Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Melloni, Chiara, Karen P. Alexander, Sarah Milford-Beland, L Kristin Newby, Lynda A. Szczech, Charles V. Pollack, J Douglas Kirk, et al. “Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease..” Clinical Cardiology 31, no. 3 (March 2008): 125–29. https://doi.org/10.1002/clc.20210.

PMID
18383049
Full Text

Dove, James T., Susan J. Zieman, Karen Alexander, and Andrew Miller. “President's page: Cardiovascular care in older adults: the ACC and SGC partnership builds new curriculum..” Journal of the American College of Cardiology 51, no. 6 (February 2008): 672–73. https://doi.org/10.1016/j.jacc.2008.01.002.

PMID
18261688
Full Text

Alexander, Karen P., Anita Y. Chen, Matthew T. Roe, L Kristin Newby, Brian Gibler, E Magnus Ohman, Charles V. Pollack, and Eric D. Peterson. “Decline in GP 2b3a inhibitor overdosing with site-specific feedback in CRUSADE.” In Circulation, 116:798–99. LIPPINCOTT WILLIAMS & WILKINS, 2007.

Scholars@Duke

Melloni, Chiara, Karen P. Alexander, Anita Y. Chen, Matthew T. Roe, L Kristin Newby, Magnus Ohman, W Brian Gibler, Sidney C. Smith, Charles V. Pollak, and Eric D. Peterson. “Unfractionated heparin dosing and major bleeding in non-ST-segment elevation acute coronary syndromes.” Circulation 116, no. 16 (October 16, 2007): 383–383.

Scholars@Duke

Wong, Cheuk-Kit, L Kristin Newby, Manju V. Bhapker, Phil E. Aylward, Matthias Pfisterer, Karen P. Alexander, Paul W. Armstrong, et al. “Use of evidence-based medicine for acute coronary syndromes in the elderly and very elderly: insights from the Sibrafiban vs aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes trials..” American Heart Journal 154, no. 2 (August 2007): 313–21. https://doi.org/10.1016/j.ahj.2007.04.031.

PMID
17643582
Full Text

Wang, Tracy Y., Anita Y. Chen, Matthew T. Roe, Karen P. Alexander, L Kristin Newby, Sidney C. Smith, Sripal Bangalore, W Brian Gibler, E Magnus Ohman, and Eric D. Peterson. “Comparison of baseline characteristics, treatment patterns, and in-hospital outcomes of Asian versus non-Asian white Americans with non-ST-segment elevation acute coronary syndromes from the CRUSADE quality improvement initiative..” The American Journal of Cardiology 100, no. 3 (August 2007): 391–96. https://doi.org/10.1016/j.amjcard.2007.03.035.

PMID
17659915
Full Text

LaPointe, Nancy M Allen, Anita Y. Chen, Karen P. Alexander, Matthew T. Roe, Charles V. Pollack, Barbara L. Lytle, Magnus E. Ohman, Brian W. Gibler, and Eric D. Peterson. “Enoxaparin dosing and associated risk of in-hospital bleeding and death in patients with non ST-segment elevation acute coronary syndromes..” Archives of Internal Medicine 167, no. 14 (July 2007): 1539–44. https://doi.org/10.1001/archinte.167.14.1539.

PMID
17646609
Full Text

Wang, Tracy Y., Anita Y. Chen, Magnus Ohman, Karen P. Alexander, Charles V. Pollack, Sidney C. Smith, W Brian Gibler, Matthew T. Roe, and Eric D. Peterson. “Contemporary patterns of reperfusion for elderly patients with ST-segment elevation myocardial infarction.” In Circulation, 115:E582–E582. LIPPINCOTT WILLIAMS & WILKINS, 2007.

Scholars@Duke

Kraschnewski, Jennifer L., Li Liang, Shannon M. Dunlay, Chiara Melloni, Deborah B. Diercks, W Brian Gibler, Matthew T. Roe, E Magnus Ohman, Eric D. Peterson, and Karen P. Alexander. “Age, presentation, and emergency department diagnosis of acute coronary syndromes: Results from CRUSADE.” Circulation 115, no. 21 (May 29, 2007): E584–E584.

Scholars@Duke

Pages