Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Mehta, Rajendra H., Anita Y. Chen, Karen P. Alexander, E Magnus Ohman, Matthew T. Roe, and Eric D. Peterson. “Doing the right things and doing them the right way: association between hospital guideline adherence, dosing safety, and outcomes among patients with acute coronary syndrome..” Circulation 131, no. 11 (March 17, 2015): 980–87. https://doi.org/10.1161/CIRCULATIONAHA.114.013451.

PMID
25688146
Full Text

Fihn, Stephan D., James C. Blankenship, Karen P. Alexander, John A. Bittl, John G. Byrne, Barbara J. Fletcher, Gregg C. Fonarow, et al. “2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons..” J Thorac Cardiovasc Surg 149, no. 3 (March 2015): e5-23. https://doi.org/10.1016/j.jtcvs.2014.11.002.

PMID
25827388
Full Text

Lytle, Barbara L., Shuang Li, David M. Lofthus, Laine Thomas, Jennifer L. Poteat, Deepak L. Bhatt, Christopher P. Cannon, et al. “Targeted versus standard feedback: results from a randomized quality improvement trial..” Am Heart J 169, no. 1 (January 2015): 132-41.e2. https://doi.org/10.1016/j.ahj.2014.08.017.

PMID
25497258
Full Text

Taha, Salma, Fabrizio D’Ascenzo, Claudio Moretti, Pierluigi Omedè, Antonio Montefusco, Richard G. Bach, Karen P. Alexander, et al. “Accuracy of bleeding scores for patients presenting with myocardial infarction: a meta-analysis of 9 studies and 13 759 patients..” Postepy Kardiol Interwencyjnej 11, no. 3 (2015): 182–90. https://doi.org/10.5114/pwki.2015.54011.

PMID
26677357
Full Text

Fihn, Stephan D., James C. Blankenship, Karen P. Alexander, John A. Bittl, John G. Byrne, Barbara J. Fletcher, Gregg C. Fonarow, et al. “2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons..” Circulation 130, no. 19 (November 4, 2014): 1749–67. https://doi.org/10.1161/CIR.0000000000000095.

PMID
25070666
Full Text

Fihn, Stephan D., James C. Blankenship, Karen P. Alexander, John A. Bittl, John G. Byrne, Barbara J. Fletcher, Gregg C. Fonarow, et al. “2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons..” J Am Coll Cardiol 64, no. 18 (November 4, 2014): 1929–49. https://doi.org/10.1016/j.jacc.2014.07.017.

PMID
25077860
Full Text

Kontos, Michael C., Stephen L. Rennyson, Anita Y. Chen, Karen P. Alexander, Eric D. Peterson, and Matthew T. Roe. “The association of myocardial infarction process of care measures and in-hospital mortality: a report from the NCDR®..” Am Heart J 168, no. 5 (November 2014): 766–75. https://doi.org/10.1016/j.ahj.2014.07.005.

PMID
25440806
Full Text

Bangalore, Sripal, Harikrishna Makani, Martha Radford, Kamia Thakur, Bora Toklu, Stuart D. Katz, James J. DiNicolantonio, et al. “Clinical outcomes with β-blockers for myocardial infarction: a meta-analysis of randomized trials..” Am J Med 127, no. 10 (October 2014): 939–53. https://doi.org/10.1016/j.amjmed.2014.05.032.

PMID
24927909
Full Text

Hall, Hurst M., James A. de Lemos, Jonathan R. Enriquez, Darren K. McGuire, S Andrew Peng, Karen P. Alexander, Matthew T. Roe, Nihar Desai, Stephen D. Wiviott, and Sandeep R. Das. “Contemporary patterns of discharge aspirin dosing after acute myocardial infarction in the United States: results from the National Cardiovascular Data Registry (NCDR)..” Circ Cardiovasc Qual Outcomes 7, no. 5 (September 2014): 701–7. https://doi.org/10.1161/CIRCOUTCOMES.113.000822.

PMID
25116897
Full Text

Pages