Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Xian, Y, Chen, AY, Thomas, L, Roe, MT, Subherwal, S, Cannon, CP, Pollack, CV, Fonarow, GC, Kosiborod, M, Peterson, ED, and Alexander, KP. "Sources of hospital-level variation in major bleeding among patients with non-st-segment elevation myocardial infarction: a report from the National Cardiovascular Data Registry (NCDR)." Circulation. Cardiovascular quality and outcomes 7, no. 2 (March 4, 2014): 236-243.

PMID
24594548
Full Text

Afilalo, J, Alexander, KP, Mack, MJ, Maurer, MS, Green, P, Allen, LA, Popma, JJ, Ferrucci, L, and Forman, DE. "Frailty assessment in the cardiovascular care of older adults." Journal of the American College of Cardiology 63, no. 8 (March 4, 2014): 747-762.

Full Text

Afilalo, J, Alexander, KP, Mack, MJ, Maurer, MS, Green, P, Allen, LA, Popma, JJ, Ferrucci, L, and Forman, DE. "Frailty assessment in the cardiovascular care of older adults." Journal of the American College of Cardiology 63, no. 8 (March 2014): 747-762. (Review)

PMID
24291279
Full Text

Waldo, SW, Brenner, DA, Li, S, Alexander, K, and Ganz, P. "Reperfusion times and in-hospital outcomes among patients with an isolated posterior myocardial infarction: insights from the National Cardiovascular Data Registry (NCDR)." American heart journal 167, no. 3 (March 2014): 350-354.

PMID
24576519
Full Text

Dodson, JA, Wang, Y, Chaudhry, SI, Alexander, KP, Masoudi, FA, Spertus, JA, Nallamothu, B, Chen, J, Arnold, SV, Dharmarajan, K, Shi, R, and Krumholz, HM. "National trends in rehospitalization for bleeding after acute myocardial infarction in the oldest old." March 2014.

Scholars@Duke

Van Diepen, S, Chen, AY, Wang, TY, Alexander, KP, Ezekowitz, JA, Peterson, ED, and Roe, MT. "Influence of heart failure symptoms and ejection fraction on short- and long-term outcomes for older patients with non-ST-segment elevation myocardial infarction." American Heart Journal 167, no. 2 (February 1, 2014).

Full Text

van Diepen, S, Chen, AY, Wang, TY, Alexander, KP, Ezekowitz, JA, Peterson, ED, and Roe, MT. "Influence of heart failure symptoms and ejection fraction on short- and long-term outcomes for older patients with non-ST-segment elevation myocardial infarction." American heart journal 167, no. 2 (February 2014): 267-273.e1.

PMID
24439989
Full Text

O'Brien, E, Subherwal, S, Roe, MT, Holmes, DN, Thomas, L, Alexander, KP, Wang, TY, and Peterson, ED. "Do patients treated at academic hospitals have better longitudinal outcomes after admission for non-ST-elevation myocardial infarction?." American Heart Journal 167, no. 5 (January 1, 2014): 762-769.

Full Text

Wang, TY, Magid, DJ, Ting, HH, Li, S, Alexander, KP, Roe, MT, and Peterson, ED. "The quality of antiplatelet and anticoagulant medication administration among ST-segment elevation myocardial infarction patients transferred for primary percutaneous coronary intervention." American Heart Journal 167, no. 6 (January 1, 2014): 833-839.

Full Text

Shen, L, Shah, BR, Nam, A, Holmes, D, Alexander, KP, Bhatt, DL, Ho, PM, Peterson, ED, He, B, and Roe, MT. "Implications of prior myocardial infarction for patients presenting with an acute myocardial infarction." American Heart Journal 167, no. 6 (January 1, 2014): 840-845.

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