Kenneth Ward Lyles, MD

Professor of Medicine
Senior Fellow in the Center for the Study of Aging and Human Development
Campus mail Duke Box 3881, Durham, NC 27710
Phone (919) 660-7520
Email address kenneth.lyles@duke.edu

My research activities focus on understanding ways that osteoporotic fractures affect people and trying to learn ways to reduce their impact on affected individuals and prevent further fractures. I have worked with patient with hip and vertebral fractures, gaining insight into the impairments such fractures cause. Also we have learned that a hip fracture is a major risk factor for subsequent fractures after the initial hip fracture. Our group completed a randomized, placebo-controlled trial that we designed with Novartis Pharmaceutical Corporation showing, that an annual infusion of a 5mg of the bisphosphonate zoledronic acid reduced subsequent fractures after a surgical procedure for a hip fracture by 35% when compared to a place infusion (New England Journal of Medicine, 11-1-07). In this study we also observed a 28% reduction in death in the zoledronic acid treated patients. Other research groups have shown that oral bisphosphonates also reduce mortality in patients with osteoporosis. Currently, we, with a number of collaborators, are conducting both animal and human studies to better understand this beneficial effect upon mortality.

In other work, our group tries to understand how other diseases such as strokes and spinal cord injury, and medications such as anticonvulsants place patients at risk for fractures. As we understand the epidemiology of these types of fractures, we plan to develop intervention trials to test whether we can reduce the occurrence of these fractures.

In addition to the above described work our group has help design and conduct a number of phase 1,2 and 3 clinical trials in Paget's disease of Bone and osteoporosis.

KEY WORDS:
Oteoporosis
Hip and vertebra fractures
Paget's disease of bone
Mobility impairments from metabolic bone diseases
Bisphosphonates

Education and Training

  • M.D., Virginia Commonwealth University, 1974

Publications

Lyles, KW, and Colon-Emeric, CS. "Does Low Bone Mineral Density Cause a Broken Heart?." JACC: Heart Failure 2, no. 4 (January 1, 2014): 390-391.

Full Text

White, HK, Buhr, G, McConnell, E, Sullivan, RJ, Twersky, J, Colon-Emeric, C, Heflin, M, Cutson, TM, Logan, W, Lyles, K, and Pinheiro, SO. "An advanced course in long term care for geriatric medicine fellows." J Am Med Dir Assoc 14, no. 7 (July 2013): 499-506.

PMID
23623522
Full Text

Wolfe, F, Bolster, MB, O'Connor, CM, Michaud, K, Lyles, KW, and Colón-Emeric, CS. "Bisphosphonate use is associated with reduced risk of myocardial infarction in patients with rheumatoid arthritis." J Bone Miner Res 28, no. 5 (May 2013): 984-991.

PMID
23074131
Full Text

Reid, IR, Black, DM, Eastell, R, Bucci-Rechtweg, C, Su, G, Hue, TF, Mesenbrink, P, Lyles, KW, Boonen, S, and HORIZON Pivotal Fracture Trial and HORIZON Recurrent Fracture Trial Steering Committees, . "Reduction in the risk of clinical fractures after a single dose of zoledronic Acid 5 milligrams." The Journal of Clinical Endocrinology and Metabolism 98, no. 2 (February 2013): 557-563.

PMID
23293335
Full Text

Prieto-Alhambra, D, Judge, A, Arden, NK, Cooper, C, Lyles, KW, and Javaid, MK. "Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial." Osteoporosis International (2013): 1-7.

PMID
23812596
Full Text

White, HK, Buhr, G, McConnell, E, Sullivan, RJ, Twersky, J, Colon-Emeric, C, Heflin, M, Cutson, TM, Logan, W, Lyles, K, and Pinheiro, SO. "An Advanced Course in Long Term Care for Geriatric Medicine Fellows." Journal of the American Medical Directors Association 14, no. 7 (2013): 499-506.

Full Text

Boonen, S, Eastell, R, Su, G, Mesenbrink, P, Cosman, F, Cauley, JA, Reid, IR, Claessens, F, Vanderschueren, D, Lyles, KW, and Black, DM. "Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 27, no. 7 (July 2012): 1487-1493.

PMID
22431413
Full Text

Colón-Emeric, CS, and Lyles, KW. "How much vitamin D should I take?." The Journal of Clinical Investigation 122, no. 5 (May 2012): 1598-1599.

PMID
22690399
Full Text

Adachi, JD, Lyles, K, Boonen, S, Colón-Emeric, C, Hyldstrup, L, Nordsletten, L, Pieper, C, Recknor, C, Su, G, Bucci-Rechtweg, C, and Magaziner, J. "Subtrochanteric fractures in bisphosphonate-naive patients: results from the HORIZON-recurrent fracture trial." Calcified Tissue International 89, no. 6 (December 2011): 427-433.

PMID
22038744
Full Text

Boonen, S, Orwoll, E, Magaziner, J, Colón-Emeric, CS, Adachi, JD, Bucci-Rechtweg, C, Haentjens, P, Kaufman, J-M, Rizzoli, R, Vanderschueren, D, Claessens, F, Sermon, A, Witvrouw, R, Milisen, K, Su, G, Lyles, KW, and HORIZON Recurrent Fracture Trial, . "Once-yearly zoledronic acid in older men compared with women with recent hip fracture." J Am Geriatr Soc 59, no. 11 (November 2011): 2084-2090.

PMID
22091563
Full Text

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