Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

O'Brien, EC, Simon, DN, Roe, MT, Wang, TY, Peterson, ED, and Alexander, KP. "Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry)." American Journal of Cardiology 115, no. 12 (January 1, 2015): 1655-1660.

Full Text

Lytle, BL, Li, S, Lofthus, DM, Thomas, L, Poteat, JL, Bhatt, DL, Cannon, CP, Fonarow, GC, Peterson, ED, Wang, TY, and Alexander, KP. "Targeted versus standard feedback: results from a randomized quality improvement trial." American heart journal 169, no. 1 (January 2015): 132-41.e2.

PMID
25497258
Full Text

Taha, S, D'Ascenzo, F, Moretti, C, Omedè, P, Montefusco, A, Bach, RG, Alexander, KP, Mehran, R, Ariza-Solé, A, Zoccai, GB, and Gaita, F. "Accuracy of bleeding scores for patients presenting with myocardial infarction: a meta-analysis of 9 studies and 13 759 patients." Postępy w Kardiologii Interwencyjnej = Advances in Interventional Cardiology 11, no. 3 (January 2015): 182-190.

PMID
26677357
Full Text

Kontos, MC, Rennyson, SL, Chen, AY, Alexander, KP, Peterson, ED, and Roe, MT. "The association of myocardial infarction process of care measures and in-hospital mortality: a report from the NCDR®." American heart journal 168, no. 5 (November 2014): 766-775.

PMID
25440806
Full Text

Fihn, SD, Blankenship, JC, Alexander, KP, Bittl, JA, Byrne, JG, Fletcher, BJ, Fonarow, GC, Lange, RA, Levine, GN, Maddox, TM, Naidu, SS, Ohman, EM, and Smith, PK. "2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons." Journal of the American College of Cardiology 64, no. 18 (November 2014): 1929-1949. (Review)

PMID
25077860
Full Text

Fihn, SD, Blankenship, JC, Alexander, KP, Bittl, JA, Byrne, JG, Fletcher, BJ, Fonarow, GC, Lange, RA, Levine, GN, Maddox, TM, Naidu, SS, Ohman, EM, and Smith, PK. "2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons." Circulation 130, no. 19 (November 2014): 1749-1767.

PMID
25070666
Full Text

Bangalore, S, Makani, H, Radford, M, Thakur, K, Toklu, B, Katz, SD, DiNicolantonio, JJ, Devereaux, PJ, Alexander, KP, Wetterslev, J, and Messerli, FH. "Clinical outcomes with β-blockers for myocardial infarction: a meta-analysis of randomized trials." The American journal of medicine 127, no. 10 (October 2014): 939-953.

PMID
24927909
Full Text

Hall, HM, de Lemos, JA, Enriquez, JR, McGuire, DK, Peng, SA, Alexander, KP, Roe, MT, Desai, N, Wiviott, SD, and Das, SR. "Contemporary patterns of discharge aspirin dosing after acute myocardial infarction in the United States: results from the National Cardiovascular Data Registry (NCDR)." Circulation. Cardiovascular quality and outcomes 7, no. 5 (September 2014): 701-707.

PMID
25116897
Full Text

Ohman, EM, and Alexander, KP. "The challenges with chronic angina." The New England journal of medicine 371, no. 12 (September 2014): 1152-1153.

PMID
25176137
Full Text

Bagai, A, Wang, Y, Wang, TY, Curtis, JP, Gurm, HS, Shah, B, Cheema, AN, Peterson, ED, Saucedo, JF, Granger, CB, Roe, MT, Bhatt, DL, McNamara, RL, and Alexander, KP. "In-hospital switching between clopidogrel and prasugrel among patients with acute myocardial infarction treated with percutaneous coronary intervention: insights into contemporary practice from the national cardiovascular data registry." Circulation. Cardiovascular interventions 7, no. 4 (August 5, 2014): 585-593.

PMID
25097196
Full Text

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