Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Wang, Tracy Y., Lan Xiao, Karen P. Alexander, Sunil V. Rao, Mikhail N. Kosiborod, John S. Rumsfeld, John A. Spertus, and Eric D. Peterson. “Antiplatelet therapy use after discharge among acute myocardial infarction patients with in-hospital bleeding..” Circulation 118, no. 21 (November 18, 2008): 2139–45. https://doi.org/10.1161/CIRCULATIONAHA.108.787143.

PMID
18981304
Full Text

Alexander, Karen P., Patricia A. Cowper, Judith A. Kempf, Barbara L. Lytle, and Eric D. Peterson. “Profile of chronic and recurrent angina pectoris in a referral population..” Am J Cardiol 102, no. 10 (November 15, 2008): 1301–6. https://doi.org/10.1016/j.amjcard.2008.07.006.

PMID
18993145
Full Text

Patel, Uptal D., Joshua Grab, Mikhail Kosiborod, Barbara Lytle, Eric D. Peterson, and Karen P. Alexander. “Impact of anemia on physical function and survival among patients with coronary artery disease..” Clin Cardiol 31, no. 11 (November 2008): 546–50. https://doi.org/10.1002/clc.20283.

PMID
19006118
Full Text

Fox, Caroline S., Paul Muntner, Anita Y. Chen, Karen P. Alexander, Matthew T. Roe, Jorge F. Saucedo, and Stephen D. Wiviott. “Short-Term Outcomes of STEMI and NSTEMI in Patients with Chronic Kidney Disease: A Report from the National Cardiovascular Data ACTION Registry.” Circulation 118, no. 18 (October 28, 2008): S966–S966.

Scholars@Duke

Cavender, Matthew A., Karen P. Alexander, Samuel Broderick, Linda K. Shaw, Judith Kempf, and E Magnus Ohman. “Long-Term Morbidity and Mortality among Patients with Angina and Multivessel Coronary Artery Disease in the Duke Cardiovascular Databank.” Circulation 118, no. 18 (October 28, 2008): S853–S853.

Scholars@Duke

Reeves, Gordon R., Tracy Y. Wang, Kimberly J. Reid, Karen P. Alexander, Carole Decker, Homaa Ahmad, John A. Spertus, and Eric D. Peterson. “Dissociation between hospital performance of the smoking cessation counseling quality metric and cessation outcomes after myocardial infarction..” Arch Intern Med 168, no. 19 (October 27, 2008): 2111–17. https://doi.org/10.1001/archinte.168.19.2111.

PMID
18955640
Full Text

Roe, Matthew T., Fang-Shu Ou, Karen P. Alexander, Laura Kristin Newby, Joanne M. Foody, W Brian Gibler, William E. Boden, Erik Magnus Ohman, Sidney C. Smith, and Eric D. Peterson. “Patterns and prognostic implications of low high-density lipoprotein levels in patients with non-ST-segment elevation acute coronary syndromes..” Eur Heart J 29, no. 20 (October 2008): 2480–88. https://doi.org/10.1093/eurheartj/ehn364.

PMID
18716006
Full Text

Singh, Mandeep, Karen Alexander, Veronique L. Roger, Charanjit S. Rihal, Heather E. Whitson, Amir Lerman, Arschad Jahangir, and K Sreekumaran Nair. “Frailty and its potential relevance to cardiovascular care..” Mayo Clin Proc 83, no. 10 (October 2008): 1146–53. https://doi.org/10.4065/83.10.1146.

PMID
18828975
Full Text

Wang, Tracy Y., Anita Y. Chen, Karen P. Alexander, E Magnus Ohman, W Brian Gibler, Eric D. Peterson, and Matthew T. Roe. “Excess heparin dosing among fibrinolytic-treated patients with ST-segment elevation myocardial infarction..” Am J Med 121, no. 9 (September 2008): 805–10. https://doi.org/10.1016/j.amjmed.2008.04.023.

PMID
18724971
Full Text

Dunlay, Shannon M., Karen P. Alexander, Chiara Melloni, Jennifer L. Kraschnewski, Li Liang, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, and Eric D. Peterson. “Medical records and quality of care in acute coronary syndromes: results from CRUSADE..” Arch Intern Med 168, no. 15 (August 11, 2008): 1692–98. https://doi.org/10.1001/archinte.168.15.1692.

PMID
18695085
Full Text

Pages