Kathleen Anne Welsh-Bohmer, PhD

Professor of Psychiatry and Behavioral Sciences
Director, of Alzheimer's Disease Research Center
Professor in Neurology
Professor of Psychology and Neuroscience
Faculty Network Member of the Duke Institute for Brain Sciences
Member in the Duke Clinical Research Institute
Campus mail 2200 W Main St Ste A200, Durham, NC 27705
Phone (919) 668-0820
Email address kathleen.welshbohmer@duke.edu

Dr. Kathleen Welsh-Bohmer is a Professor of Psychiatry with a secondary appointment in the Department of Neurology. She is also the Chief of the Medical Psychology CPU, the professional home for the over 200 academic psychologists within Duke Medical Center.  

Clinically trained as a neuropsychologist, Dr. Welsh-Bohmer's research activities have been focused around developing effective prevention and treatment strategies to delay the onset of cognitive disorders occurring in later life.  Since 2006 she has directed the Joseph and Kathleen Bryan Alzheimer’s Center in the Department of Neurology, where she leads a large multidisciplinary team focused on discovering the biological basis of Alzheimer’s disease and developing methods to enhance early diagnosis and speed drug discovery.

Currently, she oversees the neuropsychology scientific operations of a Phase III global clinical trial to delay the onset of Alzheimer’s disease entitled the “TOMMORROW” study (Takeda Pharmaceutical Company funded). The methods her team is developing for this study fill an information void and have implications for accelerating global clinical trials in Alzheimer’s disease prevention.

Education and Training

  • Ph.D., University of Virginia, 1985

Publications

Hohman, TJ, Dumitrescu, L, Barnes, LL, Thambisetty, M, Beecham, G, Kunkle, B, Gifford, KA, Bush, WS, Chibnik, LB, Mukherjee, S, De Jager, PL, Kukull, W, Crane, PK, Resnick, SM, Keene, CD, Montine, TJ, Schellenberg, GD, Haines, JL, Zetterberg, H, Blennow, K, Larson, EB, Johnson, SC, Albert, M, Bennett, DA, Schneider, JA, Jefferson, AL, and Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, . "Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau." Jama Neurology 75, no. 8 (August 2018): 989-998.

PMID
29801024
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Browndyke, JN, Berger, M, Smith, PJ, Harshbarger, TB, Monge, ZA, Panchal, V, Bisanar, TL, Glower, DD, Alexander, JH, Cabeza, R, Welsh-Bohmer, K, Newman, MF, Mathew, JP, and Duke Neurologic Outcomes Research Group (NORG), . "Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults." Human Brain Mapping 39, no. 2 (February 2018): 985-1003.

PMID
29164774
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Weintraub, S, Carrillo, MC, Farias, ST, Goldberg, TE, Hendrix, JA, Jaeger, J, Knopman, DS, Langbaum, JB, Park, DC, Ropacki, MT, Sikkes, SAM, Welsh-Bohmer, KA, Bain, LJ, Brashear, R, Budur, K, Graf, A, Martenyi, F, Storck, MS, and Randolph, C. "Measuring cognition and function in the preclinical stage of Alzheimer's disease." Alzheimer's and Dementia: Translational Research and Clinical Interventions 4 (January 1, 2018): 64-75.

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Peloso, GM, van der Lee, SJ, Sims, R, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, SH, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, , Forstner, AJ, Ahmad, S, Li, H, Bacq, D, Harold, D, Satizabal, CL, Valladares, O, Squassina, A, Thomas, R, Brody, JA, Qu, L, Sánchez-Juan, P, Morgan, T, Wolters, FJ, Zhao, Y, Garcia, FS, Denning, N, Fornage, M, Malamon, J, Naranjo, MCD, Majounie, E, Mosley, TH, Dombroski, B, Wallon, D, Lupton, MK, Dupuis, J, Whitehead, P, Fratiglioni, L, Medway, C, Jian, X, Mukherjee, S, Keller, L, Brown, K, Lin, H, Cantwell, LB, Panza, F, McGuinness, B, Moreno-Grau, S, Burgess, JD, Solfrizzi, V, Proitsi, P, Adams, HH, Allen, M, Seripa, D, Pastor, P, Cupples, LA, Price, ND, Hannequin, D, Frank-García, A, Levy, D, Chakrabarty, P, Caffarra, P, Giegling, I, Beiser, AS, Giedraitis, V, Hampel, H, Garcia, ME, Wang, X, Lannfelt, L, Mecocci, P, Eiriksdottir, G, and Crane, PK. "Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease." Alzheimer'S and Dementia: Diagnosis, Assessment and Disease Monitoring 10 (January 1, 2018): 595-598.

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Morrison, RL, Pei, H, Novak, G, Kaufer, DI, Welsh-Bohmer, KA, Ruhmel, S, and Narayan, VA. "A computerized, self-administered test of verbal episodic memory in elderly patients with mild cognitive impairment and healthy participants: A randomized, crossover, validation study." Alzheimer'S and Dementia: Diagnosis, Assessment and Disease Monitoring 10 (January 1, 2018): 647-656.

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Weintraub, S, Besser, L, Dodge, HH, Teylan, M, Ferris, S, Goldstein, FC, Giordani, B, Kramer, J, Loewenstein, D, Marson, D, Mungas, D, Salmon, D, Welsh-Bohmer, K, Zhou, X-H, Shirk, SD, Atri, A, Kukull, WA, Phelps, C, and Morris, JC. "Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS)." Alzheimer Disease and Associated Disorders 32, no. 1 (January 2018): 10-17.

PMID
29240561
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Romero, HR, Monsch, AU, Hayden, KM, Plassman, BL, Atkins, AS, Keefe, RSE, Brewster, S, Chiang, C, O'Neil, J, Runyan, G, Atkinson, MJ, Crawford, S, Budur, K, Burns, DK, and Welsh-Bohmer, KA. "TOMMORROW neuropsychological battery: German language validation and normative study." Alzheimer'S & Dementia (New York, N. Y.) 4 (January 2018): 314-323.

PMID
30094331
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Atkins, AS, Khan, A, Ulshen, D, Vaughan, A, Balentin, D, Dickerson, H, Liharska, LE, Plassman, B, Welsh-Bohmer, K, and Keefe, RSE. "Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT)." The Journal of Prevention of Alzheimer'S Disease 5, no. 4 (January 2018): 216-234.

PMID
30298179
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Sims, R, van der Lee, SJ, Naj, AC, Bellenguez, C, Badarinarayan, N, Jakobsdottir, J, Kunkle, BW, Boland, A, Raybould, R, Bis, JC, Martin, ER, Grenier-Boley, B, Heilmann-Heimbach, S, Chouraki, V, Kuzma, AB, Sleegers, K, Vronskaya, M, Ruiz, A, Graham, RR, Olaso, R, Hoffmann, P, Grove, ML, Vardarajan, BN, Hiltunen, M, Nöthen, MM, White, CC, Hamilton-Nelson, KL, Epelbaum, J, Maier, W, Choi, S-H, Beecham, GW, Dulary, C, Herms, S, Smith, AV, Funk, CC, Derbois, C, Forstner, AJ, Ahmad, S, Li, H, Bacq, D, Harold, D, Satizabal, CL, Valladares, O, Squassina, A, Thomas, R, Brody, JA, Qu, L, Sánchez-Juan, P, Morgan, T, Wolters, FJ, Zhao, Y, Garcia, FS, Denning, N, Fornage, M, Malamon, J, Naranjo, MCD, Majounie, E, Mosley, TH, Dombroski, B, Wallon, D, Lupton, MK, Dupuis, J, Whitehead, P, Fratiglioni, L, Medway, C, Jian, X, Mukherjee, S, Keller, L, Brown, K, Lin, H, Cantwell, LB, Panza, F, McGuinness, B, Moreno-Grau, S, Burgess, JD, Solfrizzi, V, Proitsi, P, Adams, HH, Allen, M, Seripa, D, Pastor, P, Cupples, LA, Price, ND, Hannequin, D, Frank-García, A, Levy, D, Chakrabarty, P, Caffarra, P, Giegling, I, Beiser, AS, Giedraitis, V, Hampel, H, Garcia, ME, Wang, X, Lannfelt, L, Mecocci, P, Eiriksdottir, G, Crane, PK, Pasquier, F, Boccardi, V, Henández, I, Barber, RC, Scherer, M, Tarraga, L, Adams, PM, Leber, M, Chen, Y, Albert, MS, Riedel-Heller, S, Emilsson, V, Beekly, D, Braae, A, Schmidt, R, Blacker, D, Masullo, C, Schmidt, H, Doody, RS, Spalletta, G, Longstreth, WT, Fairchild, TJ, Bossù, P, Lopez, OL, Frosch, MP, Sacchinelli, E, Ghetti, B, Yang, Q, Huebinger, RM, Jessen, F, Li, S, Kamboh, MI, Morris, J, Sotolongo-Grau, O, Katz, MJ, Corcoran, C, Dunstan, M, Braddel, A, Thomas, C, Meggy, A, Marshall, R, Gerrish, A, Chapman, J, Aguilar, M, Taylor, S, Hill, M, Fairén, MD, Hodges, A, Vellas, B, Soininen, H, Kloszewska, I, Daniilidou, M, Uphill, J, Patel, Y, Hughes, JT, Lord, J, Turton, J, Hartmann, AM, Cecchetti, R, Fenoglio, C, Serpente, M, Arcaro, M, Caltagirone, C, Orfei, MD, Ciaramella, A, Pichler, S, Mayhaus, M, Gu, W, Lleó, A, Fortea, J, Blesa, R, Barber, IS, Brookes, K, Cupidi, C, Maletta, RG, Carrell, D, Sorbi, S, Moebus, S, Urbano, M, Pilotto, A, Kornhuber, J, Bosco, P, Todd, S, Craig, D, Johnston, J, Gill, M, Lawlor, B, Lynch, A, Fox, NC, Hardy, J, ARUK Consortium, , Albin, RL, Apostolova, LG, Arnold, SE, Asthana, S, Atwood, CS, Baldwin, CT, Barnes, LL, Barral, S, Beach, TG, Becker, JT, Bigio, EH, Bird, TD, Boeve, BF, Bowen, JD, Boxer, A, Burke, JR, Burns, JM, Buxbaum, JD, Cairns, NJ, Cao, C, Carlson, CS, Carlsson, CM, Carney, RM, Carrasquillo, MM, Carroll, SL, Diaz, CC, Chui, HC, Clark, DG, Cribbs, DH, Crocco, EA, DeCarli, C, Dick, M, Duara, R, Evans, DA, Faber, KM, Fallon, KB, Fardo, DW, Farlow, MR, Ferris, S, Foroud, TM, Galasko, DR, Gearing, M, Geschwind, DH, Gilbert, JR, Graff-Radford, NR, Green, RC, Growdon, JH, Hamilton, RL, Harrell, LE, Honig, LS, Huentelman, MJ, Hulette, CM, Hyman, BT, Jarvik, GP, Abner, E, Jin, L-W, Jun, G, Karydas, A, Kaye, JA, Kim, R, Kowall, NW, Kramer, JH, LaFerla, FM, Lah, JJ, Leverenz, JB, Levey, AI, Li, G, Lieberman, AP, Lunetta, KL, Lyketsos, CG, Marson, DC, Martiniuk, F, Mash, DC, Masliah, E, McCormick, WC, McCurry, SM, McDavid, AN, McKee, AC, Mesulam, M, Miller, BL, Miller, CA, Miller, JW, Morris, JC, Murrell, JR, Myers, AJ, O'Bryant, S, Olichney, JM, Pankratz, VS, Parisi, JE, Paulson, HL, Perry, W, Peskind, E, Pierce, A, Poon, WW, Potter, H, Quinn, JF, Raj, A, Raskind, M, Reisberg, B, Reitz, C, Ringman, JM, Roberson, ED, Rogaeva, E, Rosen, HJ, Rosenberg, RN, Sager, MA, Saykin, AJ, Schneider, JA, Schneider, LS, Seeley, WW, Smith, AG, Sonnen, JA, Spina, S, Stern, RA, Swerdlow, RH, Tanzi, RE, Thornton-Wells, TA, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Van Eldik, LJ, Vinters, HV, Vonsattel, JP, Weintraub, S, Welsh-Bohmer, KA, Wilhelmsen, KC, Williamson, J, Wingo, TS, Woltjer, RL, Wright, CB, Yu, C-E, Yu, L, Garzia, F, Golamaully, F, Septier, G, Engelborghs, S, Vandenberghe, R, De Deyn, PP, Fernadez, CM, Benito, YA, Thonberg, H, Forsell, C, Lilius, L, Kinhult-Stählbom, A, Kilander, L, Brundin, R, Concari, L, Helisalmi, S, Koivisto, AM, Haapasalo, A, Dermecourt, V, Fievet, N, Hanon, O, Dufouil, C, Brice, A, Ritchie, K, Dubois, B, Himali, JJ, Keene, CD, Tschanz, J, Fitzpatrick, AL, Kukull, WA, Norton, M, Aspelund, T, Larson, EB, Munger, R, Rotter, JI, Lipton, RB, Bullido, MJ, Hofman, A, Montine, TJ, Coto, E, Boerwinkle, E, Petersen, RC, Alvarez, V, Rivadeneira, F, Reiman, EM, Gallo, M, O'Donnell, CJ, Reisch, JS, Bruni, AC, Royall, DR, Dichgans, M, Sano, M, Galimberti, D, St George-Hyslop, P, Scarpini, E, Tsuang, DW, Mancuso, M, Bonuccelli, U, Winslow, AR, Daniele, A, Wu, C-K, GERAD/PERADES, CHARGE, ADGC, EADI, , Peters, O, Nacmias, B, Riemenschneider, M, Heun, R, Brayne, C, Rubinsztein, DC, Bras, J, Guerreiro, R, Al-Chalabi, A, Shaw, CE, Collinge, J, Mann, D, Tsolaki, M, Clarimón, J, Sussams, R, Lovestone, S, O'Donovan, MC, Owen, MJ, Behrens, TW, Mead, S, Goate, AM, Uitterlinden, AG, Holmes, C, Cruchaga, C, Ingelsson, M, Bennett, DA, Powell, J, Golde, TE, Graff, C, De Jager, PL, Morgan, K, Ertekin-Taner, N, Combarros, O, Psaty, BM, Passmore, P, Younkin, SG, Berr, C, Gudnason, V, Rujescu, D, Dickson, DW, Dartigues, J-F, DeStefano, AL, Ortega-Cubero, S, Hakonarson, H, Campion, D, Boada, M, Kauwe, JK, Farrer, LA, Van Broeckhoven, C, Ikram, MA, Jones, L, Haines, JL, Tzourio, C, Launer, LJ, Escott-Price, V, Mayeux, R, Deleuze, J-F, Amin, N, Holmans, PA, Pericak-Vance, MA, Amouyel, P, van Duijn, CM, Ramirez, A, Wang, L-S, Lambert, J-C, Seshadri, S, Williams, J, and Schellenberg, GD. "Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease." Nature Genetics 49, no. 9 (September 2017): 1373-1384.

PMID
28714976
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Jun, GR, Chung, J, Mez, J, Barber, R, Beecham, GW, Bennett, DA, Buxbaum, JD, Byrd, GS, Carrasquillo, MM, Crane, PK, Cruchaga, C, De Jager, P, Ertekin-Taner, N, Evans, D, Fallin, MD, Foroud, TM, Friedland, RP, Goate, AM, Graff-Radford, NR, Hendrie, H, Hall, KS, Hamilton-Nelson, KL, Inzelberg, R, Kamboh, MI, Kauwe, JSK, Kukull, WA, Kunkle, BW, Kuwano, R, Larson, EB, Logue, MW, Manly, JJ, Martin, ER, Montine, TJ, Mukherjee, S, Naj, A, Reiman, EM, Reitz, C, Sherva, R, St George-Hyslop, PH, Thornton, T, Younkin, SG, Vardarajan, BN, Wang, L-S, Wendlund, JR, Winslow, AR, Alzheimer's Disease Genetics Consortium, , Haines, J, Mayeux, R, Pericak-Vance, MA, Schellenberg, G, Lunetta, KL, and Farrer, LA. "Transethnic genome-wide scan identifies novel Alzheimer's disease loci." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 13, no. 7 (July 2017): 727-738.

PMID
28183528
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