Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Frazier, CG, Alexander, KP, Newby, LK, Packer, M, Cohn, J, Goldstein, S, Hjalmarson, A, Anderson, S, Iverson, E, and Douglas, PS. "Sex differences in heart failure with systolic dysfunction: A pooled analysis of five randomized control trials." CIRCULATION 114, no. 18 (October 31, 2006): 573-573.

Scholars@Duke

Mellori, C, Peterson, ED, Chen, AY, Szczech, LA, Newby, LK, Harrington, RA, Gibler, WB, Ohman, WM, Spinler, SA, Roe, MT, and Alexander, KP. "Importance of glomerular filtration rate formula for determining chronic kidney disease and clinical care in patients with acute coronary syndromes." Circulation 114, no. 18 (October 31, 2006): 406-406.

Scholars@Duke

Alexander, KP, Ohman, EM, Bertrand, ME, Feit, F, Jr, PCV, Hoekstra, J, Gersh, BJ, White, HD, and Stone, GW. "Outcomes in elderly patients undergoing PCI treated with bivalirudin monotherapy versus glycoprotein IIb/IIIa inhibitors with hepaiin or LMWH: Results from the randomized ACUITY trial." October 22, 2006.

Scholars@Duke

Alexander, KP, Chen, AY, Newby, LK, Schwartz, JB, Redberg, RF, Hochman, JS, Roe, MT, Gibler, WB, Ohman, EM, Peterson, ED, and CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) Investigators, . "Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative." Circulation 114, no. 13 (September 18, 2006): 1380-1387.

PMID
16982940
Full Text

Kraschnewski, JL, Alexander, KP, and Peterson, ED. "Coronary artery disease in later life." Generations 30, no. 3 (September 1, 2006): 17-23.

Scholars@Duke

Mehta, RH, Peterson, ED, Liang, L, Alexander, KP, Gibler, WB, Ohman, EM, Pollack, CV, Roe, MT, and Investigators, TCRUSADE. "Contraindications to cardiac catheterization in non-ST-elevation acute coronary syndromes: Insights from the CRUSADE national quality improvement initiative." August 2006.

Scholars@Duke

Alexander, KP, Newby, LK, Bhapkar, MV, White, HD, Hochman, JS, Pfisterer, ME, Moliterno, DJ, Peterson, ED, Van de Werf, F, Armstrong, PW, Califf, RM, and Symphony and 2nd Symphony Investigators, . "International variation in invasive care of the elderly with acute coronary syndromes." European Heart Journal 27, no. 13 (July 2006): 1558-1564.

PMID
16760200
Full Text

Swaminathan, RV, and Alexander, KP. "Pulse pressure and vascular risk in the elderly: associations and clinical implications." Am J Geriatr Cardiol 15, no. 4 (July 2006): 226-232. (Review)

PMID
16849888
Scholars@Duke

Gharacholou, SM, and Alexander, KP. "Issues with care in the elderly patient presenting with acute ischemia." Curr Heart Fail Rep 3, no. 2 (June 2006): 51-56. (Review)

PMID
16933401
Scholars@Duke

Dunlay, SM, Liang, L, Melloni, C, Kraschnewski, JL, Alexander, KP, Gibler, WB, Roe, MT, Ohman, EM, and Peterson, ED. "Quality of medical record documentation in an acute coronary syndrome population: Results from CRUSADE." 7th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. Washington, DC. May 7, 2006 - May 9, 2006.: LIPPINCOTT WILLIAMS & WILKINS, May 30, 2006.

Scholars@Duke

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