Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Swiger, KJ, Martin, SS, Tang, F, Blaha, MJ, Blumenthal, RS, Alexander, KP, Arnold, SV, and Spertus, JA. "Cognitive and Physical Function by Statin Exposure in Elderly Individuals Following Acute Myocardial Infarction." Clinical Cardiology 38, no. 8 (August 1, 2015): 455-461.

Full Text

Swiger, KJ, Martin, SS, Tang, F, Blaha, MJ, Blumenthal, RS, Alexander, KP, Arnold, SV, and Spertus, JA. "Cognitive and Physical Function by Statin Exposure in Elderly Individuals Following Acute Myocardial Infarction." Clinical cardiology 38, no. 8 (August 2015): 455-461.

PMID
26212493
Full Text

Gupta, A, Chui, P, Zhou, S, Spertus, JA, Geda, M, Lorenze, N, Lee, I, D' Onofrio, G, Lichtman, JH, Alexander, KP, Krumholz, HM, and Curtis, JP. "Frequency and Effects of Excess Dosing of Anticoagulants in Patients ≤55 Years With Acute Myocardial Infarction Who Underwent Percutaneous Coronary Intervention (from the VIRGO Study)." The American journal of cardiology 116, no. 1 (July 2015): 1-7.

PMID
25937348
Full Text

Arnold, SV, Li, S-X, Alexander, KP, Spertus, JA, Nallamothu, BK, Curtis, JP, Kosiborod, M, Gupta, A, Wang, TY, Lin, H, Dharmarajan, K, Strait, KM, Lowe, TJ, and Krumholz, HM. "Hospital variability in use of anticoagulant strategies during acute myocardial infarction treated with an early invasive strategy." Journal of the American Heart Association 4, no. 6 (June 15, 2015): e002009-null.

PMID
26077589
Full Text

Lopes, RD, Gharacholou, SM, Holmes, DN, Thomas, L, Wang, TY, Roe, MT, Peterson, ED, and Alexander, KP. "Cumulative incidence of death and rehospitalization among the elderly in the first year after NSTEMI." The American Journal of Medicine 128, no. 6 (June 2015): 582-590.

PMID
25660246
Full Text

O'Brien, EC, Simon, DN, Roe, MT, Wang, TY, Peterson, ED, and Alexander, KP. "Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry)." The American Journal of Cardiology 115, no. 12 (June 2015): 1655-1660.

PMID
25888303
Full Text

Fihn, SD, Blankenship, JC, Alexander, KP, Bittl, JA, Byrne, JG, Fletcher, BJ, Fonarow, GC, Lange, RA, Levine, GN, Maddox, TM, Naidu, SS, Ohman, EM, Smith, PK, Anderson, JL, Halperin, JL, Albert, NM, Bozkurt, B, Brindis, RG, Curtis, LH, DeMets, D, Guyton, RA, Hochman, JS, Kovacs, RJ, Pressler, SJ, Sellke, FW, Shen, W-K, American College of Cardiology/Americal Heart Association Task Force on Practice Guidelines, , American Association for Thoracic Surgery, , Preventive Cardiovascular Nurses Association, , Society for Cardiovascular Angiography and Interventions, , and Society of Thoracic Surgeons, . "2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons." The Journal of Thoracic and Cardiovascular Surgery 149, no. 3 (March 2015): e5-23. (Review)

PMID
25827388
Full Text

Mehta, RH, Chen, AY, Alexander, KP, Ohman, EM, Roe, MT, and Peterson, ED. "Doing the right things and doing them the right way: association between hospital guideline adherence, dosing safety, and outcomes among patients with acute coronary syndrome." Circulation 131, no. 11 (March 2015): 980-987.

PMID
25688146
Full Text

O'Brien, EC, Simon, DJN, Roe, MT, Wang, TY, Peterson, ED, and Alexander, KP. "Statin Treatment by Low-Density Lipoprotein Cholesterol Levels in Patients With Non-ST-Segment Elevation Myocardial Infarction/Unstable Angina Pectoris (from the CRUSADE Registry)." American Journal of Cardiology 115, no. 12 (January 1, 2015): 1655-1660.

Full Text

Lytle, BL, Li, S, Lofthus, DM, Thomas, L, Poteat, JL, Bhatt, DL, Cannon, CP, Fonarow, GC, Peterson, ED, Wang, TY, and Alexander, KP. "Targeted versus standard feedback: results from a randomized quality improvement trial." American Heart Journal 169, no. 1 (January 2015): 132-41.e2.

PMID
25497258
Full Text

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