Keith Michael Sullivan, MD

Professor of Medicine
James B. Wyngaarden Professor of Medicine, in the School of Medicine
Member of the Duke Cancer Institute
Campus mail Box 3961 Med Ctr, Durham, NC 27710
Phone (919) 668-1000
Email address sulli025@mc.duke.edu

Research areas

  • Late effects of cancer treatment and stem cell transplantation 
  • Chronic graft-versus-host disease 
  • Transplantation for sickle cell and autoimmune diseases 
  • Knowledge engineering

Overview
Early on, Dr. Sullivan and the team at Fred Hutchinson Cancer Research Center developed a systematic investigative approach for the diagnosis and treatment of chronic graft-versus-host disease (GVHD), the major cause of late morbidity and non-relapse mortality following allogeneic stem cell transplantation (SCT). As a result of this work, it became clear that blood and marrow transplant recipients require systematic long-term follow-up to evaluate and treat late complications of high-dose chemoradiotherapy and SCT.

The program grew into a large multidisciplinary team, resulting in improvement in patient outcome and quality of life. Through the late events project, he also contributed to outcomes research, computer decision support systems, and knowledge engineering for follow-up care. With quality of life as a focus, research pursued the application of SCT to diseases with high morbidity but little immediate mortality. For young patients with advanced, symptomatic sickle cell disease, myeloablative conditioning and SCT from an HLA-identical sibling has led to an 86% long-term survival free of sickle cell disease. For individuals with autoimmune diseases such as multiple sclerosis, scleroderma, and systemic lupus erythematosus, current therapy is often incomplete and significant morbidity from the disease or its treatment is observed.

Recent preclinical and clinical data suggest that high-dose immunosupression and SCT can halt the progression and, in some settings, reverse the course of autoimmune diseases. Since his arrival at Duke University, over 30 centers nationwide are participating in Duke-led phase II and III trials to test the toxicity, efficacy, and quality of life following autologous and allogeneic stem cell transplantation for autoimmune diseases.

These trials will also serve as platforms to study the immune repertoire and mechanistic pathways before and after SCT to gain greater insight into the basic mechanisms of autoimmunity.

A national repository of tissue and cell specimens is also part of these NIH-supported trials to further promote scientific study from these unique patients.

In Their Words

Education and Training

  • M.D., Indiana University at Indianapolis, 1971

Publications

Bruno, B, Gooley, T, Sullivan, KM, Davis, C, Bensinger, WI, Storb, R, and Nash, RA. "Secondary failure of platelet recovery after hematopoietic stem cell transplantation." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 7, no. 3 (January 2001): 154-162.

PMID
11302549
Full Text

Walters, MC, Patience, M, Leisenring, W, Rogers, ZR, Aquino, VM, Buchanan, GR, Roberts, IA, Yeager, AM, Hsu, L, Adamkiewicz, T, Kurtzberg, J, Vichinsky, E, Storer, B, Storb, R, Sullivan, KM, and Multicenter Investigation of Bone Marrow Transplantation for Sickle Cell Disease, . "Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 7, no. 12 (January 2001): 665-673.

PMID
11787529
Full Text

Sullivan, KM, Dykewicz, CA, Longworth, DL, Boeckh, M, Baden, LR, Rubin, RH, Sepkowitz, KA, Centers for Disease Control and Prevention, , Infectious Diseases Society of America, , and American Society for Blood and Marrow Transplantation Practice Guidelines and beyond, . "Preventing opportunistic infections after hematopoietic stem cell transplantation: the Centers for Disease Control and Prevention, Infectious Diseases Society of America, and American Society for Blood and Marrow Transplantation Practice Guidelines and beyond." Hematology Am Soc Hematol Educ Program (2001): 392-421. (Review)

PMID
11722995
Scholars@Duke

Binks, M, Passweg, JR, Furst, D, McSweeney, P, Sullivan, K, Besenthal, C, Finke, J, Peter, HH, Laar, JV, Breedveld, FC, Fibbe, WE, Farge, D, Gluckman, E, Locatelli, F, Martini, A, Hoogen, FVD, Putte, LVD, Schattenberg, AVN, Arnold, R, Bacon, PA, Emery, P, Espigado, I, Hertenstein, B, Hiepe, F, Kashyap, A, Kötter, I, Marmont, A, Martinez, A, Pascual, MJ, Gratwohl, A, Prentice, HG, Black, C, and Tyndall, A. "Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: Procedure related mortality and impact on skin disease." Annals of the Rheumatic Diseases 60, no. 6 (2001): 577-584.

PMID
11350846
Full Text

Naidu, KD, Sullivan, KM, Wang, PP, and Yang, Y. "Managing Personnel through Staff Scheduling Algorithms." Proceedings of the Joint Conference on Information Sciences 5, no. 2 (December 1, 2000): 829-835.

Scholars@Duke

Wang, PP, Sullivan, KM, Naidu, KD, and Yang, Y. "Research on Medical Informatics and Telemedicine." Proceedings of the Joint Conference on Information Sciences 5, no. 2 (December 1, 2000): 827-828.

Scholars@Duke

Yang, Y, Sullivan, KM, Wang, PP, and Naidu, KD. "Applications of Computer Simulation in Medical Scheduling." Proceedings of the Joint Conference on Information Sciences 5, no. 2 (December 1, 2000): 836-841.

Scholars@Duke

McSweeney, PA, Furst, DE, Nash, RA, Holmberg, L, McDonagh, K, Crofford, L, Dansey, R, Mayes, M, Storek, J, Viganego, F, Agee, G, Ryan, K, and Sullivan, KM. "High-dose immunosuppressive therapy (HDIT) and autologous stem cell transplant for severe systemic sclerosis (SSc)." BLOOD 96, no. 11 (November 16, 2000): 844A-844A.

Scholars@Duke

Nash, RA, Dansey, R, Storek, J, Sullivan, KM, Pavletic, S, McDonagh, KT, Kraft, GH, Mayes, MD, Forman, SJ, Holmberg, LA, and McSweeney, PA. "Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after high-dose immunosuppressive therapy (HDIT) and autologous CD34-selected stem cell transplantation (SCT) for severe autoimmune diseases." BLOOD 96, no. 11 (November 16, 2000): 406A-406A.

Scholars@Duke

Nash, RA, Kraft, GH, Bowen, JD, McSweeney, PA, Pavletic, S, Al-Omaishi, J, Corboy, JR, Holmberg, LA, Openshaw, H, Prather, K, Ryan, K, Storek, J, Zunt, JR, and Sullivan, KM. "Treatment of severe multiple sclerosis (MS) with high-dose immunosuppressive therapy (HDIT) and autologous stem cell transplantation (SCT)." BLOOD 96, no. 11 (November 16, 2000): 842A-843A.

Scholars@Duke

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