Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, KP, Melloni, C, Pappas, A, Newby, LK, LaPointe, NMA, Ohman, EM, Gibler, WB, Roe, MT, and Peterson, ED. "Potency of statins track with intensity of overall secondary prevention." 9th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. Baltimore, MD. April 30, 2008 - May 2, 2008.: LIPPINCOTT WILLIAMS & WILKINS, May 27, 2008.

Scholars@Duke

Melloni, C, Alexander, KP, Ou, F-S, LaPointe, NMA, Roe, MT, and Peterson, ED. "Factors associated with patient reported self-discontinuation of prescribed medicine after non-ST-segment elevation acute coronary syndromes." 9th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. Baltimore, MD. April 30, 2008 - May 2, 2008.: LIPPINCOTT WILLIAMS & WILKINS, May 27, 2008.

Scholars@Duke

Ho, PM, Eng, MH, Rumsfeld, JS, Spertus, JA, Peterson, PN, Jones, PG, Peterson, ED, Alexander, KP, Havranek, EP, Krumholz, HM, and Masoudi, FA. "The influence of age on health status outcomes after acute myocardial infarction." American Heart Journal 155, no. 5 (May 2008): 855-861.

PMID
18440332
Full Text

Subherwal, S, Bach, RG, Chen, AY, Gage, BF, Rao, SV, Wang, TY, Gibler, WB, Ohman, EM, Peterson, ED, Roe, MT, and Alexander, KP. "The CRUSADE bleeding score to assess baseline risk of major bleeding in non-ST-segment elevation myocardial infarction." 57th Annual Scientific Session of the American-College-of-Cardiology. Chicago, IL. March 29, 2008 - April 1, 2008.: ELSEVIER SCIENCE INC, March 11, 2008.

Scholars@Duke

Alexander, KP, Bach, RG, Chen, AY, Subherwal, S, Gage, BF, Rao, SV, Gibler, WB, Pollack, CV, Ohman, EM, Roe, MT, and Peterson, ED. "Bleeding and ischemic events run parallel in NSTEMI patients." 57th Annual Scientific Session of the American-College-of-Cardiology. Chicago, IL. March 29, 2008 - April 1, 2008.: ELSEVIER SCIENCE INC, March 11, 2008.

Scholars@Duke

Wang, TY, Chen, AY, Peterson, ED, Alexander, KP, Ohman, EM, Gibler, WB, and Roe, MT. "Incidence and bleeding outcomes of excess unfractionated heparin dosing among patients with ST-Segment elevation myocardial infarction undergoing fibrinolysis." 57th Annual Scientific Session of the American-College-of-Cardiology. Chicago, IL. March 29, 2008 - April 1, 2008.: ELSEVIER SCIENCE INC, March 11, 2008.

Scholars@Duke

Melloni, C, Peterson, ED, Chen, AY, Szczech, LA, Newby, LK, Harrington, RA, Gibler, WB, Ohman, EM, Spinler, SA, Roe, MT, and Alexander, KP. "Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes." Journal of the American College of Cardiology 51, no. 10 (March 2008): 991-996.

PMID
18325437
Full Text

Melloni, C, Alexander, KP, Milford-Beland, S, Newby, LK, Szczech, LA, Pollack, CV, Kirk, JD, Christenson, RH, Harrington, RA, Gibler, WB, Ohman, EM, Peterson, ED, Roe, MT, and Crusade Investigators, . "Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease." Clinical Cardiology 31, no. 3 (March 2008): 125-129.

PMID
18383049
Full Text

Cohen, M, Alexander, KP, and Rao, SV. "Bleeding after antithrombotic therapy in patients with acute ischemic heart disease." Journal of Thrombosis and Thrombolysis 26, no. 3 (2008): 175-182.

PMID
18080799
Full Text

Dove, JT, Zieman, SJ, Alexander, K, and Miller, A. "President's Page: Cardiovascular Care in Older Adults: The ACC and SGC Partnership Builds New Curriculum." Journal of the American College of Cardiology 51, no. 6 (2008): 672-673.

PMID
18261688
Full Text

Pages