magnus Janzon, Marcus Lindenberger, Eva Swahn, and Joakim Alfredsson. “Frailty as an instrument for evaluation of elderly patients with non-ST-segment elevation myocardial infarction: A follow-up after more than 5 years.” Eur J Prev Cardiol 25, no. 17 (November 2018): 1813–21. https://doi.org/10.1177/2047487318799438.

PMID
30247067
Full Text

Hernandez, Adrian F., Jennifer B. Green, Salim Janmohamed, Ralph B. D’Agostino, Christopher B. Granger, Nigel P. Jones, Lawrence A. Leiter, et al. “Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.” Lancet 392, no. 10157 (October 27, 2018): 1519–29. https://doi.org/10.1016/S0140-6736(18)32261-X.

PMID
30291013
Full Text

Krishnaswami, Ashok, Dae Hyun Kim, Charles E. McCulloch, Daniel E. Forman, Mathew S. Maurer, Karen P. Alexander, and Michael W. Rich. “Individual and Joint Effects of Pulse Pressure and Blood Pressure Treatment Intensity on Serious Adverse Events in the SPRINT Trial.” Am J Med 131, no. 10 (October 2018): 1220-1227.e1. https://doi.org/10.1016/j.amjmed.2018.05.027.

PMID
29940151
Full Text

Pages