Keith Michael Sullivan, MD

Professor of Medicine
James B. Wyngaarden Professor of Medicine, in the School of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address sulli025@mc.duke.edu

Research areas

  • Late effects of cancer treatment and stem cell transplantation 
  • Chronic graft-versus-host disease 
  • Transplantation for sickle cell and autoimmune diseases 
  • Knowledge engineering

Overview
Early on, Dr. Sullivan and the team at Fred Hutchinson Cancer Research Center developed a systematic investigative approach for the diagnosis and treatment of chronic graft-versus-host disease (GVHD), the major cause of late morbidity and non-relapse mortality following allogeneic stem cell transplantation (SCT). As a result of this work, it became clear that blood and marrow transplant recipients require systematic long-term follow-up to evaluate and treat late complications of high-dose chemoradiotherapy and SCT.

The program grew into a large multidisciplinary team, resulting in improvement in patient outcome and quality of life. Through the late events project, he also contributed to outcomes research, computer decision support systems, and knowledge engineering for follow-up care. With quality of life as a focus, research pursued the application of SCT to diseases with high morbidity but little immediate mortality. For young patients with advanced, symptomatic sickle cell disease, myeloablative conditioning and SCT from an HLA-identical sibling has led to an 86% long-term survival free of sickle cell disease. For individuals with autoimmune diseases such as multiple sclerosis, scleroderma, and systemic lupus erythematosus, current therapy is often incomplete and significant morbidity from the disease or its treatment is observed.

Recent preclinical and clinical data suggest that high-dose immunosupression and SCT can halt the progression and, in some settings, reverse the course of autoimmune diseases. Since his arrival at Duke University, over 30 centers nationwide are participating in Duke-led phase II and III trials to test the toxicity, efficacy, and quality of life following autologous and allogeneic stem cell transplantation for autoimmune diseases.

These trials will also serve as platforms to study the immune repertoire and mechanistic pathways before and after SCT to gain greater insight into the basic mechanisms of autoimmunity.

A national repository of tissue and cell specimens is also part of these NIH-supported trials to further promote scientific study from these unique patients.

In Their Words

Education and Training

  • M.D., Indiana University at Indianapolis, 1971

Publications

Goerner, M, Gooley, T, Flowers, MED, Sullivan, KM, Kiem, H-P, Sanders, JE, Martin, PJ, and Storb, R. "Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 8, no. 1 (January 2002): 47-56.

PMID
11858190
Full Text

Storek, J, Joseph, A, Espino, G, Dawson, MA, Douek, DC, Sullivan, KM, Flowers, ME, Martin, P, Mathioudakis, G, Nash, RA, Storb, R, Appelbaum, FR, and Maloney, DG. "Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation." Blood 98, no. 13 (December 15, 2001): 3505-3512.

PMID
11739150
Scholars@Duke

Socié, G, Clift, RA, Blaise, D, Devergie, A, Ringden, O, Martin, PJ, Remberger, M, Deeg, HJ, Ruutu, T, Michallet, M, Sullivan, KM, and Chevret, S. "Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies." Blood 98, no. 13 (December 2001): 3569-3574.

PMID
11739158
Full Text

Benito, AI, Furlong, T, Martin, PJ, Anasetti, C, Appelbaum, FR, Doney, K, Nash, RA, Papayannopoulou, T, Storb, R, Sullivan, KM, Witherspoon, R, and Deeg, HJ. "Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease." Transplantation 72, no. 12 (December 2001): 1924-1929.

PMID
11773890
Full Text

Nishimura, J, Kanakura, Y, Ware, RE, Shichishima, T, Nakakuma, H, Ninomiya, H, DeCastro, CM, Hall, S, Kanamaru, A, Sullivan, KM, Mizoguchi, H, Omine, M, Kinoshita, T, and Rosse, WF. "Flow cytometric analysis in two large cohorts of patients with PNH." BLOOD 98, no. 11 (November 16, 2001): 221A-221A.

Scholars@Duke

Nishimura, J, Kanakura, Y, Ware, RE, Shichishima, T, Nakakuma, H, Ninomiya, H, DeCastro, CM, Hall, S, Kanamaru, A, Sullivan, KM, Mizoguchi, H, Omine, M, Kinoshita, T, and Rosse, WF. "The clinical course of PNH in the USA and in Japan." BLOOD 98, no. 11 (November 16, 2001): 220A-220A.

Scholars@Duke

Walters, MC, Woolfrey, A, Torok-Storb, B, Zaucha, JM, Little, MT, Trachtenberg, E, Sullivan, KM, and Storb, R. "Enrichment of donor erythroid cells after non-myeloablative bone marrow transplantation (BMT) for sickle cell anemia (SCA)." BLOOD 98, no. 11 (November 16, 2001): 490A-490A.

Scholars@Duke

McSweeney, PA, Nash, RA, Sullivan, KM, Crofford, LJ, McDonagh, KT, Dansey, R, Mayes, M, Holmberg, LA, Chen, CS, Rambharose, J, Storek, J, Gooley, TA, LeMaistre, CF, Ryan, K, Sunderhaus, J, and Furst, DE. "High-dose immunosuppressive therapy (HDIT) for severe systemic sclerosis (SSc)." BLOOD 98, no. 11 (November 16, 2001): 395B-395B.

Scholars@Duke

Nash, RA, Bowen, JD, McSweeney, PA, Sullivan, KM, Pavletic, ZS, Maravilla, KR, Al-Omaishi, J, Corboy, JR, Derrington, D, DiPersio, J, Georges, GE, Holmberg, LA, LeMaistre, CF, Openshaw, H, Ryan, K, Sunderhaus, J, Storek, J, Zunt, J, and Kraft, GH. "Treatment of severe multiple sclerosis (MS) with high-dose immunosuppressive therapy (HDIT) and autologous stem cell transplantation (SCT)." BLOOD 98, no. 11 (November 16, 2001): 687A-687A.

Scholars@Duke

Stern, JM, Sullivan, KM, Ott, SM, Seidel, K, Fink, JC, Longton, G, and Sherrard, DJ. "Bone density loss after allogeneic hematopoietic stem cell transplantation: a prospective study." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 7, no. 5 (January 2001): 257-264.

PMID
11400947
Full Text

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