Kathleen Anne Welsh-Bohmer, PhD

Professor of Psychiatry and Behavioral Sciences
Director, of Alzheimer's Disease Research Center
Professor in Neurology
Professor of Psychology and Neuroscience
Faculty Network Member of the Duke Institute for Brain Sciences
Campus mail 2200 W Main St Ste A200, Durham, NC 27705
Phone (919) 668-0820
Email address kathleen.welshbohmer@duke.edu

Dr. Kathleen Welsh-Bohmer is a Professor of Psychiatry with a secondary appointment in the Department of Neurology. She is also the Chief of the Medical Psychology CPU, the professional home for the over 200 academic psychologists within Duke Medical Center.  

Clinically trained as a neuropsychologist, Dr. Welsh-Bohmer's research activities have been focused around developing effective prevention and treatment strategies to delay the onset of cognitive disorders occurring in later life.  Since 2006 she has directed the Joseph and Kathleen Bryan Alzheimer’s Center in the Department of Neurology, where she leads a large multidisciplinary team focused on discovering the biological basis of Alzheimer’s disease and developing methods to enhance early diagnosis and speed drug discovery.

Currently, she oversees the neuropsychology scientific operations of a Phase III global clinical trial to delay the onset of Alzheimer’s disease entitled the “TOMMORROW” study (Takeda Pharmaceutical Company funded). The methods her team is developing for this study fill an information void and have implications for accelerating global clinical trials in Alzheimer’s disease prevention.

Education and Training

  • Ph.D., University of Virginia, 1197

Publications

Sims, R, van der Lee, SJ, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, S-H, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, C, Forstner, AJ, Ahmad, S, and Li, H et al. "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nature genetics 49, no. 9 (September 2017): 1373-1384.

PMID
28714976
Full Text

Jun, GR, Chung, J, Mez, J, Barber, R, Beecham, GW, Bennett, DA, Buxbaum, JD, Byrd, GS, Carrasquillo, MM, Crane, PK, Cruchaga, C, De Jager, P, Ertekin-Taner, N, Evans, D, Fallin, MD, Foroud, TM, Friedland, RP, Goate, AM, Graff-Radford, NR, Hendrie, H, Hall, KS, Hamilton-Nelson, KL, Inzelberg, R, Kamboh, MI, Kauwe, JSK, Kukull, WA, Kunkle, BW, Kuwano, R, Larson, EB, Logue, MW, Manly, JJ, Martin, ER, Montine, TJ, Mukherjee, S, Naj, A, Reiman, EM, Reitz, C, Sherva, R, and St George-Hyslop, PH et al. "Transethnic genome-wide scan identifies novel Alzheimer's disease loci." Alzheimer's & dementia : the journal of the Alzheimer's Association 13, no. 7 (July 2017): 727-738.

PMID
28183528
Full Text

Blumenthal, JA, Smith, PJ, Mabe, S, Hinderliter, A, Welsh-Bohmer, K, Browndyke, JN, Lin, P-H, Kraus, W, Doraiswamy, PM, Burke, J, and Sherwood, A. "Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment." Psychosomatic medicine 79, no. 6 (July 2017): 719-727.

PMID
28437380
Full Text

Browndyke, JN, Berger, M, Harshbarger, TB, Smith, PJ, White, W, Bisanar, TL, Alexander, JH, Gaca, JG, Welsh-Bohmer, K, Newman, MF, and Mathew, JP. "Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings." Journal of the American Geriatrics Society 65, no. 1 (January 2017): e6-e12.

PMID
27858963
Full Text

Lutz, MW, Crenshaw, D, Welsh-Bohmer, KA, Burns, DK, and Roses, AD. "New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics." Current neurology and neuroscience reports 16, no. 5 (May 2016): 48-. (Review)

PMID
27039903
Full Text

Ridge, PG, Hoyt, KB, Boehme, K, Mukherjee, S, Crane, PK, Haines, JL, Mayeux, R, Farrer, LA, Pericak-Vance, MA, Schellenberg, GD, Kauwe, JSK, Adams, PM, Albert, MS, Albin, RL, Apostolova, LG, Arnold, SE, Asthana, S, Atwood, CS, Baldwin, CT, Barber, RC, Barmada, MM, Barnes, LL, Barral, S, Beach, TG, Becker, JT, Beecham, GW, Beekly, D, Bennett, DA, Bigio, EH, Bird, TD, Blacker, D, Boeve, BF, Bowen, JD, Boxer, A, Burke, JR, Burns, JM, Buxbaum, JD, Cairns, NJ, Cantwell, LB, Cao, C, and Carlson, CS et al. "Assessment of the genetic variance of late-onset Alzheimer's disease." Neurobiology of Aging 41 (May 2016): 200.e13-200.e20.

Full Text

Weninger, S, Carrillo, MC, Dunn, B, Aisen, PS, Bateman, RJ, Kotz, JD, Langbaum, JB, Mills, SL, Reiman, EM, Sperling, R, Santacruz, AM, Tariot, PN, and Welsh-Bohmer, KA. "Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials." Alzheimer's & dementia : the journal of the Alzheimer's Association 12, no. 5 (May 2016): 631-632.

PMID
27157073
Full Text

Perry, DC, Sturm, VE, Peterson, MJ, Pieper, CF, Bullock, T, Boeve, BF, Miller, BL, Guskiewicz, KM, Berger, MS, Kramer, JH, and Welsh-Bohmer, KA. "Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis." Journal of neurosurgery 124, no. 2 (February 2016): 511-526. (Review)

PMID
26315003
Full Text

Foster, CM, Addis, DR, Ford, JH, Kaufer, DI, Burke, JR, Browndyke, JN, Welsh-Bohmer, KA, and Giovanello, KS. "Prefrontal contributions to relational encoding in amnestic mild cognitive impairment." NeuroImage : Clinical 11 (January 15, 2016): 158-166.

PMID
26937384
Full Text

Reiman, EM, Langbaum, JB, Tariot, PN, Lopera, F, Bateman, RJ, Morris, JC, Sperling, RA, Aisen, PS, Roses, AD, Welsh-Bohmer, KA, Carrillo, MC, and Weninger, S. "CAP--advancing the evaluation of preclinical Alzheimer disease treatments." Nature reviews. Neurology 12, no. 1 (January 2016): 56-61. (Review)

PMID
26416539
Full Text

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