Kathleen Anne Welsh-Bohmer, PhD

Professor of Psychiatry and Behavioral Sciences
Director, of Alzheimer's Disease Research Center
Professor in Neurology
Faculty Network Member of the Duke Institute for Brain Sciences
Member in the Duke Clinical Research Institute
Campus mail 2200 W Main St Ste A200, Durham, NC 27705
Phone (919) 668-0820
Email address kathleen.welshbohmer@duke.edu

Dr. Kathleen Welsh-Bohmer is a Professor of Psychiatry with a secondary appointment in the Department of Neurology. She is also the Chief of the Medical Psychology CPU, the professional home for the over 200 academic psychologists within Duke Medical Center.  

Clinically trained as a neuropsychologist, Dr. Welsh-Bohmer's research activities have been focused around developing effective prevention and treatment strategies to delay the onset of cognitive disorders occurring in later life.  Since 2006 she has directed the Joseph and Kathleen Bryan Alzheimer’s Center in the Department of Neurology, where she leads a large multidisciplinary team focused on discovering the biological basis of Alzheimer’s disease and developing methods to enhance early diagnosis and speed drug discovery.

Currently, she oversees the neuropsychology scientific operations of a Phase III global clinical trial to delay the onset of Alzheimer’s disease entitled the “TOMMORROW” study (Takeda Pharmaceutical Company funded). The methods her team is developing for this study fill an information void and have implications for accelerating global clinical trials in Alzheimer’s disease prevention.

Education and Training

  • Ph.D., University of Virginia, 1985

Publications

Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial..” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.

PMID
30870159
Full Text

Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Pao-Hwa Lin, Lawrence Liao, Kathleen A. Welsh-Bohmer, et al. “Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial..” Neurology 92, no. 3 (January 15, 2019): e212–23. https://doi.org/10.1212/WNL.0000000000006784.

PMID
30568005
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Burns, D. K., C. Chiang, K. A. Welsh-Bohmer, S. K. Brannan, M. Culp, J. O’Neil, G. Runyan, et al. “The TOMMORROW study: Design of an Alzheimer's disease delay-of-onset clinical trial.” Alzheimer’S and Dementia: Translational Research and Clinical Interventions 5 (January 1, 2019): 661–70. https://doi.org/10.1016/j.trci.2019.09.010.

Full Text

Tsui-Caldwell, Y. H. W., T. J. Farrer, Z. McDonnell, Z. Christensen, C. Finuf, E. D. Bigler, J. T. Tschanz, M. C. Norton, and K. A. Welsh-Bohmer. “MRI Clinical Ratings and Cognitive Function in a Cross-Sectional Population Study of Dementia: The Cache County Memory Study..” J Prev Alzheimers Dis 6, no. 2 (2019): 100–107. https://doi.org/10.14283/jpad.2019.1.

PMID
30756116
Full Text

Knodt, Annchen R., James R. Burke, Kathleen A. Welsh-Bohmer, Brenda L. Plassman, Daniel K. Burns, Stephen K. Brannan, Michael Kukulka, Jingtao Wu, and Ahmad R. Hariri. “Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults..” Alzheimers Dement (N Y) 5 (2019): 254–63. https://doi.org/10.1016/j.trci.2019.05.004.

PMID
31304231
Full Text

Smith, Patrick J., Stephanie Mabe, Andrew Sherwood, Michael A. Babyak, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, William Kraus, James Burke, Alan Hinderliter, and James A. Blumenthal. “Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment..” J Alzheimers Dis 71, no. 3 (2019): 921–29. https://doi.org/10.3233/JAD-190569.

PMID
31476159
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Deming, Yuetiva, Logan Dumitrescu, Lisa L. Barnes, Madhav Thambisetty, Brian Kunkle, Katherine A. Gifford, William S. Bush, et al. “Sex-specific genetic predictors of Alzheimer's disease biomarkers..” Acta Neuropathol 136, no. 6 (December 2018): 857–72. https://doi.org/10.1007/s00401-018-1881-4.

PMID
29967939
Full Text

Hohman, Timothy J., Logan Dumitrescu, Lisa L. Barnes, Madhav Thambisetty, Gary Beecham, Brian Kunkle, Katherine A. Gifford, et al. “Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau..” Jama Neurol 75, no. 8 (August 1, 2018): 989–98. https://doi.org/10.1001/jamaneurol.2018.0821.

PMID
29801024
Full Text

Browndyke, Jeffrey N., Miles Berger, Patrick J. Smith, Todd B. Harshbarger, Zachary A. Monge, Viral Panchal, Tiffany L. Bisanar, et al. “Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults..” Hum Brain Mapp 39, no. 2 (February 2018): 985–1003. https://doi.org/10.1002/hbm.23898.

PMID
29164774
Full Text

Pages