Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Kraschnewski, Jennifer L., Li Liang, Shannon M. Dunlay, Chiara Melloni, Deborah B. Diercks, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, Eric D. Peterson, and Karen P. Alexander. “Age, presentation, and emergency department diagnosis of acute coronary syndromes: Results from CRUSADE.” Circulation 115, no. 21 (May 29, 2007): E584–E584.

Scholars@Duke

Alexander, Karen P., L Kristin Newby, Paul W. Armstrong, Christopher P. Cannon, W Brian Gibler, Michael W. Rich, Frans Van de Werf, et al. “Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology..” Circulation 115, no. 19 (May 15, 2007): 2570–89. https://doi.org/10.1161/CIRCULATIONAHA.107.182616.

PMID
17502591
Full Text

Alexander, Karen P., L Kristin Newby, Christopher P. Cannon, Paul W. Armstrong, W Brian Gibler, Michael W. Rich, Frans Van de Werf, et al. “Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology..” Circulation 115, no. 19 (May 15, 2007): 2549–69. https://doi.org/10.1161/CIRCULATIONAHA.107.182615.

PMID
17502590
Full Text

Skolnick, Adam H., Karen P. Alexander, Anita Y. Chen, Matthew T. Roe, Charles V. Pollack, E Magnus Ohman, John S. Rumsfeld, W Brian Gibler, Eric D. Peterson, and David J. Cohen. “ or =90 years with acute coronary syndromes: results from the CRUSADE Initiative..” J Am Coll Cardiol 49, no. 17 (May 1, 2007): 1790–97. https://doi.org/10.1016/j.jacc.2007.01.066.

PMID
17466230
Full Text

Frazier, Camille G., Karen P. Alexander, L Kristin Newby, Susan Anderson, Erik Iverson, Milton Packer, Jay Cohn, Sidney Goldstein, and Pamela S. Douglas. “Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials..” J Am Coll Cardiol 49, no. 13 (April 3, 2007): 1450–58. https://doi.org/10.1016/j.jacc.2006.11.041.

PMID
17397674
Full Text

Wang, Tracy Y., Anita Y. Chen, Matthew T. Roe, Karen P. Alexander, L Kristin Newby, Sidney C. Smith, Sripal Bangalore, W Brian Gibler, E Magnus Ohman, and Eric D. Peterson. “Increased bleeding risk among Asians with non-ST-segment elevation acute coronary syndromes: Insights from the CRUSADE quality improvement initiative.” In Journal of the American College of Cardiology, 49:208A-208A. ELSEVIER SCIENCE INC, 2007.

Scholars@Duke

Alexander, Karen P., Patricia A. Cowper, Barbara L. Lylte, Judith A. Kempf, and Eric D. Peterson. “Predictors of persistent angina among coronary disease patients.” In Journal of the American College of Cardiology, 49:232A-232A. ELSEVIER SCIENCE INC, 2007.

Scholars@Duke

Roe, Matthew T., Karen P. Alexander, Fang-Shou Ou, L Kristin Newby, W Brian Gibler, Charles V. Pollack, E Magnus Ohman, Sidney C. Smith, and Eric D. Peterson. “Patterns of HDL levels in patients with non-ST-segment elevation acute coronary syndromes and association with clinical outcomes.” In Journal of the American College of Cardiology, 49:366A-366A. ELSEVIER SCIENCE INC, 2007.

Scholars@Duke

Alexander, Karen P., Patricia A. Cowper, Barbara L. Lytle, Judith A. Kempf, and Eric D. Peterson. “Less is better, none is best: Angina and health related quality of life.” In Journal of the American College of Cardiology, 49:229A-229A. ELSEVIER SCIENCE INC, 2007.

Scholars@Duke

Ali, Robin, and Karen P. Alexander. “Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence..” Am J Geriatr Pharmacother 5, no. 1 (March 2007): 52–63.

PMID
17608248
Scholars@Duke

Pages