Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Alexander, Karen P., Kristi Prather, Kevin J. Anstrom, Daniel Mark, Ori Ben-Yehuda, Linda Davidson-Ray, Giora Weisz, Ramin Farzaneh-Far, Gregg Stone, and E Magnus Ohman. “Angina and Quality of Life Following PCI With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial.” In Circulation, 132:2273–2273. LIPPINCOTT WILLIAMS & WILKINS, 2015.

Scholars@Duke

Shen, Lan, Bimal R. Shah, Shuang Li, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, Eric D. Peterson, Ben He, and Matthew T. Roe. “The Association of Transfer Rate From Hospitals Without Revascularization Capabilities and Mortality Risk for Older Non-ST-Segment Elevation Myocardial Infarction Patients..” Clin Cardiol 38, no. 12 (December 2015): 733–39. https://doi.org/10.1002/clc.22480.

PMID
26511331
Full Text

Kang, Hyun-Jae, Dajuanicia Simon, Tracy Y. Wang, Karen P. Alexander, Myung Ho Jeong, Hyo-Soo Kim, Eric R. Bates, et al. “The Contemporary Use of Angiography and Revascularization Among Patients With Non-ST-Segment Elevation Myocardial Infarction in the United States Compared With South Korea..” Clin Cardiol 38, no. 12 (December 2015): 708–14. https://doi.org/10.1002/clc.22475.

PMID
26782938
Full Text

Zimerman, Andre, Amanda L. Stebbins, Renato D. Lopes, Patricia O. Guimaraes, Stefan K. James, John H. Alexander, Pierluigi Tricoci, et al. “ 48,000 Participants in Four Acute Coronary Syndrome Trials.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.

Scholars@Duke

Swiger, Kristopher J., Seth S. Martin, Fengming Tang, Michael J. Blaha, Roger S. Blumenthal, Karen P. Alexander, Suzanne V. Arnold, and John A. Spertus. “Cognitive and Physical Function by Statin Exposure in Elderly Individuals Following Acute Myocardial Infarction..” Clin Cardiol 38, no. 8 (August 2015): 455–61. https://doi.org/10.1002/clc.22423.

PMID
26212493
Full Text

Gupta, Aakriti, Philip Chui, Shengfan Zhou, John A. Spertus, Mary Geda, Nancy Lorenze, Ike Lee, et al. “Frequency and Effects of Excess Dosing of Anticoagulants in Patients ≤55 Years With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (from the VIRGO Study)..” Am J Cardiol 116, no. 1 (July 1, 2015): 1–7. https://doi.org/10.1016/j.amjcard.2015.03.032.

PMID
25937348
Full Text

O’Brien, Emily C., DaJuanicia N. Simon, Matthew T. Roe, Tracy Y. Wang, Eric D. Peterson, and Karen P. Alexander. “Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry)..” Am J Cardiol 115, no. 12 (June 15, 2015): 1655–60. https://doi.org/10.1016/j.amjcard.2015.03.007.

PMID
25888303
Full Text

Arnold, Suzanne V., Shu-Xia Li, Karen P. Alexander, John A. Spertus, Brahmajee K. Nallamothu, Jeptha P. Curtis, Mikhail Kosiborod, et al. “Hospital variability in use of anticoagulant strategies during acute myocardial infarction treated with an early invasive strategy..” J Am Heart Assoc 4, no. 6 (June 15, 2015). https://doi.org/10.1161/JAHA.115.002009.

PMID
26077589
Full Text

Lopes, Renato D., S Michael Gharacholou, DaJuanicia N. Holmes, Laine Thomas, Tracy Y. Wang, Matthew T. Roe, Eric D. Peterson, and Karen P. Alexander. “Cumulative incidence of death and rehospitalization among the elderly in the first year after NSTEMI..” Am J Med 128, no. 6 (June 2015): 582–90. https://doi.org/10.1016/j.amjmed.2014.12.032.

PMID
25660246
Full Text

Pages