Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Yang, Xin, Karen P. Alexander, Anita Y. Chen, Matthew T. Roe, Ralph G. Brindis, Sunil V. Rao, W Brian Gibler, E Magnus Ohman, Eric D. Peterson, and Eric D. CRUSADE Investigators. “The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative..” J Am Coll Cardiol 46, no. 8 (October 18, 2005): 1490–95. https://doi.org/10.1016/j.jacc.2005.06.072.

PMID
16226173
Full Text

Alexander, Karen P., Matthew T. Roe, Anita Y. Chen, Barbara L. Lytle, Charles V. Pollack, Joanne M. Foody, William E. Boden, et al. “Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from the CRUSADE National Quality Improvement Initiative..” J Am Coll Cardiol 46, no. 8 (October 18, 2005): 1479–87. https://doi.org/10.1016/j.jacc.2005.05.084.

PMID
16226171
Full Text

Spinler, S., K. P. Alexander, A. Y. Chen, M. T. Roe, W. B. Gibler, M. Ohman, and E. D. Peterson. “Predictors of excess dosing of injectable antithrombotics in patients with non-ST-segment elevation acute coronary syndromes..” In Pharmacotherapy, 25:1437–38. PHARMACOTHERAPY PUBLICATIONS INC, 2005.

Scholars@Duke

Gharacholou, S Michael, and Karen P. Alexander. “Issues with care in the elderly patient presenting with acute ischemia..” Curr Cardiol Rep 7, no. 4 (July 2005): 270–75.

PMID
15987624
Scholars@Duke

Alexander, K. P., A. Y. Chen, M. T Roe, L. K. Newby, W. B. Gibler, E. M. Ohman, and E. D. Peterson. “Antiplatelet and antithrombin dose variation in patients with non-ST-segment elevation acute coronary syndromes.” In Circulation, 111:E312–13. LIPPINCOTT WILLIAMS & WILKINS, 2005.

Scholars@Duke

Alexander, K. P., J. L. Sun, T. Harding, and B. Lee. “Who is right and what matters? Frailty in patients with cardiovascular disease.” In Circulation, 111:E339–40. LIPPINCOTT WILLIAMS & WILKINS, 2005.

Scholars@Duke

DeLong, E. R., B. L. Lytle, P. A. Cowper, K. P. Alexander, E. D. Peterson, and D. B. Mark. “Research, managed care, and patient privacy: Challenges to successful collaboration.” Journal of Clinical Outcomes Management 12, no. 3 (March 1, 2005): 151–56.

Scholars@Duke

Mehta, Rajendra H., Christopher B. Granger, Karen P. Alexander, Eduardo Bossone, Harvey D. White, and Michael H. Sketch. “Reperfusion strategies for acute myocardial infarction in the elderly: benefits and risks..” J Am Coll Cardiol 45, no. 4 (February 15, 2005): 471–78. https://doi.org/10.1016/j.jacc.2004.10.065.

PMID
15708688
Full Text

Mehta, S. R., S. Yusuf, R. Díaz, J. Zhu, P. Pais, D. Xavier, E. Paolasso, et al. “Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: The CREATE-ECLA randomized controlled trial.” Journal of the American Medical Association 293, no. 4 (2005): 437–46. https://doi.org/10.1001/jama.293.4.437.

Full Text

Heitner, John F., Igor Klem, Karen Alexander, Louise Thomson, Trip J. Meine, Manesh R. Patel, Salman A. Haq, Dipan J. Shah, and Raymond J. Kim. “The case of the disappearing myxoma..” J Cardiovasc Magn Reson 7, no. 5 (2005): 841–43. https://doi.org/10.1080/10976640500288156.

PMID
16353446
Full Text

Pages