Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Ali, Robin, and Karen P. Alexander. “Statins for the primary prevention of cardiovascular events in older adults: a review of the evidence..” Am J Geriatr Pharmacother 5, no. 1 (March 2007): 52–63.

PMID
17608248
Scholars@Duke

Purser, Jama L., Maragatha N. Kuchibhatla, Gerda G. Fillenbaum, Tina Harding, Eric D. Peterson, and Karen P. Alexander. “Identifying frailty in hospitalized older adults with significant coronary artery disease..” J Am Geriatr Soc 54, no. 11 (November 2006): 1674–81. https://doi.org/10.1111/j.1532-5415.2006.00914.x.

PMID
17087693
Full Text

Alexander, Karen P., Anita Y. Chen, L Kristin Newby, Nancy M Allen LaPointe, E Magnus Ohman, Matthew T. Roe, William E. Boden, and Eric D. Peterson. “Blood transfusion and mortality among patients with non-ST-segment elevation acute coronary syndromes: Results from CRUSADE.” Circulation 114, no. 18 (October 31, 2006): 701–701.

Scholars@Duke

Frazier, Camille G., Karen P. Alexander, L Kristin Newby, Milton Packer, Jay Cohn, Sidney Goldstein, Ake Hjalmarson, Susan Anderson, Erik Iverson, and Pamela S. Douglas. “Sex differences in heart failure with systolic dysfunction: A pooled analysis of five randomized control trials.” Circulation 114, no. 18 (October 31, 2006): 573–573.

Scholars@Duke

Mellori, Chiara, Eric D. Peterson, Anita Y. Chen, Lynda A. Szczech, L Kristin Newby, Robert A. Harrington, W Brian Gibler, et al. “Importance of glomerular filtration rate formula for determining chronic kidney disease and clinical care in patients with acute coronary syndromes.” Circulation 114, no. 18 (October 31, 2006): 406–406.

Scholars@Duke

Alexander, Karen P., E Magnus Ohman, Michel E. Bertrand, Frederic Feit, Charles V. Pollack, James Hoekstra, Bernard J. Gersh, Harvey D. White, and Gregg W. Stone. “Outcomes in elderly patients undergoing PCI treated with bivalirudin monotherapy versus glycoprotein IIb/IIIa inhibitors with hepaiin or LMWH: Results from the randomized ACUITY trial.” In American Journal of Cardiology, 98:18M-18M. EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2006.

Scholars@Duke

Alexander, Karen P., Anita Y. Chen, L Kristin Newby, Janice B. Schwartz, Rita F. Redberg, Judith S. Hochman, Matthew T. Roe, et al. “Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative..” Circulation 114, no. 13 (September 26, 2006): 1380–87. https://doi.org/10.1161/CIRCULATIONAHA.106.620815.

PMID
16982940
Full Text

Kraschnewski, J. L., K. P. Alexander, and E. D. Peterson. “Coronary artery disease in later life.” Generations 30, no. 3 (September 1, 2006): 17–23.

Scholars@Duke

Mehta, R. H., E. D. Peterson, L. Liang, K. P. Alexander, W. B. Gibler, E. M. Ohman, C. V. Pollack, and M. T. Roe. “Contraindications to cardiac catheterization in non-ST-elevation acute coronary syndromes: Insights from the CRUSADE national quality improvement initiative.” In European Heart Journal, 27:183–183. OXFORD UNIV PRESS, 2006.

Scholars@Duke

Alexander, Karen P., Laura Kristin Newby, Manju V. Bhapkar, Harvey D. White, Judith S. Hochman, Matthias E. Pfisterer, David J. Moliterno, et al. “International variation in invasive care of the elderly with acute coronary syndromes..” Eur Heart J 27, no. 13 (July 2006): 1558–64. https://doi.org/10.1093/eurheartj/ehl067.

PMID
16760200
Full Text

Pages