Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Rich, Michael W., Deborah A. Chyun, Adam H. Skolnick, Karen P. Alexander, Daniel E. Forman, Dalane W. Kitzman, Mathew S. Maurer, et al. “Knowledge Gaps in Cardiovascular Care of Older Adults: A Scientific Statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society: Executive Summary.” J Am Geriatr Soc 64, no. 11 (November 2016): 2185–92. https://doi.org/10.1111/jgs.14576.

PMID
27673575
Full Text

Alexander, Karen P., Michael W. Rich, Daniel E. Forman, Nanette K. Wenger, John A. Dodson, Joseph S. Alpert, James N. Kirkpatrick, and Mathew S. Maurer. “Top 10 List for the Cardiovascular Care of Older Adults.” Am J Med 129, no. 9 (September 2016): 901–2. https://doi.org/10.1016/j.amjmed.2016.04.031.

PMID
27215904
Full Text

Arnold, Suzanne V., Anna Grodzinsky, Kensey L. Gosch, Mikhail Kosiborod, Philip G. Jones, Tracie Breeding, Arooge Towheed, John Beltrame, Karen P. Alexander, and John A. Spertus. “Predictors of Physician Under-Recognition of Angina in Outpatients With Stable Coronary Artery Disease.” Circ Cardiovasc Qual Outcomes 9, no. 5 (September 2016): 554–59. https://doi.org/10.1161/CIRCOUTCOMES.116.002781.

PMID
27531922
Full Text

Armaganijan, Luciana V., Karen P. Alexander, Zhen Huang, Pierluigi Tricoci, Claes Held, Frans Van de Werf, Paul W. Armstrong, et al. “Effect of age on efficacy and safety of vorapaxar in patients with non-ST-segment elevation acute coronary syndrome: Insights from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial.” Am Heart J 178 (August 2016): 176–84. https://doi.org/10.1016/j.ahj.2016.05.012.

PMID
27502866
Full Text

Wayangankar, S. A., M. T. Roe, A. Y. Chen, R. S. Gupta, R. P. Giugliano, L. K. Newby, J. A. de Lemos, K. P. Alexander, T. A. Sanborn, and J. F. Saucedo. “Trends in use of anti-thrombotic agents and outcomes in patients with non-ST-segment elevation myocardial infarction (NSTEMI) managed with an invasive strategy.” Indian Heart J 68, no. 4 (July 2016): 464–72. https://doi.org/10.1016/j.ihj.2015.09.036.

PMID
27543467
Full Text

Afilalo, Jonathan, Sunghee Kim, Sean O’Brien, J Matthew Brennan, Fred H. Edwards, Michael J. Mack, James B. McClurken, et al. “Gait Speed and Operative Mortality in Older Adults Following Cardiac Surgery.” Jama Cardiol 1, no. 3 (June 1, 2016): 314–21. https://doi.org/10.1001/jamacardio.2016.0316.

PMID
27438112
Full Text

White, Harvey D., Cynthia M. Westerhout, Karen P. Alexander, Matthew T. Roe, Kenneth J. Winters, Derek D. Cyr, Keith Aa Fox, et al. “Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial.” Eur Heart J Acute Cardiovasc Care 5, no. 3 (June 2016): 231–42. https://doi.org/10.1177/2048872615581502.

PMID
25897147
Full Text

Pages