Karen Patton Alexander, MD

Professor of Medicine
Member in the Duke Clinical Research Institute
Campus mail 2400 Pratt St Ste 7068, Durham, NC 27705
Phone (919) 668-8871

My research focus is on cardiovascular disease management and outcomes in special populations, specifically older adults. Historically there has been a lack of randomized controlled data regarding treatment efficacy and outcomes in this growing population. Because of this, certain therapies may have different risk benefit profiles, which may cause physicians to alter their therapeutic interventions. My research explores evidence based treatment for older adults, including preferences and decision-making as well as frailty and aging assessments in clinical trials and registries. Diagnosis and management of stable ischemic heart disease is also an area of focus.

Education and Training

  • Cardiology Fellow, Medicine, Duke University, 1995 - 1998
  • Resident, Internal Medicine, Brigham and Women's Hospital, 1993 - 1995
  • Intern, Internal Medicine, Brigham and Women's Hospital, 1992 - 1993
  • M.D., Duke University, 1992

Publications

Weisz, Giora, Philippe Généreux, Andres Iñiguez, Aleksander Zurakowski, Michael Shechter, Karen P. Alexander, Ovidiu Dressler, et al. “Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial.” Lancet 387, no. 10014 (January 9, 2016): 136–45. https://doi.org/10.1016/S0140-6736(15)00459-6.

PMID
26474810
Full Text

Alexander, Karen P., Giora Weisz, Kristi Prather, Stefan James, Daniel B. Mark, Kevin J. Anstrom, Linda Davidson-Ray, et al. “Effects of Ranolazine on Angina and Quality of Life After Percutaneous Coronary Intervention With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial.” Circulation 133, no. 1 (January 5, 2016): 39–47. https://doi.org/10.1161/CIRCULATIONAHA.115.019768.

PMID
26555329
Full Text

Forman, Daniel E., Karen Alexander, Ralph G. Brindis, Anne B. Curtis, Mathew Maurer, Michael W. Rich, Laurence Sperling, and Nanette K. Wenger. “Improved Cardiovascular Disease Outcomes in Older Adults.” F1000res 5 (2016). https://doi.org/10.12688/f1000research.7088.1.

PMID
26918183
Full Text

Qintar, Mohammed, John A. Spertus, Kensey L. Gosch, John Beltrame, Faraz Kureshi, Ali Shafiq, Tracie Breeding, Karen P. Alexander, and Suzanne V. Arnold. “Effect of angina under-recognition on treatment in outpatients with stable ischaemic heart disease.” Eur Heart J Qual Care Clin Outcomes 2, no. 3 (2016): 208–14. https://doi.org/10.1093/ehjqcco/qcw016.

PMID
28239488
Full Text

Alexander, Karen P., Kristi Prather, Kevin J. Anstrom, Daniel Mark, Ori Ben-Yehuda, Linda Davidson-Ray, Giora Weisz, Ramin Farzaneh-Far, Gregg Stone, and E Magnus Ohman. “Angina and Quality of Life Following PCI With Incomplete Revascularization: Results From the Ranolazine for Incomplete Vessel Revascularization (RIVER-PCI) Trial.” In Circulation, 132:2273–2273. LIPPINCOTT WILLIAMS & WILKINS, 2015.

Scholars@Duke

Shen, Lan, Bimal R. Shah, Shuang Li, Laine Thomas, Tracy Y. Wang, Karen P. Alexander, Eric D. Peterson, Ben He, and Matthew T. Roe. “The Association of Transfer Rate From Hospitals Without Revascularization Capabilities and Mortality Risk for Older Non-ST-Segment Elevation Myocardial Infarction Patients.” Clin Cardiol 38, no. 12 (December 2015): 733–39. https://doi.org/10.1002/clc.22480.

PMID
26511331
Full Text

Kang, Hyun-Jae, Dajuanicia Simon, Tracy Y. Wang, Karen P. Alexander, Myung Ho Jeong, Hyo-Soo Kim, Eric R. Bates, et al. “The Contemporary Use of Angiography and Revascularization Among Patients With Non-ST-Segment Elevation Myocardial Infarction in the United States Compared With South Korea.” Clin Cardiol 38, no. 12 (December 2015): 708–14. https://doi.org/10.1002/clc.22475.

PMID
26782938
Full Text

Zimerman, Andre, Amanda L. Stebbins, Renato D. Lopes, Patricia O. Guimaraes, Stefan K. James, John H. Alexander, Pierluigi Tricoci, et al. “ 48,000 Participants in Four Acute Coronary Syndrome Trials.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.

Scholars@Duke

Pages